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We report, to our knowledge, the first end-to-end application of Generative Adversarial Networks (GANs) towards the synthesis of Optical Coherence Tomography (OCT) images of the retina. Generative models have gained recent attention for the…

Computer Vision and Pattern Recognition · Computer Science 2019-02-19 Stephen G. Odaibo , M. D. , M. S. , M. S.

Limited-Angle Computed Tomography (LACT) is a challenging inverse problem where missing angular projections lead to incomplete sinograms and severe artifacts in the reconstructed images. While recent learning-based methods have demonstrated…

Image and Video Processing · Electrical Eng. & Systems 2025-07-09 Jiaqi Guo , Santiago López-Tapia

Robotic laser systems offer the potential for sub-millimeter, non-contact, high-precision tissue resection, yet existing platforms lack volumetric planning and intraoperative feedback. We present RATS (Robot-Assisted Tissue Surgery), an…

In medical imaging, there are clinically relevant segmentation tasks where the output mask is a projection to a subset of input image dimensions. In this work, we propose a novel convolutional neural network architecture that can…

Image and Video Processing · Electrical Eng. & Systems 2021-08-03 Dmitrii Lachinov , Philipp Seeboeck , Julia Mai , Ursula Schmidt-Erfurth , Hrvoje Bogunovic

Modern biomedical image analysis using deep learning often encounters the challenge of limited annotated data. To overcome this issue, deep generative models can be employed to synthesize realistic biomedical images. In this regard, we…

Image and Video Processing · Electrical Eng. & Systems 2026-02-23 Yuli Wu , Weidong He , Dennis Eschweiler , Ningxin Dou , Zixin Fan , Shengli Mi , Peter Walter , Johannes Stegmaier

Recent advances in representation learning often rely on holistic embeddings that entangle multiple semantic components, limiting interpretability and generalization. These issues are especially critical in medical imaging, where downstream…

Computer Vision and Pattern Recognition · Computer Science 2025-11-21 Sifan Song , Siyeop Yoon , Pengfei Jin , Sekeun Kim , Matthew Tivnan , Yujin Oh , Runqi Meng , Ling Chen , Zhiliang Lyu , Dufan Wu , Ning Guo , Xiang Li , Quanzheng Li

Large-volume optical coherence tomography (OCT)-setups employ scanning mirrors and suffer from non-linear geometric distortion artifacts in which the degree of distortion is determined by the maximum angles over which the mirrors rotate. In…

Optical diffraction tomography (ODT) provides three-dimensional refractive index (RI) tomograms of a transparent microscopic object. However, because of the finite numerical aperture of objective lenses, ODT has the limited access to…

Optics · Physics 2017-11-22 Moosung Lee , Seungwoo Shin , YongKeun Park

High Dynamic Range (HDR) imaging via multi-exposure fusion is an important task for most modern imaging platforms. In spite of recent developments in both hardware and algorithm innovations, challenges remain over content association…

Image and Video Processing · Electrical Eng. & Systems 2022-04-13 Jie Chen , Zaifeng Yang , Tsz Nam Chan , Hui Li , Junhui Hou , Lap-Pui Chau

Optical Coherence Tomography (OCT) provides high-resolution, 3D, and non-invasive visualization of retinal layers in vivo, serving as a critical tool for lesion localization and disease diagnosis. However, its widespread adoption is limited…

Optical Coherence Tomography (OCT) is a non-invasive imaging modality essential for diagnosing various eye diseases. Despite its clinical significance, developing OCT-based diagnostic tools faces challenges, such as limited public datasets,…

Computer Vision and Pattern Recognition · Computer Science 2025-01-30 Mohammadreza Saraei , Igor Kozak , Eung-Joo Lee

Optical coherence tomography (OCT) is a noninvasive imaging modality which can be used to obtain depth images of the retina. The changing layer thicknesses can thus be quantified by analyzing these OCT images, moreover these changes have…

Computer Vision and Pattern Recognition · Computer Science 2018-03-15 Yufan He , Aaron Carass , Bruno M. Jedynak , Sharon D. Solomon , Shiv Saidha , Peter A. Calabresi , Jerry L. Prince

In this chapter a general mathematical model of Optical Coherence Tomography (OCT) is presented on the basis of the electromagnetic theory. OCT produces high resolution images of the inner structure of biological tissues. Images are…

Numerical Analysis · Mathematics 2016-04-19 Peter Elbau , Leonidas Mindrinos , Otmar Scherzer

Geographic atrophy (GA) is a key biomarker of dry age-related macular degeneration (AMD) traditionally identified through color fundus photography. Hyper-transmission defects (hyperTDs), a feature highly correlated with GA, have recently…

Quantitative Methods · Quantitative Biology 2025-11-04 Yukun Guo , An-Lun Wu , Tristan T. Hormel , Liqin Gao , Min Gao , Thomas S. Hwang , Steven T. Bailey , Yali Jia

Optical Coherence Tomography (OCT) imaging is pivotal in diagnosing ophthalmic conditions by providing detailed cross-sectional images of the anterior and posterior segments of the eye. Nonetheless, speckle noise and other imaging artifacts…

Image and Video Processing · Electrical Eng. & Systems 2024-09-26 Akkidas Noel Prakash , Jahnvi Sai Ganta , Ramaswami Krishnadas , Tin A. Tunc , Satish K Panda

Optical coherence tomography angiography (OCTA) is an important imaging modality in many bioengineering tasks. The image quality of OCTA, however, is often degraded by Bulk Motion Artifacts (BMA), which are due to micromotion of subjects…

Computer Vision and Pattern Recognition · Computer Science 2022-03-29 Jiaxiang Ren , Kicheon Park , Yingtian Pan , Haibin Ling

Allying high-resolution with a large field-of-view (FOV) is of great importance in the fields of biology and medicine, but particularly challenging when imaging non-flat living samples such as the human retina. Indeed, high-resolution is…

This paper proposes a novel Attention-based Multi-Reference Super-resolution network (AMRSR) that, given a low-resolution image, learns to adaptively transfer the most similar texture from multiple reference images to the super-resolution…

Computer Vision and Pattern Recognition · Computer Science 2021-09-01 Marco Pesavento , Marco Volino , Adrian Hilton

Reference-based image super-resolution (RefSR) is a promising SR branch and has shown great potential in overcoming the limitations of single image super-resolution. While previous state-of-the-art RefSR methods mainly focus on improving…

Computer Vision and Pattern Recognition · Computer Science 2022-11-09 Lin Zhang , Xin Li , Dongliang He , Fu Li , Yili Wang , Zhaoxiang Zhang

We propose a novel method for non-rigid 3-D motion correction of orthogonally raster-scanned optical coherence tomography angiography volumes. This is the first approach that aligns predominantly axial structural features like retinal…

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