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Large language models (LLMs) have attracted significant attention for potential applications in digital health, while their application in mental health is subject to ongoing debate. This systematic review aims to evaluate the usage of LLMs…

Computers and Society · Computer Science 2024-08-14 Zhijun Guo , Alvina Lai , Johan Hilge Thygesen , Joseph Farrington , Thomas Keen , Kezhi Li

Large language models (LLMs) have rapidly advanced natural language processing, driving significant breakthroughs in tasks such as text generation, machine translation, and domain-specific reasoning. The field now faces a critical dilemma…

Computation and Language · Computer Science 2025-10-15 Jiya Manchanda , Laura Boettcher , Matheus Westphalen , Jasser Jasser

This paper investigates integrating large language models (LLMs) with advanced hardware, focusing on developing a general-purpose device designed for enhanced interaction with LLMs. Initially, we analyze the current landscape, where virtual…

Hardware Architecture · Computer Science 2024-08-21 Jiajun Xu , Qun Wang , Yuhang Cao , Baitao Zeng , Sicheng Liu

While modern dialogue systems heavily rely on large language models (LLMs), their implementation often goes beyond pure LLM interaction. Developers integrate multiple LLMs, external tools, and databases. Therefore, assessment of the…

Artificial Intelligence · Computer Science 2025-07-23 Roman Mayr , Michel Schimpf , Thomas Bohné

As large language models (LLMs) become increasingly prevalent, understanding human-LLM interactions is emerging as a central priority in psychological research. Online experiments offer an efficient means to study human-LLM interactions,…

Human-Computer Interaction · Computer Science 2025-11-27 R. Bermudez Schettino , A. Dasmeh , L. Brinkmann

The rapid advancements in large language models (LLMs) have opened up new opportunities for transforming patient engagement in healthcare through conversational AI. This paper presents an overview of the current landscape of LLMs in…

Artificial Intelligence · Computer Science 2024-11-27 Bo Wen , Raquel Norel , Julia Liu , Thaddeus Stappenbeck , Farhana Zulkernine , Huamin Chen

The past decade has been transformative for mental health research and practice. The ability to harness large repositories of data, whether from electronic health records (EHR), mobile devices, or social media, has revealed a potential for…

Computation and Language · Computer Science 2023-11-28 Munmun De Choudhury , Sachin R. Pendse , Neha Kumar

In this paper, we propose a novel system that integrates state-of-the-art, domain-specific large language models with advanced information retrieval techniques to deliver comprehensive and context-aware responses. Our approach facilitates…

Recent developments in large language models (LLMs) have unlocked new opportunities for healthcare, from information synthesis to clinical decision support. These new LLMs are not just capable of modeling language, but can also act as…

Human-Computer Interaction · Computer Science 2023-09-21 Nikita Mehandru , Brenda Y. Miao , Eduardo Rodriguez Almaraz , Madhumita Sushil , Atul J. Butte , Ahmed Alaa

With the introduction of ChatGPT, Large Language Models (LLMs) have received enormous attention in healthcare. Despite their potential benefits, researchers have underscored various ethical implications. While individual instances have…

Computers and Society · Computer Science 2024-07-09 Joschka Haltaufderheide , Robert Ranisch

The year 2023 marked a significant surge in the exploration of applying large language model (LLM) chatbots, notably ChatGPT, across various disciplines. We surveyed the applications of ChatGPT in bioinformatics and biomedical informatics…

Other Quantitative Biology · Quantitative Biology 2024-06-13 Jinge Wang , Zien Cheng , Qiuming Yao , Li Liu , Dong Xu , Gangqing Hu

Large Language Models (LLMs) have gained significant attention in the medical domain for their human-level capabilities, leading to increased efforts to explore their potential in various healthcare applications. However, despite such a…

Artificial Intelligence · Computer Science 2024-10-25 Yifan Yang , Qiao Jin , Qingqing Zhu , Zhizheng Wang , Francisco Erramuspe Álvarez , Nicholas Wan , Benjamin Hou , Zhiyong Lu

Large Language Models (LLMs) have quickly risen to prominence due to their ability to perform at or close to the state-of-the-art in a variety of fields while handling natural language. An important field of research is the application of…

Cryptography and Security · Computer Science 2024-02-28 Gabriel de Jesus Coelho da Silva , Carlos Becker Westphall

We present BioLunar, developed using the Lunar framework, as a tool for supporting biological analyses, with a particular emphasis on molecular-level evidence enrichment for biomarker discovery in oncology. The platform integrates Large…

Large language models have gained widespread popularity for their ability to process natural language inputs and generate insights derived from their training data, nearing the qualities of true artificial intelligence. This advancement has…

Software Engineering · Computer Science 2024-11-25 Narcisa Guran , Florian Knauf , Man Ngo , Stefan Petrescu , Jan S. Rellermeyer

The development of Large Language Models (LLMs) has led to significant advancements in natural language processing and enabled numerous applications across various industries. However, many LLM-based solutions operate as open systems…

Cryptography and Security · Computer Science 2025-03-05 Marian Lambert , Thomas Schuster , Nico Döring , Robin Krüger

Large language models (LLMs) are rapidly transforming materials science. This review examines recent LLM applications across the materials discovery pipeline, focusing on three key areas: mining scientific literature , predictive modelling,…

Computation and Language · Computer Science 2025-11-17 Fengxu Yang , Weitong Chen , Jack D. Evans

The ever-growing corpus of scientific literature presents significant challenges for researchers with respect to discovery, management, and annotation of relevant publications. Traditional platforms like Semantic Scholar, BibSonomy, and…

Information Retrieval · Computer Science 2024-01-18 Tom Völker , Jan Pfister , Tobias Koopmann , Andreas Hotho

This research addresses the challenges inherent in developing Artificial Intelligence (AI) applications, particularly those leveraging Large Language Models (LLMs). While AI vendors provide Application Programming Interfaces (APIs) and…

Artificial Intelligence · Computer Science 2026-05-20 Chun-Hsiung Tseng , Hao-Chiang Koong Lin , Andrew Chih-Wei Huang , Yung-Hui Chen , Jia-Rou Lin