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Alzheimer's Disease Analysis Model (ADAM) is a multi-agent reasoning large language model (LLM) framework designed to integrate and analyze multimodal data, including microbiome profiles, clinical datasets, and external knowledge bases, to…

Artificial Intelligence · Computer Science 2025-08-22 Ziyuan Huang , Vishaldeep Kaur Sekhon , Roozbeh Sadeghian , Maria L. Vaida , Cynthia Jo , Doyle Ward , Vanni Bucci , John P. Haran

Unveiling pathological brain changes associated with Alzheimer's disease (AD) is a challenging task especially that people do not show symptoms of dementia until it is late. Over the past years, neuroimaging techniques paved the way for…

Quantitative Methods · Quantitative Biology 2018-08-07 Mayssa Soussia , Islem Rekik

Parkinson's Disease (PD) is a chronic, degenerative disorder which leads to a range of motor and cognitive symptoms. PD diagnosis is a challenging task since its symptoms are very similar to other diseases such as normal ageing and…

Machine Learning · Computer Science 2021-01-15 Mohamad Alissa

Background: Alzheimers disease is a progressive neurodegenerative disorder and the main cause of dementia in aging. Hippocampus is prone to changes in the early stages of Alzheimers disease. Detection and observation of the hippocampus…

Image and Video Processing · Electrical Eng. & Systems 2021-06-17 Hossein Yousefi-Banaem , Saber Malekzadeh

Alzheimer's disease (AD) is the leading cause of dementia, and its early detection is crucial for effective intervention, yet current diagnostic methods often fall short in sensitivity and specificity. This study aims to detect significant…

Image and Video Processing · Electrical Eng. & Systems 2024-11-01 Milla E. Nielsen , Mads Nielsen , Mostafa Mehdipour Ghazi

Introduction: Machine learning (ML) has been extremely successful in identifying key features from high-dimensional datasets and executing complicated tasks with human expert levels of accuracy or greater. Methods: We summarize and…

Alzheimer's disease is a common cognitive disorder in the elderly. Early and accurate diagnosis of Alzheimer's disease (AD) has a major impact on the progress of research on dementia. At present, researchers have used machine learning…

Sound · Computer Science 2024-02-20 Xiaohui Zhang , Wenjie Fu , Mangui Liang

Increasing effort in brain image analysis has been dedicated to early diagnosis of Alzheimer's disease (AD) based on neuroimaging data. Most existing studies have been focusing on binary classification problems, e.g., distinguishing AD…

Computer Vision and Pattern Recognition · Computer Science 2017-09-14 Hongming Li , Mohamad Habes , Yong Fan

We propose a mesh-based technique to aid in the classification of Alzheimer's disease dementia (ADD) using mesh representations of the cortex and subcortical structures. Deep learning methods for classification tasks that utilize structural…

Image and Video Processing · Electrical Eng. & Systems 2022-03-14 Emanuel A. Azcona , Pierre Besson , Yunan Wu , Arjun Punjabi , Adam Martersteck , Amil Dravid , Todd B. Parrish , S. Kathleen Bandt , Aggelos K. Katsaggelos

Introduction: Alzheimer's disease is a type of dementia in which early diagnosis plays a major rule in the quality of treatment. Among new works in the diagnosis of Alzheimer's disease, there are many of them analyzing the voice stream…

Machine Learning · Computer Science 2019-10-02 S. Soroush Haj Zargarbashi , Bagher Babaali

Alzheimer's disease is the most common cause of dementia, yet difficult to accurately diagnose without the use of invasive techniques, particularly at the beginning of the disease. This work addresses the classification and analysis of…

Computer Vision and Pattern Recognition · Computer Science 2017-12-06 Wellington Pinheiro dos Santos , Ricardo Emmanuel de Souza , Ascendino Flávio Dias e Silva , Plínio Batista dos Santos Filho

Alzheimer's disease (AD), a degenerative brain condition, can benefit from early prediction to slow its progression. As the disease progresses, patients typically undergo brain atrophy. Current prediction methods for Alzheimers disease…

Computer Vision and Pattern Recognition · Computer Science 2025-11-27 Xin Honga , Jie Lin , Minghui Wang

Alzheimer's disease (AD) is the fifth-leading cause of death among Americans aged 65 and older. Screening and early detection of AD and related dementias (ADRD) are critical for timely intervention and for identifying clinical trial…

Artificial Intelligence · Computer Science 2024-05-29 Jiankun Wang , Sumyeong Ahn , Taykhoom Dalal , Xiaodan Zhang , Weishen Pan , Qiannan Zhang , Bin Chen , Hiroko H. Dodge , Fei Wang , Jiayu Zhou

For effective treatment of Alzheimer disease (AD), it is important to identify subjects who are most likely to exhibit rapid cognitive decline. Herein, we developed a novel framework based on a deep convolutional neural network which can…

Computer Vision and Pattern Recognition · Computer Science 2017-04-21 Hongyoon Choi , Kyong Hwan Jin

Early detection of Alzheimer's Disease (AD) and its prodromal state, Mild Cognitive Impairment (MCI), is crucial for providing suitable treatment and preventing the disease from progressing. It can also aid researchers and clinicians to…

Image and Video Processing · Electrical Eng. & Systems 2023-05-02 Arunima Jaiswal , Ananya Sadana

Alzheimer's disease is the most common cause of dementia, yet hard to diagnose precisely without invasive techniques, particularly at the onset of the disease. This work approaches image analysis and classification of synthetic…

Image and Video Processing · Electrical Eng. & Systems 2017-12-05 Wellington Pinheiro dos Santos , Ricardo Emmanuel de Souza , Plínio B. dos Santos Filho

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that progressively destroys memory and other cognitive domains of the brain. While effective therapeutic management of AD is still in development, it seems reasonable to…

Image and Video Processing · Electrical Eng. & Systems 2020-11-10 Oleg Michailovich , Rinat Mukhometzianov

Alzheimer's disease (AD) constitutes a neurodegenerative disease with serious consequences to peoples' everyday lives, if it is not diagnosed early since there is no available cure. Alzheimer's is the most common cause of dementia, which…

Computation and Language · Computer Science 2023-01-18 Loukas Ilias , Dimitris Askounis , John Psarras

In order to find effective treatments for Alzheimer's disease (AD), we need to identify subjects at risk of AD as early as possible. To this end, recently developed disease progression models can be used to perform early diagnosis, as well…

Quantitative Methods · Quantitative Biology 2020-03-11 Razvan V. Marinescu

Alzheimer's disease (AD) is an irreversible and progressive brain disease that can be stopped or slowed down with medical treatment. Language changes serve as a sign that a patient's cognitive functions have been impacted, potentially…

Computation and Language · Computer Science 2018-04-19 Sweta Karlekar , Tong Niu , Mohit Bansal