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It seems that in the current age, computers, computation, and data have an increasingly important role to play in scientific research and discovery. This is reflected in part by the rise of machine learning and artificial intelligence,…

Machine Learning · Computer Science 2024-05-15 Ronan Keane

Molecular docking is a critical computational method in drug discovery used to predict the binding conformation and orientation of a ligand within a protein's binding site. Mapping this challenge onto a graph-based problem, specifically the…

Quantum Physics · Physics 2026-04-27 Mathieu Garrigues , Victor Onofre , Wesley Coelho , S. Acheche

Support Vector Machines (SVMs) are well-established Machine Learning (ML) algorithms. They rely on the fact that i) linear learning can be formalized as a well-posed optimization problem; ii) non-linear learning can be brought into linear…

Artificial Intelligence · Computer Science 2016-08-16 Christian Gagné , Marc Schoenauer , Michèle Sebag , Marco Tomassini

Quantum graphical models (QGMs) extend the classical framework for reasoning about uncertainty by incorporating the quantum mechanical view of probability. Prior work on QGMs has focused on hidden quantum Markov models (HQMMs), which can be…

Machine Learning · Computer Science 2019-03-13 Sandesh Adhikary , Siddarth Srinivasan , Byron Boots

We introduce a novel algorithm for gradient-based optimization of stochastic objective functions. The method may be seen as a variant of SGD with momentum equipped with an adaptive learning rate automatically adjusted by an 'energy'…

Optimization and Control · Mathematics 2022-03-24 Hailiang Liu , Xuping Tian

Optimization drives advances in quantum science and machine learning, yet most generative models aim to mimic data rather than to discover optimal answers to challenging problems. Here we present a variational generative optimization…

Quantum Physics · Physics 2025-08-19 Lingxia Zhang , Xiaodie Lin , Peidong Wang , Kaiyan Yang , Xiao Zeng , Zhaohui Wei , Zizhu Wang

Variational Bayes (VB) is a critical method in machine learning and statistics, underpinning the recent success of Bayesian deep learning. The natural gradient is an essential component of efficient VB estimation, but it is prohibitively…

Quantum Physics · Physics 2022-06-22 Anna Lopatnikova , Minh-Ngoc Tran

Accelerating the convergence of second-order optimization, particularly Newton-type methods, remains a pivotal challenge in algorithmic research. In this paper, we extend previous work on the \textbf{Quadratic Gradient (QG)} and rigorously…

Optimization and Control · Mathematics 2026-04-01 John Chiang

Recent results suggest that quantum computers possess the potential to speed up nonconvex optimization problems. However, a crucial factor for the implementation of quantum optimization algorithms is their robustness against experimental…

Quantum Physics · Physics 2022-12-07 Weiyuan Gong , Chenyi Zhang , Tongyang Li

Accurate quantum tomography is a vital tool in both fundamental and applied quantum science. It is a task that involves processing a noisy measurement record in order to construct a reliable estimate of an unknown quantum state, and is…

Quantum Physics · Physics 2017-01-02 Eliot Bolduc , George Knee , Erik Gauger , Jonathan Leach

Bayesian methods in machine learning, such as Gaussian processes, have great advantages com-pared to other techniques. In particular, they provide estimates of the uncertainty associated with a prediction. Extending the Bayesian approach to…

Quantum Physics · Physics 2019-05-20 Zhikuan Zhao , Alejandro Pozas-Kerstjens , Patrick Rebentrost , Peter Wittek

Global optimization has gained attraction over the past decades, thanks to the development of both theoretical foundations and efficient numerical routines. Among recent advances, Kernel Sum of Squares (KernelSOS) provides a powerful…

Deep kernel learning combines the non-parametric flexibility of kernel methods with the inductive biases of deep learning architectures. We propose a novel deep kernel learning model and stochastic variational inference procedure which…

Machine Learning · Statistics 2016-11-03 Andrew Gordon Wilson , Zhiting Hu , Ruslan Salakhutdinov , Eric P. Xing

Non-convex optimization problems are ubiquitous in machine learning, especially in Deep Learning. While such complex problems can often be successfully optimized in practice by using stochastic gradient descent (SGD), theoretical analysis…

Machine Learning · Computer Science 2022-02-21 Harsh Vardhan , Sebastian U. Stich

Quantum machines are among the most promising technologies expected to provide significant improvements in the following years. However, bridging the gap between real-world applications and their implementation on quantum hardware is still…

The general perception is that kernel methods are not scalable, and neural nets are the methods of choice for nonlinear learning problems. Or have we simply not tried hard enough for kernel methods? Here we propose an approach that scales…

Machine Learning · Computer Science 2015-09-11 Bo Dai , Bo Xie , Niao He , Yingyu Liang , Anant Raj , Maria-Florina Balcan , Le Song

A kernel-based quantum classifier is the most practical and influential quantum machine learning technique for the hyper-linear classification of complex data. We propose a Variational Quantum Approximate Support Vector Machine (VQASVM)…

Quantum Physics · Physics 2023-03-02 Siheon Park , Daniel K. Park , June-Koo Kevin Rhee

GPU kernels have come to the forefront of computing due to their utility in varied fields, from high-performance computing to machine learning. A typical GPU compute kernel is invoked millions, if not billions of times in a typical…

Machine Learning · Computer Science 2024-04-18 Khawir Mahmood , Jehandad Khan , Hammad Afzal

Finding optimal parameter configurations for tunable GPU kernels is a non-trivial exercise for large search spaces, even when automated. This poses an optimization task on a non-convex search space, using an expensive to evaluate function…

Machine Learning · Computer Science 2021-12-01 Floris-Jan Willemsen , Rob van Nieuwpoort , Ben van Werkhoven

Sequence Alignment is the process of aligning biological sequences in order to identify similarities between multiple sequences. In this paper, a Quantum Algorithm for finding the optimal alignment between DNA sequences has been…

Data Structures and Algorithms · Computer Science 2025-09-05 Md. Rabiul Islam Khan , Shadman Shahriar , Shaikh Farhan Rafid