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In radiotherapy, 2D orthogonally projected kV images are used for patient alignment when 3D-on-board imaging(OBI) unavailable. But tumor visibility is constrained due to the projection of patient's anatomy onto a 2D plane, potentially…

Background: Voxel-based analysis (VBA) for population level radiotherapy (RT) outcomes modeling requires topology preserving inter-patient deformable image registration (DIR) that preserves tumors on moving images while avoiding unrealistic…

Early detection of lung nodules with computed tomography (CT) is critical for the longer survival of lung cancer patients and better quality of life. Computer-aided detection/diagnosis (CAD) is proven valuable as a second or concurrent…

Computer Aided Diagnosis has emerged as an indispensible technique for validating the opinion of radiologists in CT interpretation. This paper presents a deep 3D Convolutional Neural Network (CNN) architecture for automated CT scan-based…

Purpose: To develop an algorithm for real-time volumetric image reconstruction and 3D tumor localization based on a single x-ray projection image for lung cancer radiotherapy. Methods: Given a set of volumetric images of a patient at N…

Early detection of lung cancer is crucial for effective treatment and relies on accurate volumetric assessment of pulmonary nodules in CT scans. Traditional methods, such as consolidation-to-tumor ratio (CTR) and spherical approximation,…

In recent years, deep-learning-based image processing has emerged as a valuable tool for medical imaging owing to its high performance. However, the quality of deep-learning-based methods heavily relies on the amount of training data; the…

This study investigates the use of the unsupervised deep learning framework VoxelMorph for deformable registration of longitudinal abdominopelvic CT images acquired in patients with bone metastases from breast cancer. The CT images were…

Computed Tomography (CT) imaging technique is widely used in geological exploration, medical diagnosis and other fields. In practice, however, the resolution of CT image is usually limited by scanning devices and great expense. Super…

Background and Purpose: Convolutional neural network is widely used for image recognition in the medical area at nowadays. However, overall accuracy in predicting lung tumor is low and the processing time is high as the error occurred while…

Purpose: Radiotherapy presents unique challenges and clinical requirements for longitudinal tumor and organ-at-risk (OAR) prediction during treatment. The challenges include tumor inflammation/edema and radiation-induced changes in organ…

Due to the inter- and intra- variation of respiratory motion, it is highly desired to provide real-time volumetric images during the treatment delivery of lung stereotactic body radiation therapy (SBRT) for accurate and active motion…

The purpose of this study is to develop a deep learning based method that can automatically generate segmentations on cone-beam CT (CBCT) for head and neck online adaptive radiation therapy (ART), where expert-drawn contours in planning CT…

We present a technique for continuous generation of volumetric images during SBRT using periodic kV imaging and an external respiratory surrogate signal to drive a patient-specific PCA motion model. Using the on-board imager, kV radiographs…

Medical image registration is one of the key processing steps for biomedical image analysis such as cancer diagnosis. Recently, deep learning based supervised and unsupervised image registration methods have been extensively studied due to…

Deformable registration of two-dimensional/three-dimensional (2D/3D) images of abdominal organs is a complicated task because the abdominal organs deform significantly and their contours are not detected in two-dimensional X-ray images. We…

We propose Deep-Motion-Net: an end-to-end graph neural network (GNN) architecture that enables 3D (volumetric) organ shape reconstruction from a single in-treatment kV planar X-ray image acquired at any arbitrary projection angle.…

Since, cancer is curable when diagnosed at an early stage, lung cancer screening plays an important role in preventive care. Although both low dose computed tomography (LDCT) and computed tomography (CT) scans provide more medical…

Computer-aided diagnosis for low-dose computed tomography (CT) based on deep learning has recently attracted attention as a first-line automatic testing tool because of its high accuracy and low radiation exposure. However, existing methods…

Lung cancer is a very deadly disease worldwide, and its early diagnosis is crucial for increasing patient survival rates. Computed tomography (CT) scans are widely used for lung cancer diagnosis as they can give detailed lung structures.…