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Since anatomic MRI is presently not able to directly discern neuronal loss in Parkinson's Disease (PD), studying the associated functional connectivity (FC) changes seems a promising approach toward developing non-invasive and…

Neurons and Cognition · Quantitative Biology 2018-02-07 Liviu Badea , Mihaela Onu , Tao Wu , Adina Roceanu , Ovidiu Bajenaru

Background: The treatment of depressive episodes is well established, with clearly demonstrated effectiveness of antidepressants and psychotherapies. However, more than one-third of depressed patients do not respond to treatment.…

Neurons and Cognition · Quantitative Biology 2024-03-29 Sébastien Dam , Jean-Marie Batail , Gabriel H Robert , Dominique Drapier , Pierre Maurel , Julie Coloigner

Functional connectivity, as estimated using resting state fMRI, has shown potential in bridging the gap between pathophysiology and cognition. However, clinical use of functional connectivity biomarkers is impeded by unreliable estimates of…

This paper studies change-points in human brain functional connectivity (FC) and seeks patterns that are common across multiple subjects under identical external stimulus. FC relates to the similarity of fMRI responses across different…

Neurons and Cognition · Quantitative Biology 2020-03-05 Mengyu Dai , Zhengwu Zhang , Anuj Srivastava

{Introduction: } Dementia is a neurological disorder associated with aging that can cause a loss of cognitive functions, impacting daily life. Alzheimer's disease (AD) is the most common cause of dementia, accounting for 50--70\% of cases,…

Neurons and Cognition · Quantitative Biology 2023-11-07 Zaineb Ajra , Binbin Xu , Gérard Dray , Jacky Montmain , Stéphane Perrey

Recently, there has been a growing interest in monitoring brain activity for individual recognition system. So far these works are mainly focussing on single channel data or fragment data collected by some advanced brain monitoring…

Computer Vision and Pattern Recognition · Computer Science 2018-01-18 Lei Chu , Robert Qiu , Haichun Liu , Zenan Ling , Tianhong Zhang , Jijun Wang

Several brain foundation models (FM) have recently been proposed to predict brain disorders by modelling dynamic functional connectivity (FC). While they demonstrate remarkable model performance and zero- or few-shot generalization, the…

Neurons and Cognition · Quantitative Biology 2026-04-27 Deepank Girish , Yi Hao Chan , Sukrit Gupta , Jing Xia , Jagath C. Rajapakse

Most generally, dynamic functional connectivity (FC) refers to the non-instantaneous couplings across timeseries from a set of brain areas, here as measured by fMRI. This is in contrast to static FC, which is defined as purely instantaneous…

Neurons and Cognition · Quantitative Biology 2023-01-10 Christine Ahrends , Diego Vidaurre

Functional connectivity is a fundamental property of neural networks that quantifies the segregation and integration of information between cortical areas. Due to mathematical complexity, a theory that could explain how the parameters of…

Neurons and Cognition · Quantitative Biology 2016-05-27 Diego Fasoli , Anna Cattani , Stefano Panzeri

Functional Magnetic Resonance Imaging (fMRI) is commonly utilized to study human brain activity, including abnormal functional properties related to neurodegenerative diseases. This study aims to investigate the differences in the…

Neurons and Cognition · Quantitative Biology 2023-05-17 Yongcheng Yao

Functional connectivity (FC) between brain regions tracks symptom severity in many neuropsychiatric disorders. Transcranial magnetic stimulation (TMS) directly alters regional activity and indirectly alters FC. Predicting how FC will change…

Neurons and Cognition · Quantitative Biology 2022-08-25 Andrew C. Murphy , Romain Duprat , Theodore D. Satterthwaite , Desmond J. Oathes , Dani S. Bassett

Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder whose neuroimaging-based diagnosis remains challenging due to complex time-varying disruptions in brain connectivity. Functional MRI (fMRI) provides…

Machine Learning · Computer Science 2026-03-30 Qurat Ul Ain , Alptekin Temizel , Soyiba Jawed

Deep reinforcement learning (DRL) algorithms have the potential to provide new insights into psychiatric disorders. Here we create a DRL model of schizophrenia: a complex psychotic disorder characterized by anhedonia, avoidance, temporal…

Neurons and Cognition · Quantitative Biology 2025-10-30 Xena Al-Hejji , Santina Duarte , Jose Guillermo Gomez Castro , Edgar Bermudez Contreras , Eric Chalmers

Background: Non-linear alterations in brain network connectivity may represent early neural signatures of Alzheimer's disease (AD) pathology in cognitively normal older adults. Understanding these changes and their cognitive relevance may…

Neurons and Cognition · Quantitative Biology 2026-04-22 Junjie Wu , Benjamin B Risk , Taylor A James , Nicholas Seyfried , David W Loring , Felicia C Goldstein , Allan I Levey , James J Lah , Deqiang Qiu

Neuropsychiatric disorders, such as Alzheimer's disease (AD), depression, and autism spectrum disorder (ASD), are characterized by linguistic and acoustic abnormalities, offering potential biomarkers for early detection. Despite the promise…

Computation and Language · Computer Science 2025-12-25 Zhongren Dong , Haotian Guo , Weixiang Xu , Huan Zhao , Zixing Zhang

Anatomical and functional brain studies have converged to the hypothesis that Autism Spectrum Disorders (ASD) are associated with atypical connectivity. Using a modified resting-state paradigm to drive subjects' attention, we provide…

Neurons and Cognition · Quantitative Biology 2012-11-21 Pablo Barttfeld , Bruno Wicker , Sebastián Cukier , Silvana Navarta , Sergio Lew , Ramón Leiguarda , Mariano Sigman

Electroencephalography (EEG)-based attention disorder research seeks to understand brain activity patterns associated with attention. Previous studies have mainly focused on identifying brain regions involved in cognitive processes or…

Neurons and Cognition · Quantitative Biology 2024-10-15 Debashis Das Chakladar , Foteini Simistira Liwicki , Rajkumar Saini

We conduct an imaging genetics study to explore how effective brain connectivity in the default mode network (DMN) may be related to genetics within the context of Alzheimer's disease and mild cognitive impairment. We develop an analysis of…

Neurons and Cognition · Quantitative Biology 2020-06-03 Yunlong Nie , Eugene Opoku , Laila Yasmin , Yin Song , Jie Wang , Sidi Wu , Vanessa Scarapicchia , Jodie Gawryluk , Liangliang Wang , Jiguo Cao , Farouk S. Nathoo

Autism Spectrum Disorder(ASD) is a set of neurodevelopmental conditions that affect patients' social abilities. In recent years, many studies have employed deep learning to diagnose this brain dysfunction through functional MRI (fMRI).…

Image and Video Processing · Electrical Eng. & Systems 2021-10-26 Li Pan , Jundong Liu , Mingqin Shi , Chi Wah Wong , Kei Hang Katie Chan

By focusing on melancholic features with biological homogeneity, this study aimed to identify a small number of critical functional connections (FCs) that were specific only to the melancholic type of MDD. On the resting-state fMRI data,…

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