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The advent of quantum computing processors with possibility to scale beyond experimental capacities magnifies the importance of studying their applications. Combinatorial optimization problems can be one of the promising applications of…

Quantum Physics · Physics 2017-08-18 Ehsan Zahedinejad , Arman Zaribafiyan

Molecular conformation generation (MCG) is a fundamental and important problem in drug discovery. Many traditional methods have been developed to solve the MCG problem, such as systematic searching, model-building, random searching,…

Computational Engineering, Finance, and Science · Computer Science 2023-03-28 Gengmo Zhou , Zhifeng Gao , Zhewei Wei , Hang Zheng , Guolin Ke

Quantitative chemistry is central to modern chemical research, yet the ability of large language models (LLMs) to perform its rigorous, step-by-step calculations remains underexplored. To fill this blank, we propose QCBench, a Quantitative…

Artificial Intelligence · Computer Science 2025-11-05 Jiaqing Xie , Weida Wang , Ben Gao , Zhuo Yang , Haiyuan Wan , Shufei Zhang , Tianfan Fu , Yuqiang Li

We give a quantum algorithm for solving the Bounded Distance Decoding (BDD) problem with a subexponential approximation factor on a class of integer lattices. The quantum algorithm uses a well-known but challenging-to-use quantum state on…

Quantum Physics · Physics 2022-02-01 Lior Eldar , Sean Hallgren

Finding the ground-state energy of molecules is an important and challenging computational problem for which quantum computing can potentially find efficient solutions. The variational quantum eigensolver (VQE) is a quantum algorithm that…

Quantum Physics · Physics 2023-02-15 Daniel Yoffe , Amir Natan , Adi Makmal

We numerically analyze the possibility of turning off post-smoothing (relaxation) in geometric multigrid when used as a preconditioner in conjugate gradient linear and eigenvalue solvers for the 3D Laplacian. The geometric Semicoarsening…

Numerical Analysis · Computer Science 2015-06-09 Henricus Bouwmeester , Andrew Dougherty , Andrew V. Knyazev

We develop an optimal control algorithm for robust quantum gate preparation in open environments with the state of the quantum system represented using the Lindblad master equation. The algorithm is based on adaptive linearization and…

Optimization and Control · Mathematics 2025-03-17 Luke S. Baker , Syed A. Shah , Anatoly Zlotnik , Andrei Piryatinski

We introduce a novel class of localized atomic environment representations, based upon the Coulomb matrix. By combining these functions with the Gaussian approximation potential approach, we present LC-GAP, a new system for generating…

Machine Learning · Statistics 2016-12-07 James Barker , Johannes Bulin , Jan Hamaekers , Sonja Mathias

Standard Bayesian Optimization (BO) assumes uniform smoothness across the search space an assumption violated in multi-regime problems such as molecular conformation search through distinct energy basins or drug discovery across…

Machine Learning · Computer Science 2026-01-29 Yan Zhang , Xuefeng Liu , Sipeng Chen , Sascha Ranftl , Chong Liu , Shibo Li

Variational quantum algorithms rely on the optimization of parameterized quantum circuits in noisy settings. The commonly used back-propagation procedure in classical machine learning is not directly applicable in this setting due to the…

Quantum Physics · Physics 2024-08-27 Zhiyan Ding , Taehee Ko , Jiahao Yao , Lin Lin , Xiantao Li

In recent years, quantum computing has drawn significant interest within the field of high-energy physics. We explore the potential of quantum algorithms to resolve the combinatorial problems in particle physics experiments. As a concrete…

High Energy Physics - Phenomenology · Physics 2024-11-12 Jacob L. Scott , Zhongtian Dong , Taejoon Kim , Kyoungchul Kong , Myeonghun Park

Consider the problem of minimizing an expected logarithmic loss over either the probability simplex or the set of quantum density matrices. This problem includes tasks such as solving the Poisson inverse problem, computing the…

Optimization and Control · Mathematics 2024-03-12 Chung-En Tsai , Hao-Chung Cheng , Yen-Huan Li

Variational quantum eigensolver (VQE) is demonstrated to be the promising methodology for quantum chemistry based on near-term quantum devices. However, many problems are yet to be investigated for this methodology, such as the influences…

Chemical Physics · Physics 2021-01-18 Xian-Hu Zha , Chao Zhang , Dengdong Fan , Pengxiang Xu , Shiyu Du , Rui-Qin Zhang , Chen Fu

We present an efficient approach to simulate real-time quantum dynamics using Projected Variational Quantum Dynamics (PVQD), where the computational cost is reduced by strategically optimizing only a subset of the variational parameters at…

Quantum Physics · Physics 2026-01-06 Harshdeep Singh , Sonjoy Majumder , Sabyashachi Mishra

We study first-order methods with preconditioning for solving structured nonlinear convex optimization problems. We propose a new family of preconditioners generated by symmetric polynomials. They provide first-order optimization methods…

Optimization and Control · Mathematics 2023-01-31 Nikita Doikov , Anton Rodomanov

Convex quadratic programming (QP) is an essential class of optimization problems with broad applications across various fields. Traditional QP solvers, typically based on simplex or barrier methods, face significant scalability challenges.…

Optimization and Control · Mathematics 2024-10-08 Yicheng Huang , Wanyu Zhang , Hongpei Li , Dongdong Ge , Huikang Liu , Yinyu Ye

Discrete Laplacian operators arise ubiquitously in scientific computing and frequently appear in quantum algorithms for tasks such as linear algebra, Hamiltonian simulation, and partial differential equations. Block encoding provides the…

Quantum Physics · Physics 2026-04-30 Alexandre Boutot , Viraj Dsouza

Preconditioning is at the core of modern many-fermion Monte Carlo algorithms, such as Hybrid Monte Carlo, where the repeated solution of a linear problem involving an ill-conditioned matrix is needed. We report on a performance comparison…

High Energy Physics - Lattice · Physics 2010-08-24 Timour Ten , Joaquín E. Drut , Timo A. Lähde

Linear programming (LP) is an extremely useful tool and has been successfully applied to solve various problems in a wide range of areas, including operations research, engineering, economics, or even more abstract mathematical areas such…

Data Structures and Algorithms · Computer Science 2020-03-19 Agniva Chowdhury , Palma London , Haim Avron , Petros Drineas

The variational quantum eigensolver (or VQE) uses the variational principle to compute the ground state energy of a Hamiltonian, a problem that is central to quantum chemistry and condensed matter physics. Conventional computing methods are…