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Coarse-grained (CG) molecular models of proteins can substantially increase the time and length scales accessible to molecular dynamics simulations of proteins, but recovery of accurate all-atom (AA) ensembles from CG simulation…

Chemical Physics · Physics 2025-08-06 Alex Berlaga , Michael S. Jones , Andrew L. Ferguson

Gradient based learning using error back-propagation (``backprop'') is a well-known contributor to much of the recent progress in AI. A less obvious, but arguably equally important, ingredient is parameter sharing - most well-known in the…

Machine Learning · Computer Science 2022-11-18 Roland Memisevic

Backpropagation, which uses the chain rule, is the de-facto standard algorithm for optimizing neural networks nowadays. Recently, Hinton (2022) proposed the forward-forward algorithm, a promising alternative that optimizes neural nets…

Machine Learning · Computer Science 2023-05-23 Guy Lorberbom , Itai Gat , Yossi Adi , Alex Schwing , Tamir Hazan

The back-propagation algorithm is the cornerstone of deep learning. Despite its importance, few variations of the algorithm have been attempted. This work presents an approach to discover new variations of the back-propagation equation. We…

Neural and Evolutionary Computing · Computer Science 2018-08-09 Maximilian Alber , Irwan Bello , Barret Zoph , Pieter-Jan Kindermans , Prajit Ramachandran , Quoc Le

Spiking Neural Networks (SNNs) offer a biologically inspired computational paradigm that emulates neuronal activity through discrete spike-based processing. Despite their advantages, training SNNs with traditional backpropagation (BP)…

Neural and Evolutionary Computing · Computer Science 2025-05-28 Mohammadnavid Ghader , Saeed Reza Kheradpisheh , Bahar Farahani , Mahmood Fazlali

The concept of a recently proposed Forward-Forward learning algorithm for fully connected artificial neural networks is applied to a single multi output perceptron for classification. The parameters of the system are trained with respect to…

Machine Learning · Computer Science 2023-04-07 K. Fredrik Karlsson

The human brain performs tasks with an outstanding energy efficiency, i.e., with approximately 20 Watts. The state-of-the-art Artificial/Deep Neural Networks (ANN/DNN), on the other hand, have recently been shown to consume massive amounts…

Machine Learning · Computer Science 2024-09-02 Amin Aminifar , Baichuan Huang , Azra Abtahi , Amir Aminifar

Training a neural network using backpropagation algorithm requires passing error gradients sequentially through the network. The backward locking prevents us from updating network layers in parallel and fully leveraging the computing…

Machine Learning · Computer Science 2019-05-30 Zhouyuan Huo , Bin Gu , Heng Huang

We describe an approximation to backpropagation algorithm for training deep neural networks, which is designed to work with synapses implemented with memristors. The key idea is to represent the values of both the input signal and the…

Neural and Evolutionary Computing · Computer Science 2016-07-28 D. V. Negrov , I. M. Karandashev , V. V. Shakirov , Yu. A. Matveyev , W. L. Dunin-Barkowski , A. V. Zenkevich

The brain processes information through many layers of neurons. This deep architecture is representationally powerful, but it complicates learning by making it hard to identify the responsible neurons when a mistake is made. In machine…

Neurons and Cognition · Quantitative Biology 2014-11-04 Timothy P. Lillicrap , Daniel Cownden , Douglas B. Tweed , Colin J. Akerman

The back-propagation algorithm is widely used for learning in artificial neural networks. A challenge in machine learning is to create models that generalize to new data samples not seen in the training data. Recently, a common flaw in…

Machine Learning · Statistics 2016-04-07 Arild Nøkland

Backpropagation, a foundational algorithm for training artificial neural networks, predominates in contemporary deep learning. Although highly successful, it is widely considered biologically implausible, because it relies on precise…

Machine Learning · Computer Science 2025-10-07 Li Ji-An , Marcus K. Benna

Neural networks are popular state-of-the-art models for many different tasks.They are often trained via back-propagation to find a value of the weights that correctly predicts the observed data. Although back-propagation has shown good…

Machine Learning · Statistics 2020-12-29 Simón Rodríguez Santana , Daniel Hernández-Lobato

Artificial neural networks have been successfully applied to a variety of business application problems involving classification and regression. Although backpropagation neural networks generally predict better than decision trees do for…

Neural and Evolutionary Computing · Computer Science 2010-09-28 S. M. Kamruzzaman , Ahmed Ryadh Hasan

Artificial neural networks are powerful pattern classifiers; however, they have been surpassed in accuracy by methods such as support vector machines and random forests that are also easier to use and faster to train. Backpropagation, which…

Machine Learning · Computer Science 2014-12-31 Mehdi Sajjadi , Mojtaba Seyedhosseini , Tolga Tasdizen

Training of deep neural networks (DNNs) frequently involves optimizing several millions or even billions of parameters. Even with modern computing architectures, the computational expense of DNN training can inhibit, for instance, network…

Machine Learning · Computer Science 2020-06-26 Mauricio E. Tano , Gavin D. Portwood , Jean C. Ragusa

We consider the task of solving generic inverse problems, where one wishes to determine the hidden parameters of a natural system that will give rise to a particular set of measurements. Recently many new approaches based upon deep learning…

Machine Learning · Computer Science 2021-10-13 Simiao Ren , Willie Padilla , Jordan Malof

The artificial neural network is a popular framework in machine learning. To empower individual neurons, we recently suggested that the current type of neurons could be upgraded to 2nd order counterparts, in which the linear operation…

Machine Learning · Computer Science 2017-08-22 Fenglei Fan , Wenxiang Cong , Ge Wang

We propose the predictive forward-forward (PFF) algorithm for conducting credit assignment in neural systems. Specifically, we design a novel, dynamic recurrent neural system that learns a directed generative circuit jointly and…

Machine Learning · Computer Science 2023-04-04 Alexander Ororbia , Ankur Mali

Iterative approximation methods using backpropagation enable the optimization of neural networks, but they remain computationally expensive, especially when used at scale. This paper presents an efficient alternative for optimizing neural…

Machine Learning · Computer Science 2023-11-14 Jake Ryland Williams , Haoran Zhao