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We present a keypoint-based foundation model for general purpose brain MRI registration, based on the recently-proposed KeyMorph framework. Our model, called BrainMorph, serves as a tool that supports multi-modal, pairwise, and scalable…

Computer Vision and Pattern Recognition · Computer Science 2025-06-10 Alan Q. Wang , Rachit Saluja , Heejong Kim , Xinzi He , Adrian Dalca , Mert R. Sabuncu

In the field of medical image analysis, image registration is a crucial technique. Despite the numerous registration models that have been proposed, existing methods still fall short in terms of accuracy and interpretability. In this paper,…

Computer Vision and Pattern Recognition · Computer Science 2024-10-25 Jiaofen Nan , Gaodeng Fan , Kaifan Zhang , Chen Zhao , Fubao Zhu , Weihua Zhou

Affine image registration is a cornerstone of medical image analysis. While classical algorithms can achieve excellent accuracy, they solve a time-consuming optimization for every image pair. Deep-learning (DL) methods learn a function that…

Image and Video Processing · Electrical Eng. & Systems 2024-07-15 Malte Hoffmann , Andrew Hoopes , Douglas N. Greve , Bruce Fischl , Adrian V. Dalca

Deformable image registration can obtain dynamic information about images, which is of great significance in medical image analysis. The unsupervised deep learning registration method can quickly achieve high registration accuracy without…

Computer Vision and Pattern Recognition · Computer Science 2022-07-19 Xiao Fan , Shuxin Zhuang , Zhemin Zhuang , Ye Yuan , Shunmin Qiu , Alex Noel Joseph Raj , Yibiao Rong

This paper introduces GeoMorph, a novel geometric deep-learning framework designed for image registration of cortical surfaces. The registration process consists of two main steps. First, independent feature extraction is performed on each…

Machine Learning · Computer Science 2023-11-23 Mohamed A. Suliman , Logan Z. J. Williams , Abdulah Fawaz , Emma C. Robinson

We present HyperMorph, a learning-based strategy for deformable image registration that removes the need to tune important registration hyperparameters during training. Classical registration methods solve an optimization problem to find a…

Computer Vision and Pattern Recognition · Computer Science 2021-05-06 Andrew Hoopes , Malte Hoffmann , Bruce Fischl , John Guttag , Adrian V. Dalca

We present VoxelMorph, a fast learning-based framework for deformable, pairwise medical image registration. Traditional registration methods optimize an objective function for each pair of images, which can be time-consuming for large…

Computer Vision and Pattern Recognition · Computer Science 2019-09-04 Guha Balakrishnan , Amy Zhao , Mert R. Sabuncu , John Guttag , Adrian V. Dalca

We introduce HyperMorph, a framework that facilitates efficient hyperparameter tuning in learning-based deformable image registration. Classical registration algorithms perform an iterative pair-wise optimization to compute a deformation…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Andrew Hoopes , Malte Hoffmann , Douglas N. Greve , Bruce Fischl , John Guttag , Adrian V. Dalca

Conventional deformable registration methods aim at solving an optimization model carefully designed on image pairs and their computational costs are exceptionally high. In contrast, recent deep learning based approaches can provide fast…

Computer Vision and Pattern Recognition · Computer Science 2021-10-01 Risheng Liu , Zi Li , Xin Fan , Chenying Zhao , Hao Huang , Zhongxuan Luo

Image registration is a fundamental task in medical image analysis. Recently, deep learning based image registration methods have been extensively investigated due to their excellent performance despite the ultra-fast computational time.…

Computer Vision and Pattern Recognition · Computer Science 2020-08-14 Boah Kim , Dong Hwan Kim , Seong Ho Park , Jieun Kim , June-Goo Lee , Jong Chul Ye

Deformable image registration poses a challenging problem where, unlike most deep learning tasks, a complex relationship between multiple coordinate systems has to be considered. Although data-driven methods have shown promising…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Vasiliki Sideri-Lampretsa , Nil Stolt-Ansó , Huaqi Qiu , Julian McGinnis , Wenke Karbole , Martin Menten , Daniel Rueckert

Deformable image registration is one of the fundamental tasks in medical imaging. Classical registration algorithms usually require a high computational cost for iterative optimizations. Although deep-learning-based methods have been…

Image and Video Processing · Electrical Eng. & Systems 2022-09-30 Boah Kim , Inhwa Han , Jong Chul Ye

Many real-world settings require registration of a pair of medical images that differ in spatial resolution, which may arise from differences in image acquisition parameters like pixel spacing, slice thickness, and field-of-view. However,…

Computer Vision and Pattern Recognition · Computer Science 2025-07-15 Mina C. Moghadam , Alan Q. Wang , Omer Taub , Martin R. Prince , Mert R. Sabuncu

The correlation of optical measurements with a correct pathology label is often hampered by imprecise registration caused by deformations in histology images. This study explores an automated multi-modal image registration technique…

Image and Video Processing · Electrical Eng. & Systems 2023-11-27 Lianne Feenstra , Maud Lambregts , Theo J. M Ruers , Behdad Dashtbozorg

The majority of current research in deep learning based image registration addresses inter-patient brain registration with moderate deformation magnitudes. The recent Learn2Reg medical registration benchmark has demonstrated that…

Computer Vision and Pattern Recognition · Computer Science 2022-03-02 Mattias P. Heinrich , Lasse Hansen

Diffeomorphic deformable multi-modal image registration is a challenging task which aims to bring images acquired by different modalities to the same coordinate space and at the same time to preserve the topology and the invertibility of…

Image and Video Processing · Electrical Eng. & Systems 2022-03-16 Vasiliki Sideri-Lampretsa , Georgios Kaissis , Daniel Rueckert

Diffeomorphic image registration, offering smooth transformation and topology preservation, is required in many medical image analysis tasks.Traditional methods impose certain modeling constraints on the space of admissible transformations…

Computer Vision and Pattern Recognition · Computer Science 2022-11-03 Kun Han , Shanlin sun , Xiangyi Yan , Chenyu You , Hao Tang , Junayed Naushad , Haoyu Ma , Deying Kong , Xiaohui Xie

Diffeomorphic deformable image registration is crucial in many medical image studies, as it offers unique, special properties including topology preservation and invertibility of the transformation. Recent deep learning-based deformable…

Computer Vision and Pattern Recognition · Computer Science 2021-03-02 Tony C. W. Mok , Albert C. S. Chung

Image registration is a key technique in medical image analysis to estimate deformations between image pairs. A good deformation model is important for high-quality estimates. However, most existing approaches use ad-hoc deformation models…

Computer Vision and Pattern Recognition · Computer Science 2019-04-23 Marc Niethammer , Roland Kwitt , Francois-Xavier Vialard

Deformable image registration plays a fundamental role in medical image analysis by enabling spatial alignment of anatomical structures across subjects. While recent deep learning-based approaches have significantly improved computational…

Image and Video Processing · Electrical Eng. & Systems 2026-03-24 Jiaqi Shang , Haojin Wu , Yinyi Lai , Zongyu Li , Chenghao Zhang , Jia Guo
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