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This paper presents the first deep reinforcement learning (DRL) framework to estimate the optimal Dynamic Treatment Regimes from observational medical data. This framework is more flexible and adaptive for high dimensional action and state…

Artificial Intelligence · Computer Science 2018-01-30 Ning Liu , Ying Liu , Brent Logan , Zhiyuan Xu , Jian Tang , Yanzhi Wang

Artificial intelligence technology plays a crucial role in recommending prescriptions for traditional Chinese medicine (TCM). Previous studies have made significant progress by focusing on the symptom-herb relationship in prescriptions.…

Artificial Intelligence · Computer Science 2025-09-30 ChaoBo Zhang , Long Tan

Traditional Chinese Medicine (TCM) has accumulated a big amount of precious resource in the long history of development. TCM prescriptions that consist of TCM herbs are an important form of TCM treatment, which are similar to natural…

Computation and Language · Computer Science 2017-11-07 Wei Li , Zheng Yang

Comorbid chronic conditions are common among people with type 2 diabetes. We developed an Artificial Intelligence algorithm, based on Reinforcement Learning (RL), for personalized diabetes and multi-morbidity management with strong…

Computers and Society · Computer Science 2020-11-05 Hua Zheng , Ilya O. Ryzhov , Wei Xie , Judy Zhong

In Traditional Chinese Medicine (TCM), facial features are important basis for diagnosis and treatment. A doctor of TCM can prescribe according to a patient's physical indicators such as face, tongue, voice, symptoms, pulse. Previous works…

Computer Vision and Pattern Recognition · Computer Science 2018-12-18 Huiqiang Liao , Guihua Wen , Yang Hu , Changjun Wang

Traditional Chinese medicine (TCM) has relied on specific combinations of herbs in prescriptions to treat various symptoms and signs for thousands of years. Predicting TCM prescriptions poses a fascinating technical challenge with…

Computation and Language · Computer Science 2024-12-13 Xingzhi Zhou , Xin Dong , Chunhao Li , Yuning Bai , Yulong Xu , Ka Chun Cheung , Simon See , Xinpeng Song , Runshun Zhang , Xuezhong Zhou , Nevin L. Zhang

Owe to the recent advancements in Artificial Intelligence especially deep learning, many data-driven decision support systems have been implemented to facilitate medical doctors in delivering personalized care. We focus on the deep…

Machine Learning · Computer Science 2019-07-24 Siqi Liu , Kee Yuan Ngiam , Mengling Feng

Anatomical changes during intensity-modulated proton therapy (IMPT) for head-and-neck cancer (HNC) can shift Bragg peaks, risking tumor underdosing and organ-at-risk overdosing. Treatment replanning is often required to maintain clinically…

Medical Physics · Physics 2025-08-13 Malvern Madondo , Yuan Shao , Yingzi Liu , Jun Zhou , Xiaofeng Yang , Zhen Tian

The current study applies deep learning to herbalism. Toward the goal, we acquired the de-identified health insurance reimbursements that were claimed in a 10-year period from 2004 to 2013 in the National Health Insurance Database of…

Computation and Language · Computer Science 2017-07-11 Sun-Chong Wang

The goal of precision medicine is to provide individualized treatment at each stage of chronic diseases, a concept formalized by Dynamic Treatment Regimes (DTR). These regimes adapt treatment strategies based on decision rules learned from…

Methodology · Statistics 2025-06-09 Sophia Yazzourh , Nicolas Savy , Philippe Saint-Pierre , Michael R. Kosorok

Dynamic treatment recommendation systems based on large-scale electronic health records (EHRs) become a key to successfully improve practical clinical outcomes. Prior relevant studies recommend treatments either use supervised learning…

Machine Learning · Computer Science 2018-09-18 Lu Wang , Wei Zhang , Xiaofeng He , Hongyuan Zha

Background: Retrieval augmented generation (RAG) technology can empower large language models (LLMs) to generate more accurate, professional, and timely responses without fine tuning. However, due to the complex reasoning processes and…

Computation and Language · Computer Science 2026-02-27 Jianmin Li , Ying Chang , Su-Kit Tang , Yujia Liu , Yanwen Wang , Shuyuan Lin , Binkai Ou

Recent advances in medical large language models have explored Test-Time Reinforcement Learning (TTRL) to enhance reasoning. However, standard TTRL often relies on majority voting (MV) as a heuristic supervision signal, which can be…

Machine Learning · Computer Science 2026-03-11 Kailong Fan , Anqi Pu , Yichen Wu , Wanhua Li , Yicong Li , Hanspeter Pfister , Huafeng Liu , Xiang Li , Quanzheng Li , Ning Guo

We previously proposed an intelligent automatic treatment planning framework for radiotherapy, in which a virtual treatment planner network (VTPN) was built using deep reinforcement learning (DRL) to operate a treatment planning system…

Medical Physics · Physics 2021-06-09 Chenyang Shen , Liyuan Chen , Yesenia Gonzalez , Xun Jia

There has been a continuing demand for traditional and complementary medicine worldwide. A fundamental and important topic in Traditional Chinese Medicine (TCM) is to optimize the prescription and to detect herb regularities from TCM data.…

Quantitative Methods · Quantitative Biology 2020-11-24 Chunyang Ruan , Ye Wang , Yanchun Zhang , Jiangang Ma , Huijuan Chen , Uwe Aickelin , Shanfeng Zhu , Ting Zhang

Reinforcement Learning (RL) can be used to fit a mapping from patient state to a medication regimen. Prior studies have used deterministic and value-based tabular learning to learn a propofol dose from an observed anesthetic state. Deep RL…

Machine Learning · Computer Science 2020-09-10 Gabe Schamberg , Marcus Badgeley , Emery N. Brown

Epilepsy is a prevalent neurological disease with millions of patients worldwide. Many patients have turned to alternative medicine due to the limited efficacy and side effects of conventional antiepileptic drugs. In this study, we…

Neurons and Cognition · Quantitative Biology 2025-05-16 Zhixuan Wang

Clinical diagnostic guidelines outline the key questions to answer to reach a diagnosis. Inspired by guidelines, we aim to develop a model that learns from electronic health records to determine the optimal sequence of actions for accurate…

Traditional Chinese Medicine (TCM) is an influential form of medical treatment in China and surrounding areas. In this paper, we propose a TCM prescription generation task that aims to automatically generate a herbal medicine prescription…

Computation and Language · Computer Science 2018-05-22 Wei Li , Zheng Yang , Xu Sun

Industrial systems demand reliable predictive maintenance strategies to enhance operational efficiency and reduce downtime. This paper introduces an integrated framework that leverages the capabilities of the Transformer model-based neural…

Machine Learning · Computer Science 2024-08-06 Yang Zhao , Jiaxi Yang , Wenbo Wang , Helin Yang , Dusit Niyato
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