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Electron microscopic connectomics is an ambitious research direction with the goal of studying comprehensive brain connectivity maps by using high-throughput, nano-scale microscopy. One of the main challenges in connectomics research is…

Computer Vision and Pattern Recognition · Computer Science 2021-04-14 Tran Minh Quan , David G. C. Hildebrand , Won-Ki Jeong

Brain research has been driven by enquiry for principles of brain structure organization and its control mechanisms. The neuronal wiring map of C. elegans, the only complete connectome available till date, presents an incredible opportunity…

Neurons and Cognition · Quantitative Biology 2016-11-28 Rahul Badhwar , Ganesh Bagler

We analyse the neural dynamics and its relation with the emergent behaviour of a robotic vehicle that is controlled by a neural network numerical simulation based on the nervous system of the nematode Caenorhabditis elegans. The robot…

Neurons and Cognition · Quantitative Biology 2020-11-19 Carlos E. Valencia Urbina , Sergio A. Cannas , Pablo M. Gleiser

Control is essential to the functioning of any neural system. Indeed, under healthy conditions the brain must be able to continuously maintain a tight functional control between the system's inputs and outputs. One may therefore hypothesise…

Neurons and Cognition · Quantitative Biology 2018-05-29 Emma K. Towlson , Petra E. Vertes , Gang Yan , Yee Lian Chew , Denise S. Walker , William R. Schafer , Albert-Laszlo Barabasi

Connectomics is an emerging field in neuroscience that aims to reconstruct the 3-dimensional morphology of neurons from electron microscopy (EM) images. Recent studies have successfully demonstrated the use of convolutional neural networks…

Computer Vision and Pattern Recognition · Computer Science 2017-02-27 Shibani Santurkar , David Budden , Alexander Matveev , Heather Berlin , Hayk Saribekyan , Yaron Meirovitch , Nir Shavit

High-throughput methods for yielding the set of connections in a neural system, the connectome, are now being developed. This tutorial describes ways to analyze the topological and spatial organization of the connectome at the macroscopic…

Neurons and Cognition · Quantitative Biology 2011-12-23 Marcus Kaiser

We exploit flow propagation on the directed neuronal network of the nematode Caenorhabditis elegans to reveal dynamically relevant features of its connectome. We find flow-based groupings of neurons at different levels of granularity, which…

Neurons and Cognition · Quantitative Biology 2016-08-09 Karol A. Bacik , Michael T. Schaub , Mariano Beguerisse-Díaz , Yazan N. Billeh , Mauricio Barahona

While deep neural networks have achieved state-of-the-art performance across a large number of complex tasks, it remains a big challenge to deploy such networks for practical, on-device edge scenarios such as on mobile devices, consumer…

Computer Vision and Pattern Recognition · Computer Science 2019-04-16 Alexander Wong , Zhong Qiu Lin , Brendan Chwyl

The human brain is a complex system, and understanding its mechanisms has been a long-standing challenge in neuroscience. The study of the functional connectome, which maps the functional connections between different brain regions, has…

Neural and Evolutionary Computing · Computer Science 2025-04-14 Tananun Songdechakraiwut , Yutong Wu

This study establishes a benchmark for Caenorhabditis elegans neuron classification, comparing four graph methods (GCN, GraphSAGE, GAT, GraphTransformer) against four non-graph methods (Logistic Regression, MLP, LOLCAT, NeuPRINT). Using the…

Neurons and Cognition · Quantitative Biology 2026-03-04 Jingqi Lu , Keqi Han , Yun Wang , Lu Mi , Carl Yang

We propose a data-driven approach to represent neuronal network dynamics as a Probabilistic Graphical Model (PGM). Our approach learns the PGM structure by employing dimension reduction to network response dynamics evoked by stimuli applied…

Neurons and Cognition · Quantitative Biology 2017-11-02 Hexuan Liu , Jimin Kim , Eli Shlizerman

Network flow is a powerful mathematical framework to systematically explore the relationship between structure and function in biological, social, and technological networks. We introduce a new pipelining model of flow through networks…

Neural and Evolutionary Computing · Computer Science 2019-11-04 Lavanya Marla , Lav R. Varshney , Devavrat Shah , Nirmal A. Prakash , Michael E. Gale

Capturing how the Caenorhabditis elegans connectome structure gives rise to its neuron functionality remains unclear. It is through fiber symmetries found in its neuronal connectivity that synchronization of a group of neurons can be…

Neurons and Cognition · Quantitative Biology 2024-05-07 Bryant Avila , Pedro Augusto , Manuel Zimmer , Matteo Serafino , Hernán A. Makse

The nematode Caenorhabditis elegans, with information on neural connectivity, three-dimensional position and cell linage provides a unique system for understanding the development of neural networks. Although C. elegans has been widely…

Biological Physics · Physics 2011-01-17 Sreedevi Varier , Marcus Kaiser

The detection of cell shape changes in 3D time-lapse images of complex tissues is an important task. However, it is a challenging and tedious task to establish a comprehensive dataset to improve the performance of deep learning models. In…

Image and Video Processing · Electrical Eng. & Systems 2019-06-04 Dali Wang , Zheng Lu , Zhirong Bao

Since their inception, artificial neural networks have relied on manually designed architectures and inductive biases to better adapt to data and tasks. With the rise of deep learning and the expansion of parameter spaces, they have begun…

Neural and Evolutionary Computing · Computer Science 2026-01-28 Weifeng Liu

Individual differences in human intelligence can be modeled and predicted from in vivo neurobiological connectivity. Many established modeling frameworks for predicting intelligence, however, discard higher-order information about…

Neurons and Cognition · Quantitative Biology 2022-03-07 Evan D. Anderson , Ramsey Wilcox , Anuj Nayak , Christopher Zwilling , Pablo Robles-Granda , Been Kim , Lav R. Varshney , Aron K. Barbey

In this era of artificial intelligence, deep neural networks like Convolutional Neural Networks (CNNs) have emerged as front-runners, often surpassing human capabilities. These deep networks are often perceived as the panacea for all…

Computer Vision and Pattern Recognition · Computer Science 2023-11-15 Neeraj Kumar Singh , Nikhil R. Pal

Artificial neural networks which are inspired from the learning mechanism of brain have achieved great successes in many problems, especially those with deep layers. In this paper, we propose a nucleus neural network (NNN) and corresponding…

Computer Vision and Pattern Recognition · Computer Science 2019-05-15 Jia Liu , Maoguo Gong , Haibo He

Deep learning architectures suffer from depth-related performance degradation, limiting the effective depth of neural networks. Approaches like ResNet are able to mitigate this, but they do not completely eliminate the problem. We introduce…

Machine Learning · Computer Science 2023-11-28 Antonio Di Cecco , Carlo Metta , Marco Fantozzi , Francesco Morandin , Maurizio Parton