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We developed a software pipeline for quality control (QC) of histopathology whole slide images (WSIs) that segments various regions, such as blurs of different levels, tissue regions, tissue folds, and pen marks. Given the necessity and…

Image and Video Processing · Electrical Eng. & Systems 2025-06-17 Abhijeet Patil , Garima Jain , Harsh Diwakar , Jay Sawant , Tripti Bameta , Swapnil Rane , Amit Sethi

Accurate classification of Whole Slide Images (WSIs) and Regions of Interest (ROIs) is a fundamental challenge in computational pathology. While mainstream approaches often adopt Multiple Instance Learning (MIL), they struggle to capture…

Computer Vision and Pattern Recognition · Computer Science 2025-08-08 Mingxi Fu , Xitong Ling , Yuxuan Chen , Jiawen Li , fanglei fu , Huaitian Yuan , Tian Guan , Yonghong He , Lianghui Zhu

Semi-supervised domain adaptation (SSDA) is quite a challenging problem requiring methods to overcome both 1) overfitting towards poorly annotated data and 2) distribution shift across domains. Unfortunately, a simple combination of domain…

Computer Vision and Pattern Recognition · Computer Science 2022-12-07 Can Qin , Lichen Wang , Qianqian Ma , Yu Yin , Huan Wang , Yun Fu

Learning Invariant Representations has been successfully applied for reconciling a source and a target domain for Unsupervised Domain Adaptation. By investigating the robustness of such methods under the prism of the cluster assumption, we…

Machine Learning · Computer Science 2020-07-01 Yassine Ouali , Victor Bouvier , Myriam Tami , Céline Hudelot

Automatic segmentation of infection areas in computed tomography (CT) images has proven to be an effective diagnosis approach for COVID-19. However, due to the limited number of pixel-level annotated medical images, accurate segmentation…

Image and Video Processing · Electrical Eng. & Systems 2021-09-13 Han Chen , Yifan Jiang , Murray Loew , Hanseok Ko

Labelling tissue components in histology whole slide images (WSIs) is prohibitively labour-intensive: a single slide may contain tens of thousands of structures--cells, nuclei, and other morphologically distinct objects--each requiring…

Quantitative Methods · Quantitative Biology 2026-04-13 Muhammad Haseeb Ahmad , Sharmila Rajendran , Damion Young , Jon Mason

Deep learning models achieve high accuracy in segmentation tasks among others, yet domain shift often degrades the models' performance, which can be critical in real-world scenarios where no target images are available. This paper proposes…

Computer Vision and Pattern Recognition · Computer Science 2024-09-26 Hiroki Azuma , Yusuke Matsui , Atsuto Maki

This paper presents a novel method for unsupervised segmentation of pathology images. Staging of lung cancer is a major factor of prognosis. Measuring the maximum dimensions of the invasive component in a pathology images is an essential…

Computer Vision and Pattern Recognition · Computer Science 2018-04-13 Takayasu Moriya , Holger R. Roth , Shota Nakamura , Hirohisa Oda , Kai Nagara , Masahiro Oda , Kensaku Mori

Comprehensive semantic segmentation is one of the key components for robust scene understanding and a requirement to enable autonomous driving. Driven by large scale datasets, convolutional neural networks show impressive results on this…

Computer Vision and Pattern Recognition · Computer Science 2019-08-30 Jan-Nico Zaech , Dengxin Dai , Martin Hahner , Luc Van Gool

Multiple instance learning is an ideal mode of analysis for histopathology data, where vast whole slide images are typically annotated with a single global label. In such cases, a whole slide image is modelled as a collection of tissue…

Computer Vision and Pattern Recognition · Computer Science 2023-06-29 Leo Fillioux , Joseph Boyd , Maria Vakalopoulou , Paul-Henry Cournède , Stergios Christodoulidis

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

Quantitative Methods · Quantitative Biology 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He

Objective: We develop a computer-aided diagnosis (CAD) system using deep learning approaches for lesion detection and classification on whole-slide images (WSIs) with breast cancer. The deep features being distinguishing in classification…

Image and Video Processing · Electrical Eng. & Systems 2021-08-29 Wei-Wen Hsu , Yongfang Wu , Chang Hao , Yu-Ling Hou , Xiang Gao , Yun Shao , Xueli Zhang , Tao He , Yanhong Tai

Deep learning frameworks allowed for a remarkable advancement in semantic segmentation, but the data hungry nature of convolutional networks has rapidly raised the demand for adaptation techniques able to transfer learned knowledge from…

Computer Vision and Pattern Recognition · Computer Science 2020-11-26 Marco Toldo , Umberto Michieli , Pietro Zanuttigh

Survival prediction, utilizing pathological images and genomic profiles, is increasingly important in cancer analysis and prognosis. Despite significant progress, precise survival analysis still faces two main challenges: (1) The massive…

Image and Video Processing · Electrical Eng. & Systems 2024-06-26 Songhan Jiang , Zhengyu Gan , Linghan Cai , Yifeng Wang , Yongbing Zhang

Computational analysis of whole slide images (WSIs) has seen significant research progress in recent years, with applications ranging across important diagnostic and prognostic tasks such as survival or cancer subtype prediction. Many…

Computer Vision and Pattern Recognition · Computer Science 2024-11-28 Zak Buzzard , Konstantin Hemker , Nikola Simidjievski , Mateja Jamnik

Automatic outlining of different tissue types in digitized histological specimen provides a basis for follow-up analyses and can potentially guide subsequent medical decisions. The immense size of whole-slide-images (WSI), however, poses a…

The recent prevalence of deep neural networks has lead semantic segmentation networks to achieve human-level performance in the medical field when sufficient training data is provided. Such networks however fail to generalize when tasked…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Serban Stan , Mohammad Rostami

We propose a segmentation framework that uses deep neural networks and introduce two innovations. First, we describe a biophysics-based domain adaptation method. Second, we propose an automatic method to segment white and gray matter, and…

Computer Vision and Pattern Recognition · Computer Science 2018-10-16 Amir Gholami , Shashank Subramanian , Varun Shenoy , Naveen Himthani , Xiangyu Yue , Sicheng Zhao , Peter Jin , George Biros , Kurt Keutzer

Training models dedicated to semantic segmentation requires a large amount of pixel-wise annotated data. Due to their costly nature, these annotations might not be available for the task at hand. To alleviate this problem, unsupervised…

Computer Vision and Pattern Recognition · Computer Science 2022-06-07 Fei Pan , Francois Rameau , Junsik Kim , In So Kweon

Convolutional neural networks (CNNs) have led to significant improvements in the semantic segmentation of images. When source and target datasets come from different modalities, CNN performance suffers due to domain shift. In such cases…

Computer Vision and Pattern Recognition · Computer Science 2022-10-10 Serban Stan , Mohammad Rostami