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Cold atmospheric plasma (CAP) has been emerged as a novel technology for cancer treatment. CAP can directly treat cells and tissue but such direct application is limited to skin or can be invoked as a supplement during open surgery. In this…

Medical Physics · Physics 2016-12-21 Zhitong Chen , Xiaoqian Cheng , Li Lin , Michael Keidar

Cold atmospheric plasma (CAP) has shown its promising application in cancer treatment both in vitro and in vivo. However, the anti-cancer mechanism is still largely unknown. CAP may kill cancer cells via triggering the rise of intracellular…

Cell Behavior · Quantitative Biology 2017-11-27 Dayun Yan , Jonathan H. Sherman , Jerome Canady , Barry Trink , Michael Keidar

Through the last decade, cold atmospheric plasma (CAP) has emerged as an innovative therapeutic option for cancer treatment. Recently, we have set up a potentially safe atmospheric pressure plasma jet device that displays antitumoral…

Cold atmospheric plasma (CAP) is a near room temperature ionized gas, generated under non-equilibrium discharge conditions. Here we show that a short exposure of rat peritoneal exudate macrophages and T-cells to CAP in vitro, triggered an…

Medical Physics · Physics 2022-02-01 Fengdong Cheng , Dayun Yan , Jie Chen , Zi Wang , Alex Horkowitz , Michael Keidar , Eduardo M. Sotomayor

Cold atmospheric plasma (CAP) is a promising new agent for (selective) cancer treatment, but the underlying cause of the anti-cancer effect of CAP is not well understood yet. Among different theories and observations, one theory in…

Molecular Networks · Quantitative Biology 2020-10-28 Charlotta Bengtson , Annemie Bogaerts

Micro-sized cold atmospheric plasma (uCAP) has been developed to expand the applications of CAP in cancer therapy. In this paper, uCAP devices with different nozzle lengths were applied to investigate effects on both brain (glioblastoma…

Tissues and Organs · Quantitative Biology 2018-04-24 Zhitong Chen , Li Lin , Qinmin Zheng , Jonathan H. Sherman , Jerome Canady , Barry Trink , Michael Keidar

Cold atmospheric plasma (CAP) was shown to affect cells not only directly, but also indirectly by means of plasma pre-treated solution. This study investigated a new application of CAP generated in deionized (DI) water for the cancer…

Medical Physics · Physics 2016-10-17 Zhitong Chen , Li Lin , Xiaoqian Cheng , Eda Gjika , Michael Keidar

For years, extensive efforts have been made to discover effective, non-invasive anti-cancer therapies. Cold atmospheric plasma (CAP), is a near room temperature ionized gas composed of reactive species, charged particles, neutral particles,…

Hydrogen peroxide (H2O2) is an important signaling molecule in cancer cells. However, the significant secretion of H2O2 by cancer cells have been rarely observed. Cold atmospheric plasma (CAP) is a near room temperature ionized gas composed…

Cell Behavior · Quantitative Biology 2017-07-04 Dayun Yan , Haitao Cui , Wei Zhu , Annie Talbot , Lijie Grace Zhang , Jonathan H. Sherman , Michael Keidar

Plasma activated medium, containing reactive oxygen species (ROS) and reactive nitrogen species (RNS), has been used for cancer treatment as an indirect treatment method. Here we report cold atmospheric plasma (CAP) activated deionized (DI)…

Biological Physics · Physics 2022-03-14 Zhitong Chen

Inactivation of microorganisms on sensitive surfaces by cold atmospheric plasma (CAP) is one major application in the field of plasma medicine because it provides a simple and effective way to sterilize heat-sensitive materials. Therefore,…

Plasma Physics · Physics 2020-08-26 Sandra Moritz , Alisa Schmidt , Joachim Sann , M. H. Thoma

Plasma medicine is an emerging and innovative interdisciplinary research field combining biology, chemistry, physics, engineering, and medicine. However, the safe clinical application of cold atmospheric plasma (CAP) technology is still a…

Medical Physics · Physics 2023-05-31 Zhitong Chen , Richard Obenchain , Richard E. Wirz

Non-thermal atmospheric plasma (NTAP) can be applied to living tissues and cells as a novel technology for cancer therapy. Even though studies report on the successful use of NTAP to directly irradiate cancer cells, this technology can…

Tissues and Organs · Quantitative Biology 2016-09-09 Zhitong Chen , Li Lin , Xiaoqian Cheng , Eda Gjika , Michael Keidar

Atmospheric pressure plasma jets (APPJ) are investigated as an efficient approach to induce antitumor effects of cancerous tissues without inducing any damage (e.g. dessication, burnings). For this, a two-steps methodology has been…

Medical Physics · Physics 2019-12-03 F. Judee , J. Vaquero , L. Fouassier , T. Dufour

Studies on the interaction of plasma generated at atmospheric pressure and at room temperature (low temperature plasma or just cold plasma) with biological cells and tissues have revealed that cold plasma has therapeutic effects that form…

Medical Physics · Physics 2021-06-04 Mounir Laroussi

Cold atmospheric plasmas (CAP) are weakly ionized gases that can be generated in ambient air. They produce energetic species (e.g. electrons, metastables) as well as reactive oxygen species, reactive nitrogen species, UV radiations and…

Applied Physics · Physics 2018-02-21 Florian Judée , Stéphane Simon , Christophe Bailly , Thierry Dufour

Despite advancements in lung cancer therapy, the prognosis for advanced or metastatic patients remains poor, yet many patients eventually develop resistance to standard treatments leading to disease progression and poor survival. Here, we…

Biological Physics · Physics 2024-08-23 Yueye Huang , Rui Zhang , Xiao Chen , Fei Cao , Qiujie Fang , Qingnan Xu , Shicong Huang , Yufan Wang , Guojun Chen , Zhitong Chen

Plasma treatment increases the surface energy of condensed phases: solids and liquids. Two independent methods of the quantification of the influence imposed by a cold radiofrequency air plasma treatment on the surface properties of…

Experiments have revealed a nontrivial cancer-inhibiting capability of liquid media treated by the plasma jet capable of forming thinly stratified self-organized patterns at a plasma-liquid interface. A pronounced cancer depressing activity…

Medical Physics · Physics 2017-01-09 Zhitong Chen , Shiqiang Zhang , Igor Levchenko , Isak I. Beilis , Michael Keidar

Efficient and biologically safe mode of cold atmospheric plasma jet (CAPJ) is crucial for the development of CAPJ-based anticancer therapy. In the experiment and numerical simulations, by changing the pulse duration of a positive-pulsed…

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