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Electronic Health Records (EHRs) have been increasingly used as real-world evidence (RWE) to support the discovery and validation of new drug indications. This paper surveys current approaches to EHR-based drug repurposing, covering data…

Applications · Statistics 2025-11-21 Nabasmita Talukdar , Xiaodan Zhang , Shreya Paithankar , Hui Wang , Bin Chen

Objective: Medical relations are the core components of medical knowledge graphs that are needed for healthcare artificial intelligence. However, the requirement of expert annotation by conventional algorithm development processes creates a…

Machine Learning · Computer Science 2020-09-09 Yucong Lin , Keming Lu , Yulin Chen , Chuan Hong , Sheng Yu

Unstructured data in Electronic Health Records (EHRs) often contains critical information -- complementary to imaging -- that could inform radiologists' diagnoses. But the large volume of notes often associated with patients together with…

Computation and Language · Computer Science 2024-06-12 Hiba Ahsan , Denis Jered McInerney , Jisoo Kim , Christopher Potter , Geoffrey Young , Silvio Amir , Byron C. Wallace

Electronic health record (EHR) systems present clinicians with vast repositories of clinical information, creating a significant cognitive burden where critical details are easily overlooked. While Large Language Models (LLMs) offer…

Computation and Language · Computer Science 2026-03-17 Samuel Thio , Matthew Lewis , Spiros Denaxas , Richard JB Dobson

Electronic Medical Records (EMRs), while integral to modern healthcare, present challenges for clinical reasoning and diagnosis due to their complexity and information redundancy. To address this, we proposed medIKAL (Integrating Knowledge…

Computation and Language · Computer Science 2025-02-18 Mingyi Jia , Junwen Duan , Yan Song , Jianxin Wang

Clinical Reasoning on Electronic Health Records (EHRs) is a fundamental yet challenging task in modern healthcare. While in-context learning (ICL) offers a promising inference-time adaptation paradigm for large language models (LLMs) in EHR…

Machine Learning · Computer Science 2026-04-09 Yue Fang , Weibin Liao , Yuxin Guo , Jiaran Gao , Hongxin Ding , Jinyang Zhang , Xinke Jiang , Zhibang Yang , Junfeng Zhao , Yasha Wang , Liantao Ma

Electronic Health Records (EHRs) provide rich longitudinal clinical evidence that is central to medical decision-making, motivating the use of retrieval-augmented generation (RAG) to ground large language model (LLM) predictions. However,…

Artificial Intelligence · Computer Science 2026-01-30 Lang Cao , Qingyu Chen , Yue Guo

Question Answering (QA) is a widely-used framework for developing and evaluating an intelligent machine. In this light, QA on Electronic Health Records (EHR), namely EHR QA, can work as a crucial milestone towards developing an intelligent…

Databases · Computer Science 2021-08-03 Junwoo Park , Youngwoo Cho , Haneol Lee , Jaegul Choo , Edward Choi

Despite the large number of patients in Electronic Health Records (EHRs), the subset of usable data for modeling outcomes of specific phenotypes are often imbalanced and of modest size. This can be attributed to the uneven coverage of…

Machine Learning · Computer Science 2021-03-25 Mohamed Ghalwash , Zijun Yao , Prithwish Chakraborty , James Codella , Daby Sow

Due to the increasing adoption of electronic health records (EHR), large scale EHRs have become another rich data source for translational clinical research. Despite its potential, deriving generalizable knowledge from EHR data remains…

Machine Learning · Statistics 2023-06-01 Junwei Lu , Jin Yin , Tianxi Cai

Machine learning in healthcare requires effective representation of structured medical codes, but current methods face a trade off: knowledge graph based approaches capture formal relationships but miss real world patterns, while data…

Machine Learning · Computer Science 2025-10-07 Ahmed Elhussein , Paul Meddeb , Abigail Newbury , Jeanne Mirone , Martin Stoll , Gamze Gursoy

Electronic Health Records (EHR) are crucial for the success of digital healthcare, with a focus on putting consumers at the center of this transformation. However, the digitalization of healthcare records brings along security and privacy…

Machine Learning · Computer Science 2024-10-07 Vinaytosh Mishra , Kishu Gupta , Deepika Saxena , Ashutosh Kumar Singh

The growing adoption of electronic health record (EHR) systems has provided unprecedented opportunities for predictive modeling to guide clinical decision making. Structured EHRs contain longitudinal observations of patients across hospital…

Machine Learning · Computer Science 2026-03-12 Deyi Li , Zijun Yao , Qi Xu , Muxuan Liang , Lingyao Li , Zijian Xu , Mei Liu

Digital healthcare systems have enabled the collection of mass healthcare data in electronic healthcare records (EHRs), allowing artificial intelligence solutions for various healthcare prediction tasks. However, existing studies often…

Machine Learning · Computer Science 2025-08-27 Zi Cai , Yu Liu , Zhiyao Luo , Tingting Zhu

Electronic Health Records (EHRs) contain a large volume of heterogeneous patient data, which are useful at the point of care and for retrospective research. These data are typically stored in relational databases. Gaining an integrated view…

Computers and Society · Computer Science 2018-06-04 Dina Levy-Lambert , Jen J. Gong , Tristan Naumann , Tom J. Pollard , John V. Guttag

The development and adoption of Electronic Health Records (EHR) and health monitoring Internet of Things (IoT) Devices have enabled digitization of patient records and has also substantially transformed the healthcare delivery system in…

Human-Computer Interaction · Computer Science 2021-10-20 Manan Shukla , Jianjing Lin , Oshani Seneviratne

An Electronic Health Record (EHR) system must enable efficient availability of meaningful, accurate and complete data to assist improved clinical administration through the development, implementation and optimisation of clinical pathways.…

Computers and Society · Computer Science 2018-02-05 P. Vimalachandran , H. Wang , Y. Zhang , B. Heyward , F. Whittaker

The rapid adoption of Electronic Health Records (EHRs) has been instrumental in streamlining administrative tasks, increasing transparency, and enabling continuity of care across providers. An unintended consequence of the increased…

Computation and Language · Computer Science 2024-04-02 Griffin Adams

In studies that rely on data from electronic health records (EHRs), unstructured text data such as clinical progress notes offer a rich source of information about patient characteristics and care that may be missing from structured data.…

Computation and Language · Computer Science 2024-05-22 Reagan Mozer , Aaron R. Kaufman , Leo A. Celi , Luke Miratrix
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