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Single-cell datasets often lack individual cell labels, making it challenging to identify cells associated with disease. To address this, we introduce Mixture Modeling for Multiple Instance Learning (MMIL), an expectation maximization…

Quantitative Methods · Quantitative Biology 2024-06-13 Erin Craig , Timothy Keyes , Jolanda Sarno , Maxim Zaslavsky , Garry Nolan , Kara Davis , Trevor Hastie , Robert Tibshirani

Deep Metric Learning (DML) methods have been proven relevant for visual similarity learning. However, they sometimes lack generalization properties because they are trained often using an inappropriate sample selection strategy or due to…

Computer Vision and Pattern Recognition · Computer Science 2022-06-07 Jorge Gonzalez-Zapata , Ivan Reyes-Amezcua , Daniel Flores-Araiza , Mauricio Mendez-Ruiz , Gilberto Ochoa-Ruiz , Andres Mendez-Vazquez

In recent years, the integration of pre-trained foundational models with multiple instance learning (MIL) has improved diagnostic accuracy in computational pathology. However, existing MIL methods focus on optimizing feature extractors and…

Computer Vision and Pattern Recognition · Computer Science 2025-12-24 Le Feng , Li Xiao

Multi-instance learning (MIL) deals with objects represented as bags of instances and can predict instance labels from bag-level supervision. However, significant performance gaps exist between instance-level MIL algorithms and supervised…

Machine Learning · Computer Science 2022-10-06 Weijia Zhang , Xuanhui Zhang , Han-Wen Deng , Min-Ling Zhang

Hierarchical Imitation Learning (HIL) is an effective way for robots to learn sub-skills from long-horizon unsegmented demonstrations. However, the learned hierarchical structure lacks the mechanism to transfer across multi-tasks or to new…

Robotics · Computer Science 2022-02-22 Chongkai Gao , Yizhou Jiang , Feng Chen

Multimodal biomedical Vision-Language Models (VLMs) exhibit immense potential in the field of Continual Learning (CL). However, they confront a core dilemma: how to preserve fine-grained intra-modality features while bridging the…

Computer Vision and Pattern Recognition · Computer Science 2025-12-16 Zizhi Chen , Yizhen Gao , Minghao Han , Yizhou Liu , Zhaoyu Chen , Dingkang Yang , Lihua Zhang

With the increasing demand for histopathological specimen examination and diagnostic reporting, Multiple Instance Learning (MIL) has received heightened research focus as a viable solution for AI-centric diagnostic aid. Recently, to improve…

Computer Vision and Pattern Recognition · Computer Science 2025-12-25 Sungrae Hong , Sol Lee , Jisu Shin , Jiwon Jeong , Mun Yong Yi

Confusion and forgetting of object classes have been challenges of prime interest in Few-Shot Object Detection (FSOD). To overcome these pitfalls in metric learning based FSOD techniques, we introduce a novel Submodular Mutual Information…

Computer Vision and Pattern Recognition · Computer Science 2024-09-18 Anay Majee , Ryan Sharp , Rishabh Iyer

Multimodal Deep Learning has garnered much interest, and transformers have triggered novel approaches, thanks to the cross-attention mechanism. Here we propose an approach to deal with two key existing challenges: the high computational…

Machine Learning · Computer Science 2021-10-20 Dhruv Agarwal , Tanay Agrawal , Laura M. Ferrari , François Bremond

Knowledge distillation is an effective method to transfer the knowledge from the cumbersome teacher model to the lightweight student model. Online knowledge distillation uses the ensembled prediction results of multiple student models as…

Computer Vision and Pattern Recognition · Computer Science 2020-11-16 Zheng Li , Ying Huang , Defang Chen , Tianren Luo , Ning Cai , Zhigeng Pan

Deep learning models have revolutionized the field of medical image analysis, due to their outstanding performances. However, they are sensitive to spurious correlations, often taking advantage of dataset bias to improve results for…

Computer Vision and Pattern Recognition · Computer Science 2024-05-06 Diogo J. Araújo , M. Rita Verdelho , Alceu Bissoto , Jacinto C. Nascimento , Carlos Santiago , Catarina Barata

Recently, Multimodal Learning (MML) has gained significant interest as it compensates for single-modality limitations through comprehensive complementary information within multimodal data. However, traditional MML methods generally use the…

Computer Vision and Pattern Recognition · Computer Science 2024-07-30 Yunfeng Fan , Wenchao Xu , Haozhao Wang , Junhong Liu , Song Guo

Diffusion models (DMs) have demonstrated exceptional generative capabilities across various domains, including image, video, and so on. A key factor contributing to their effectiveness is the high quantity and quality of data used during…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Qianlong Xiang , Miao Zhang , Yuzhang Shang , Jianlong Wu , Yan Yan , Liqiang Nie

Multimodal learning has increasingly become a focal point in research, primarily due to its ability to integrate complementary information from diverse modalities. Nevertheless, modality imbalance, stemming from factors such as insufficient…

Machine Learning · Computer Science 2025-11-04 Rongrong Xie , Guido Sanguinetti

Digitizing pathological images into gigapixel Whole Slide Images (WSIs) has opened new avenues for Computational Pathology (CPath). As positive tissue comprises only a small fraction of gigapixel WSIs, existing Multiple Instance Learning…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Wenhao Tang , Sheng Huang , Heng Fang , Fengtao Zhou , Bo Liu , Qingshan Liu

Imitation Learning (IL), also referred to as Learning from Demonstration (LfD), holds significant promise for capturing expert motor skills through efficient imitation, facilitating adept navigation of complex scenarios. A persistent…

Robotics · Computer Science 2024-04-01 Yingbai Hu , Fares J. Abu-Dakka , Fei Chen , Xiao Luo , Zheng Li , Alois Knoll , Weiping Ding

Although multi-instance learning (MIL) has succeeded in pathological image classification, it faces the challenge of high inference costs due to the need to process thousands of patches from each gigapixel whole slide image (WSI). To…

Computer Vision and Pattern Recognition · Computer Science 2025-08-08 Jiuyang Dong , Jiahan Li , Junjun Jiang , Kui Jiang , Yongbing Zhang

Multiple Instance Learning (MIL) is a weak supervision learning paradigm that allows modeling of machine learning problems in which labels are available only for groups of examples called bags. A positive bag may contain one or more…

Machine Learning · Computer Science 2019-10-29 Amina Asif , Fayyaz ul Amir Afsar Minhas

Attention-based multiple instance learning (MIL) has emerged as a powerful framework for whole slide image (WSI) diagnosis, leveraging attention to aggregate instance-level features into bag-level predictions. Despite this success, we find…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Linfeng Ye , Shayan Mohajer Hamidi , Zhixiang Chi , Guang Li , Mert Pilanci , Takahiro Ogawa , Miki Haseyama , Konstantinos N. Plataniotis

Language model continual learning (CL) has recently attracted significant interest for its ability to adapt large language models (LLMs) to dynamic real-world scenarios without retraining. A major challenge in this domain is catastrophic…

Computation and Language · Computer Science 2025-01-24 Yujie Feng , Xu Chu , Yongxin Xu , Zexin Lu , Bo Liu , Philip S. Yu , Xiao-Ming Wu
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