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Standard fMRI connectivity analyses depend on aggregating the time series of individual voxels within regions of interest (ROIs). In certain cases, this spatial aggregation implies a loss of valuable functional and anatomical information…

Neurons and Cognition · Quantitative Biology 2019-08-12 Ruben Sanchez-Romero , Joseph D. Ramsey , Kun Zhang , Clark Glymour

Functional connectivity (FC) analysis of resting-state fMRI data provides a framework for characterizing brain networks and their association with participant-level covariates. Due to the high dimensionality of neuroimaging data, standard…

Methodology · Statistics 2025-08-18 Wei Zhao , Brian J. Reich , Emily C. Hector

The functional network approach, where fMRI BOLD time series are mapped to networks depicting functional relationships between brain areas, has opened new insights into the function of the human brain. In this approach, the choice of…

Neurons and Cognition · Quantitative Biology 2017-11-10 Onerva Korhonen , Heini Saarimäki , Enrico Glerean , Mikko Sams , Jari Saramäki

Large efforts are currently under way to systematically map functional connectivity between all pairs of millimeter-scale brain regions using big volumes of neuroimaging data. Functional magnetic resonance imaging (fMRI) can produce these…

Neurons and Cognition · Quantitative Biology 2014-09-24 Enzo Tagliazucchi , Helmut Laufs , Dante R. Chialvo

Resting-state brain functional connectivity quantifies the synchrony between activity patterns of different brain regions. In functional magnetic resonance imaging (fMRI), each region comprises a set of spatially contiguous voxels at which…

Methodology · Statistics 2025-11-07 Ruobin Liu , Chao Zhang , Chau Tran , Sophie Achard , Wendy Meiring , Alexander Petersen

Functional Magnetic Resonance Imaging (fMRI) is a primary modality for studying brain activity. Modeling spatial dependence of imaging data at different scales is one of the main challenges of contemporary neuroimaging, and it could allow…

Applications · Statistics 2016-06-16 Stefano Castruccio , Hernando Ombao , Marc G. Genton

Functional magnetic resonance imaging (fMRI) data is characterized by its complexity and high--dimensionality, encompassing signals from various regions of interests (ROIs) that exhibit intricate correlations. Analyzing fMRI data directly…

Applications · Statistics 2024-01-18 Yeseul Jeon , Jeong-Jae Kim , SuMin Yu , Junggu Choi , Sanghoon Han

Data produced by resting-state functional Magnetic Resonance Imaging are widely used to infer brain functional connectivity networks. Such networks correlate neural signals to connect brain regions, which consist in groups of dependent…

Methodology · Statistics 2023-12-05 Hanâ Lbath , Alexander Petersen , Sophie Achard

Recent progress in diffusion MRI and tractography algorithms as well as the launch of the Human Connectome Project (HCP) have provided brain research with an abundance of structural connectivity data. In this work, we describe and evaluate…

Neurons and Cognition · Quantitative Biology 2016-06-02 Kamal Shadi , Saideh Bakhshi , David A. Gutman , Helen S. Mayberg , Constantine Dovrolis

Substantial evidence indicates that major psychiatric disorders are associated with distributed neural dysconnectivity, leading to strong interest in using neuroimaging methods to accurately predict disorder status. In this work, we are…

Machine Learning · Statistics 2014-03-26 Takanori Watanabe , Daniel Kessler , Clayton Scott , Michael Angstadt , Chandra Sripada

Functional brain network has been widely studied to understand the relationship between brain organization and behavior. In this paper, we aim to explore the functional connectivity of brain network under a \emph{multi-step} cognitive task…

Neurons and Cognition · Quantitative Biology 2017-12-06 Shi-Min Cai , Wei Chen , Dong-Bai Liu , Ming Tang , Xun Chen

Functional brain network properties are heavily influenced by how the the network nodes are defined. A common approach uses Regions of Interest (ROIs), i.e., predetermined collections of functional magnetic resonance imaging (fMRI)…

Neurons and Cognition · Quantitative Biology 2025-03-07 Tarmo Nurmi , Pietro De Luca , Maria Hakonen , Mikko Kivelä , Onerva Korhonen

Brain regions are often topographically connected: nearby locations within one brain area connect with nearby locations in another area. Mapping these connection topographies, or 'connectopies' in short, is crucial for understanding how…

Quantitative Methods · Quantitative Biology 2017-07-18 Koen V. Haak , Andre F. Marquand , Christian F. Beckmann

Whole-brain neural connectivity data are now available from viral tracing experiments, which reveal the connections between a source injection site and elsewhere in the brain. These hold the promise of revealing spatial patterns of…

Neurons and Cognition · Quantitative Biology 2016-10-27 Kameron Decker Harris , Stefan Mihalas , Eric Shea-Brown

In recent years, graph neural networks (GNNs) have been widely applied in the analysis of brain fMRI, yet defining the connectivity between ROIs remains a challenge in noisy fMRI data. Among all approaches, Functional Connectome (FC) is the…

Machine Learning · Computer Science 2025-04-09 Jiyao Wang , Nicha C. Dvornek , Peiyu Duan , Lawrence H. Staib , Pamela Ventola , James S. Duncan

Brain structural networks are often represented as discrete adjacency matrices with elements summarizing the connectivity between pairs of regions of interest (ROIs). These ROIs are typically determined a-priori using a brain atlas. The…

Computation · Statistics 2023-08-11 William Consagra , Martin Cole , Xing Qiu , Zhengwu Zhang

Schizophrenia (SZ) is a brain disorder leading to detached mind's normally integrated processes. Hence, the exploration of the symptoms in relation to functional connectivity (FC) had great relevance in the field. FC can be investigated on…

Neurons and Cognition · Quantitative Biology 2026-04-08 Davide Coluzzi , Giuseppe Baselli

There has been increasing interests in learning resting-state brain functional connectivity of autism disorders using functional magnetic resonance imaging (fMRI) data. The data in a standard brain template consist of over 200,000 voxel…

Methodology · Statistics 2016-03-22 Jichun Xie , Jian Kang

Brain activation and connectivity analyses in task-based functional magnetic resonance imaging (fMRI) experiments with multiple subjects are currently at the forefront of data-driven neuroscience. In such experiments, interest often lies in…

Applications · Statistics 2019-04-02 Daniel Spencer , Rajarshi Guhaniyogi , Raquel Prado

Coherence is a widely used measure to assess linear relationships between time series. However, it fails to capture nonlinear dependencies. To overcome this limitation, this paper introduces the notion of residual spectral density as a…

Statistics Theory · Mathematics 2024-05-21 Yuichi Goto , Xuze Zhang , Benjamin Kedem , Shuo Chen
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