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We present a theoretical study aiming at model fitting for sensory neurons. Conventional neural network training approaches are not applicable to this problem due to lack of continuous data. Although the stimulus can be considered as a…

Neurons and Cognition · Quantitative Biology 2017-09-28 R. Ozgur Doruk , Kechen Zhang

A simple model that replicates the dynamics of spiking and spiking-bursting activity of real biological neurons is proposed. The model is a two-dimensional map which contains one fast and one slow variable. The mechanisms behind generation…

Chaotic Dynamics · Physics 2009-11-07 Nikolai F. Rulkov

Synchronization is a widespread phenomenon in the brain. Despite numerous studies, the specific parameter configurations of the synaptic network structure and learning rules needed to achieve robust and enduring synchronization in neurons…

Neurons and Cognition · Quantitative Biology 2023-08-15 Marius E. Yamakou , Mathieu Desroches , Serafim Rodrigues

Neural-network processing in machine learning applications relies on layer synchronization. This is practiced even in artificial Spiking Neural Networks (SNNs), which are touted as consistent with neurobiology, in spite of processing in the…

Neural and Evolutionary Computing · Computer Science 2025-10-27 Roel Koopman , Amirreza Yousefzadeh , Mahyar Shahsavari , Guangzhi Tang , Manolis Sifalakis

Brain functions require both segregated processing of information in specialized circuits, as well as integration across circuits to perform high-level information processing. One possible way to implement these seemingly opposing demands…

Learning is based on synaptic plasticity, which affects and is driven by neural activity. Because pre- and postsynaptic spiking activity is shaped by randomness, the synaptic weights follow a stochastic process, requiring a probabilistic…

Neurons and Cognition · Quantitative Biology 2026-01-14 Jakob Stubenrauch , Naomi Auer , Richard Kempter , Benjamin Lindner

We present a first-order non-homogeneous Markov model for the interspike-interval density of a continuously stimulated spiking neuron. The model allows the conditional interspike-interval density and the stationary interspike-interval…

Neurons and Cognition · Quantitative Biology 2012-08-15 J. Tapson , C. Jin , A. van Schaik , R. Etienne-Cummings

The highly irregular spiking activity of cortical neurons and behavioral variability suggest that the brain could operate in a fundamentally probabilistic way. Mimicking how the brain implements and learns probabilistic computation could be…

Neural and Evolutionary Computing · Computer Science 2024-04-23 Yang Qi , Zhichao Zhu , Yiming Wei , Lu Cao , Zhigang Wang , Jie Zhang , Wenlian Lu , Jianfeng Feng

We analyze the control of frequency for a synchronized inhibitory neuronal network. The analysis is done for a reduced membrane model with a biophysically-based synaptic influence. We argue that such a reduced model can quantitatively…

Neurons and Cognition · Quantitative Biology 2007-05-23 Carson C. Chow , John A. White , Jason Ritt , Nancy Kopell

Since the first recordings made of evoked action potentials it has become apparent that the responses of individual neurons to ongoing physiologically relevant input, are highly variable. This variability is manifested in non-stationary…

Neurons and Cognition · Quantitative Biology 2010-08-10 Avner Wallach , Danny Eytan , Asaf Gal , Christoph Zrenner , Ron Meir , Shimon Marom

In this article, we study optimal control problems of spiking neurons whose dynamics are described by a phase model. We design minimum-power current stimuli (controls) that lead to targeted spiking times of neurons, where the cases with…

Dynamical Systems · Mathematics 2010-11-18 Isuru Dasanayake , Jr-Shin Li

Conventional digital computation is rapidly approaching physical limits for speed and energy dissipation. Here we fabricate and test a simple neuromorphic circuit that models neuronal somas, axons and synapses with superconducting Josephson…

Neurons and Cognition · Quantitative Biology 2017-03-29 Ken Segall , Matthew LeGro , Steven Kaplan , Oleksiy Svitelskiy , Shreeya Khadka , Patrick Crotty , Daniel Schult

Networks of excitatory and inhibitory neurons display asynchronous irregular (AI) states, where the activities of the two populations are balanced. At the single cell level, it was shown that neurons subject to balanced and noisy synaptic…

Neurons and Cognition · Quantitative Biology 2016-11-29 Zahara Girones , Alain Destexhe

We study the response of a Hodgkin-Huxley neuron stimulated by a periodic sequence of conductance pulses arriving through the synapse in the high frequency regime. In addition to the usual excitation threshold there is a smooth crossover…

Biological Physics · Physics 2010-04-08 L. S. Borkowski

The spatiotemporal stochastic dynamics of the voltage as well as the upcrossing rate are derived for a model neuron comprising a long dendrite with uniformly distributed filtered excitatory and inhibitory synaptic drive. A cascade of…

Neurons and Cognition · Quantitative Biology 2023-04-18 Robert P Gowers , Magnus J E Richardson

Inhibitory neurons play a crucial role in maintaining persistent neuronal activity. Although connected extensively through electrical synapses (gap-junctions), these neurons also exhibit interactions through chemical synapses in certain…

Neurons and Cognition · Quantitative Biology 2021-04-08 R. Janaki , A. S. Vytheeswaran

The quadratic adaptive integrate-and-fire model (Izhikecih 2003, 2007) is recognized as very interesting for its computational efficiency and its ability to reproduce many behaviors observed in cortical neurons. For this reason it is…

Dynamical Systems · Mathematics 2012-11-07 Jonathan Touboul

Background: The roles of neuromodulation in a neural network, such as in a cortical microcolumn, are still incompletely understood. Neuromodulation influences neural processing by presynaptic and postsynaptic regulation of synaptic…

Neurons and Cognition · Quantitative Biology 2019-06-25 Gabriele Scheler

Complex coherent dynamics is present in a wide variety of neural systems. A typical example is the voltage transitions between up and down states observed in cortical areas in the brain. In this work, we study this phenomenon via a…

Neurons and Cognition · Quantitative Biology 2015-05-19 Jorge F. Mejias , Hilbert J. Kappen , Joaquin J. Torres

We propose a formal mathematical model for sparse representations and active dendrites in neocortex. Our model is inspired by recent experimental findings on active dendritic processing and NMDA spikes in pyramidal neurons. These…

Neurons and Cognition · Quantitative Biology 2016-05-16 Subutai Ahmad , Jeff Hawkins