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Self-driving labs (SDLs) combine fully automated experiments with artificial intelligence (AI) that decides the next set of experiments. Taken to their ultimate expression, SDLs could usher a new paradigm of scientific research, where the…

The emergence of Self-Driving Laboratories (SDLs) transforms scientific discovery methodology by integrating AI with robotic automation to create closed-loop experimental systems capable of autonomous hypothesis generation, experimentation,…

Robotics · Computer Science 2026-02-18 Zihan Zhang , Haohui Que , Junhan Chang , Xin Zhang , Hao Wei , Tong Zhu

Self-driving labs are transforming drug discovery by enabling automated, AI-guided experimentation, but they face challenges in orchestrating complex workflows, integrating diverse instruments and AI models, and managing data efficiently.…

Software Engineering · Computer Science 2025-04-02 Yao Fehlis , Paul Mandel , Charles Crain , Betty Liu , David Fuller

A key goal of modern materials science is accelerating the pace of materials discovery. Self-driving labs, or systems that select experiments using machine learning and then execute them using automation, are designed to fulfil this promise…

Computational Physics · Physics 2025-08-12 Adedire D. Adesiji , Jiashuo Wang , Cheng-Shu Kuo , Keith A. Brown

Science laboratory automation enables accelerated discovery in life sciences and materials. However, it requires interdisciplinary collaboration to address challenges such as robust and flexible autonomy, reproducibility, throughput,…

Automated Driving Systems (ADS) hold great potential to increase safety, mobility, and equity. However, without public acceptance, none of these promises can be fulfilled. To engender public trust, many entities in the ADS community…

Computers and Society · Computer Science 2023-07-03 Scott Schnelle , Francesca M. Favaro

Research with AI and ML technologies lives in a variety of settings with often asynchronous goals and timelines: academic labs and government organizations pursue open-ended research focusing on discoveries with long-term value, while…

Instrumentation and Methods for Astrophysics · Physics 2021-02-17 Siddha Ganju , Anirudh Koul , Alexander Lavin , Josh Veitch-Michaelis , Meher Kasam , James Parr

Self-driving laboratories (SDLs) close the loop between experiment design, automated execution, and data-driven decision making, and they provide a demanding testbed for agentic AI under expensive actions, noisy and delayed feedback, strict…

Artificial Intelligence · Computer Science 2026-01-27 Xuanzhou Chen , Audrey Wang , Stanley Yin , Hanyang Jiang , Dong Zhang

Since the 2004 DARPA Grand Challenge, the autonomous driving technology has witnessed nearly two decades of rapid development. Particularly, in recent years, with the application of new sensors and deep learning technologies extending to…

Cryptography and Security · Computer Science 2022-10-21 Hui Cao , Wenlong Zou , Yinkun Wang , Ting Song , Mengjun Liu

Self-driving laboratories (SDLs) are rapidly transforming research in chemistry and materials science to accelerate new discoveries. Mobile robot chemists (MRCs) play a pivotal role by autonomously navigating the lab to transport samples,…

Modern scientific discovery increasingly requires coordinating distributed facilities and heterogeneous resources, forcing researchers to act as manual workflow coordinators rather than scientists. Advances in AI leading to AI agents show…

Artificial Intelligence · Computer Science 2025-09-15 Woong Shin , Renan Souza , Daniel Rosendo , Frédéric Suter , Feiyi Wang , Prasanna Balaprakash , Rafael Ferreira da Silva

Scientific discovery has long been constrained by human limitations in expertise, physical capability, and sleep cycles. The recent rise of AI scientists and automated laboratories has accelerated both the cognitive and operational aspects…

Self-driving laboratories (SDLs), by combining automation with machine learning-guided experiment selection, have the potential to transform experimental materials science. To date, most SDLs have been optimisation-driven, designed to…

Materials Science · Physics 2026-03-24 Jonathan Staaf Scragg

The promise of autonomous scientific discovery (ASD) hinges not only on answering questions, but also on knowing which questions to ask. Most recent works in ASD explore the use of large language models (LLMs) in goal-driven settings,…

Automated driving systems (ADSs) promise a safe, comfortable and efficient driving experience. However, fatalities involving vehicles equipped with ADSs are on the rise. The full potential of ADSs cannot be realized unless the robustness of…

Robotics · Computer Science 2020-04-06 Ekim Yurtsever , Jacob Lambert , Alexander Carballo , Kazuya Takeda

Self Driving Labs (SDLs) that combine automation of experimental procedures with autonomous decision making are gaining popularity as a means of increasing the throughput of scientific workflows. The task of identifying quantities of…

This paper explores the emerging knowledge-driven autonomous driving technologies. Our investigation highlights the limitations of current autonomous driving systems, in particular their sensitivity to data bias, difficulty in handling…

With their potential to significantly reduce traffic accidents, enhance road safety, optimize traffic flow, and decrease congestion, autonomous driving systems are a major focus of research and development in recent years. Beyond these…

Robotics · Computer Science 2024-11-18 Xu Wang , Mohammad Ali Maleki , Muhammad Waqar Azhar , Pedro Trancoso

Self-driving laboratories (SDLs) consist of multiple stations that perform material synthesis and characterisation tasks. To minimize station downtime and maximize experimental throughput, it is practical to run experiments in asynchronous…

Machine Learning · Computer Science 2023-12-07 Hao Wen , Jakob Zeitler , Connor Rupnow

The Frontier Development Lab (FDL) is a National Aeronautics and Space Administration (NASA) machine learning program with the stated aim of conducting artificial intelligence research for space exploration and all humankind with support in…

Instrumentation and Methods for Astrophysics · Physics 2019-12-20 Luís F. Simões , Ben Day , Vinutha M. Shreenath , Callum Wilson , Chris Bridges , Sylvester Kaczmarek , Yarin Gal
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