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We present a variational Bayesian method of joint image reconstruction and point spread function (PSF) estimation when the PSF of the imaging device is only partially known. To solve this semi-blind deconvolution problem, prior…

Data Analysis, Statistics and Probability · Physics 2013-03-18 Se Un Park , Nicolas Dobigeon , Alfred O. Hero

We address the challenge of training Vision Transformers (ViTs) when labeled data is scarce but unlabeled data is abundant. We propose Semi-Supervised Masked Autoencoder (SSMAE), a framework that jointly optimizes masked image…

Computer Vision and Pattern Recognition · Computer Science 2026-01-29 Atik Faysal , Mohammad Rostami , Reihaneh Gh. Roshan , Nikhil Muralidhar , Huaxia Wang

Pre-training by numerous image data has become de-facto for robust 2D representations. In contrast, due to the expensive data acquisition and annotation, a paucity of large-scale 3D datasets severely hinders the learning for high-quality 3D…

Computer Vision and Pattern Recognition · Computer Science 2022-12-14 Renrui Zhang , Liuhui Wang , Yu Qiao , Peng Gao , Hongsheng Li

Homography estimation is often an indispensable step in many computer vision tasks. The existing approaches, however, are not robust to illumination and/or larger viewpoint changes. In this paper, we propose bidirectional implicit…

Computer Vision and Pattern Recognition · Computer Science 2021-04-21 Daniel Koguciuk , Elahe Arani , Bahram Zonooz

In multi-photon microscopy (MPM), a recent in-vivo fluorescence microscopy system, the task of image restoration can be decomposed into two interlinked inverse problems: firstly, the characterization of the Point Spread Function (PSF) and…

Image and Video Processing · Electrical Eng. & Systems 2024-11-08 Julien Ajdenbaum , Emilie Chouzenoux , Claire Lefort , Ségolène Martin , Jean-Christophe Pesquet

Protein function is inherently linked to its localization within the cell, and fluorescent microscopy data is an indispensable resource for learning representations of proteins. Despite major developments in molecular representation…

Quantitative Methods · Quantitative Biology 2022-05-25 Anastasia Razdaibiedina , Alexander Brechalov

Quantitative imaging methods, such as magnetic resonance fingerprinting (MRF), aim to extract interpretable pathology biomarkers by estimating biophysical tissue parameters from signal evolutions. However, the pattern-matching algorithms or…

Masked Image Modeling (MIM) has achieved promising progress with the advent of Masked Autoencoders (MAE) and BEiT. However, subsequent works have complicated the framework with new auxiliary tasks or extra pre-trained models, inevitably…

Computer Vision and Pattern Recognition · Computer Science 2023-03-27 Yuan Liu , Songyang Zhang , Jiacheng Chen , Kai Chen , Dahua Lin

The development of deep learning models in medical image analysis is majorly limited by the lack of large-sized and well-annotated datasets. Unsupervised learning does not require labels and is more suitable for solving medical image…

Computer Vision and Pattern Recognition · Computer Science 2023-01-06 Zi'an Xu , Yin Dai , Fayu Liu , Weibing Chen , Yue Liu , Lifu Shi , Sheng Liu , Yuhang Zhou

This paper introduces a new method of data-driven microscope design for virtual fluorescence microscopy. Our results show that by including a model of illumination within the first layers of a deep convolutional neural network, it is…

Image and Video Processing · Electrical Eng. & Systems 2020-04-23 Colin L. Cooke , Fanjie Kong , Amey Chaware , Kevin C. Zhou , Kanghyun Kim , Rong Xu , D. Michael Ando , Samuel J. Yang , Pavan Chandra Konda , Roarke Horstmeyer

Integrating domain knowledge into deep learning has emerged as a promising direction for improving model interpretability, generalization, and data efficiency. In this work, we present a novel knowledge-guided ViT-based Masked Autoencoder…

Machine Learning · Computer Science 2026-02-11 Abdul Matin , Rupasree Dey , Tanjim Bin Faruk , Shrideep Pallickara , Sangmi Lee Pallickara

Deep learning models for medical image classification usually achieve promising results but typically rely on large, annotated datasets or standard transfer learning from ImageNet. Self-Supervised Learning (SSL) has emerged as a powerful…

Computer Vision and Pattern Recognition · Computer Science 2026-05-07 Joao Batista Florindo , Amanda Pontes de Oliveira Ornelas

We present PhISM, a physics-informed deep learning architecture that learns without supervision to explicitly disentangle hyperspectral observations and model them with continuous basis functions. PhISM outperforms prior methods on several…

Machine Learning · Computer Science 2026-04-09 Zuzanna Gawrysiak , Krzysztof Krawiec

The point-spread function (PSF) of an imaging system describes the response of the system to a point source. Accurately determining the PSF enables one to correct for the combined effects of focussing and scattering within the imaging…

Instrumentation and Methods for Astrophysics · Physics 2022-11-01 Stefan Johann Hofmeister , Michael Hahn , Daniel Wolf Savin

This paper tries to address a fundamental question in point cloud self-supervised learning: what is a good signal we should leverage to learn features from point clouds without annotations? To answer that, we introduce a point cloud…

Computer Vision and Pattern Recognition · Computer Science 2023-05-16 Xiaoyu Tian , Haoxi Ran , Yue Wang , Hang Zhao

We propose a solution to the image deconvolution problem where the convolution kernel or point spread function (PSF) is assumed to be only partially known. Small perturbations generated from the model are exploited to produce a few…

Data Analysis, Statistics and Probability · Physics 2015-06-04 Se Un Park , Nicolas Dobigeon , Alfred O. Hero

Medical ultrasound provides images which are the spatial map of the tissue echogenicity. Unfortunately, an ultrasound image is a low-quality version of the expected Tissue Reflectivity Function (TRF) mainly due to the non-ideal Point Spread…

Image and Video Processing · Electrical Eng. & Systems 2021-09-28 Sobhan Goudarzi , Hassan Rivaz

Part-level features are crucial for image understanding, but few studies focus on them because of the lack of fine-grained labels. Although unsupervised part discovery can eliminate the reliance on labels, most of them cannot maintain…

Computer Vision and Pattern Recognition · Computer Science 2025-07-17 Jiahao Xia , Yike Wu , Wenjian Huang , Jianguo Zhang , Jian Zhang

We demonstrate that a deep neural network can significantly improve optical microscopy, enhancing its spatial resolution over a large field-of-view and depth-of-field. After its training, the only input to this network is an image acquired…

Machine Learning · Computer Science 2017-11-21 Yair Rivenson , Zoltan Gorocs , Harun Gunaydin , Yibo Zhang , Hongda Wang , Aydogan Ozcan

Scanning Kelvin probe microscopy (SKPM) is a powerful technique for investigating the electrostatic properties of material surfaces, enabling the imaging of variations in work function, topology, surface charge density, or combinations…

Applied Physics · Physics 2024-07-26 Isaac C. D. Lenton , Felix Pertl , Lubuna Shafeek , Scott R. Waitukaitis