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Network motifs are overrepresented interconnection patterns found in real-world networks. What functional advantages may they offer for building complex systems? We show that most network motifs emerge from interconnections patterns that…

Systems and Control · Computer Science 2014-11-21 Marco Tulio Angulo , Yang-Yu Liu , Jean-Jacques Slotine

Network motifs are small building blocks of complex networks. Statistically significant motifs often perform network-specific functions. However, the precise nature of the connection between motifs and the global structure and function of…

Physics and Society · Physics 2015-03-03 Almerima Jamakovic , Priya Mahadevan , Amin Vahdat , Marian Boguna , Dmitri Krioukov

Spatio-temporal network dynamics is an emergent property of many complex systems which remains poorly understood. We suggest a new approach to its study based on the analysis of dynamical motifs -- small subnetworks with periodic and…

Disordered Systems and Neural Networks · Physics 2007-05-23 Valentin P. Zhigulin

Complex networks evolve and vary their structure as time goes by. In particular, the links in those networks have both a sign and a directionality. To understand their structural principles, we measure the network motifs, which are patterns…

Physics and Society · Physics 2023-06-28 Youngjai Park , Mi Jin Lee , Seung-Woo Son

Networks are fundamental for our understanding of complex systems. Interactions between individual nodes in networks generate network motifs - small recurrent patterns that can be considered the network's building-block components,…

Dynamical Systems · Mathematics 2022-09-14 Miri Adler , Ruslan Medzhitov

To any inhibition-dominated threshold-linear network (TLN) we can associate a directed graph that captures the pattern of strong and weak inhibition between neurons. Robust motifs are graphs for which the structure of fixed points in the…

Neurons and Cognition · Quantitative Biology 2019-12-18 Carina Curto , Christopher Langdon , Katherine Morrison

Neural networks storing multiple discrete attractors are canonical models of biological memory. Previously, the dynamical stability of such networks could only be guaranteed under highly restrictive conditions. Here, we derive a theory of…

Disordered Systems and Neural Networks · Physics 2026-01-23 Uri Cohen , Máté Lengyel

The study of motifs in networks can help researchers uncover links between the structure and function of networks in biology, sociology, economics, and many other areas. Empirical studies of networks have identified feedback loops,…

Physics and Society · Physics 2021-05-12 Alice C. Schwarze , Mason A. Porter

Many data analysis problems rely on dynamic networks, such as social or communication network analyses. Providing a scalable overview of long sequences of such dynamic networks remains challenging due to the underlying large-scale data…

Social and Information Networks · Computer Science 2022-08-26 Eren Cakmak , Johannes Fuchs , Dominik Jäckle , Tobias Schreck , Ulrik Brandes , Daniel Keim

Topological features of gene regulatory networks can be successfully reproduced by a model population evolving under selection for short dynamical attractors. The evolved population of networks exhibit motif statistics, summarized by…

Molecular Networks · Quantitative Biology 2016-08-11 Burçin Danacı , Mehmet Ali Anıl , Ayşe Erzan

Networks are a fundamental tool for modeling complex systems in a variety of domains including social and communication networks as well as biology and neuroscience. Small subgraph patterns in networks, called network motifs, are crucial to…

Social and Information Networks · Computer Science 2018-01-08 Ashwin Paranjape , Austin R. Benson , Jure Leskovec

When studying a complex system it is often useful to think of the system as a network of interacting units. One can then ask if some properties of the entire network are already explained by a small part of the network - a network motif. A…

Populations and Evolution · Quantitative Biology 2025-09-03 Melanie Habermann , Ashkaan K. Fahimipour , Justin D. Yeakel , Thilo Gross

Great part of the interest in complex networks has been motivated by the presence of structured, frequently non-uniform, connectivity. Because diverse connectivity patterns tend to result in distinct network dynamics, and also because they…

Disordered Systems and Neural Networks · Physics 2009-11-13 Paulino R. Villas Boas , Francisco A. Rodrigues , Gonzalo Travieso , Luciano da F. Costa

Networks are abundant in biological systems. Small sized over-represented network motifs have been discovered, and it has been suggested that these constitute functional building blocks. We ask whether larger dynamical network motifs exist…

Neural and Evolutionary Computing · Computer Science 2018-09-25 C. H. Huck Yang , Rise Ooi , Tom Hiscock , Victor Eguiluz , Jesper Tegnér

Network science can offer fundamental insights into the structural and functional properties of complex systems. For example, it is widely known that neuronal circuits tend to organize into basic functional topological modules, called…

Adaptation and Self-Organizing Systems · Physics 2022-08-03 Matteo Zambra , Alberto Testolin , Amos Maritan

Many observables of brain dynamics appear to be optimized for computation. Which connectivity structures underlie this fine-tuning? We propose that many of these structures are naturally encoded in the space that more directly relates to…

Disordered Systems and Neural Networks · Physics 2023-09-18 Lorenzo Tiberi , David Dahmen , Moritz Helias

Discrete dynamic models are a powerful tool for the understanding and modeling of large biological networks. Although a lot of progress has been made in developing analysis tools for these models, there is still a need to find approaches…

Molecular Networks · Quantitative Biology 2013-06-14 Jorge G. T. Zañudo , Réka Albert

Network motifs are often called the building blocks of networks. Analysis of motifs is found to be an indispensable tool for understanding local network structure, in contrast to measures based on node degree distribution and its functions…

Physics and Society · Physics 2017-08-23 Asim Kumer Dey , Yulia R. Gel , H. Vincent Poor

A determinant property of the structure of a biological network is the distribution of local connectivity patterns, i.e., network motifs. In this work, a method for creating directed, unweighted networks while promoting a certain…

Social and Information Networks · Computer Science 2016-07-29 Tuomo Mäki-Marttunen

Network motifs are patterns of over-represented node interactions in a network which have been previously used as building blocks to understand various aspects of the social networks. In this paper, we use motif patterns to characterize the…

Social and Information Networks · Computer Science 2019-03-05 Soumajyoti Sarkar , Ruocheng Guo , Paulo Shakarian
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