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Background: Patients with neovascular age-related macular degeneration (AMD) can avoid vision loss via certain therapy. However, methods to predict the progression to neovascular age-related macular degeneration (nvAMD) are lacking.…

Computer Vision and Pattern Recognition · Computer Science 2019-04-12 Boris Babenko , Siva Balasubramanian , Katy E. Blumer , Greg S. Corrado , Lily Peng , Dale R. Webster , Naama Hammel , Avinash V. Varadarajan

We propose a hybrid sequential deep learning model to predict the risk of AMD progression in non-exudative AMD eyes at multiple timepoints, starting from short-term progression (3-months) up to long-term progression (21-months). Proposed…

Quantitative Methods · Quantitative Biology 2019-03-01 Imon Banerjee , Luis de Sisternes , Joelle Hallak , Theodore Leng , Aaron Osborne , Mary Durbin , Daniel Rubin

Predicting future disease progression risk from medical images is challenging due to patient heterogeneity, and subtle or unknown imaging biomarkers. Moreover, deep learning (DL) methods for survival analysis are susceptible to image domain…

Age-related Macular Degeneration (AMD) is a prevalent eye condition affecting visual acuity. Anti-vascular endothelial growth factor (anti-VEGF) treatments have been effective in slowing the progression of neovascular AMD, with better…

This paper tackles automated categorization of Age-related Macular Degeneration (AMD), a common macular disease among people over 50. Previous research efforts mainly focus on AMD categorization with a single-modal input, let it be a color…

Computer Vision and Pattern Recognition · Computer Science 2022-05-05 Weisen Wang , Xirong Li , Zhiyan Xu , Weihong Yu , Jianchun Zhao , Dayong Ding , Youxin Chen

Self-supervised learning (SSL) has emerged as a powerful technique for improving the efficiency and effectiveness of deep learning models. Contrastive methods are a prominent family of SSL that extract similar representations of two…

By 2040, age-related macular degeneration (AMD) will affect approximately 288 million people worldwide. Identifying individuals at high risk of progression to late AMD, the sight-threatening stage, is critical for clinical actions,…

Image and Video Processing · Electrical Eng. & Systems 2020-07-21 Yifan Peng , Tiarnan D. Keenan , Qingyu Chen , Elvira Agrón , Alexis Allot , Wai T. Wong , Emily Y. Chew , Zhiyong Lu

We propose a method to predict severity of age related macular degeneration (AMD) from input optical coherence tomography (OCT) images. Although there is no standard clinical severity scale for AMD, we leverage deep learning (DL) based…

Computer Vision and Pattern Recognition · Computer Science 2019-07-09 Dwarikanath Mahapatra

Pre-training strategies based on self-supervised learning (SSL) have proven to be effective pretext tasks for many downstream tasks in computer vision. Due to the significant disparity between medical and natural images, the application of…

Vision transformers, with their ability to more efficiently model long-range context, have demonstrated impressive accuracy gains in several computer vision and medical image analysis tasks including segmentation. However, such methods need…

Image and Video Processing · Electrical Eng. & Systems 2022-09-27 Jue Jiang , Neelam Tyagi , Kathryn Tringale , Christopher Crane , Harini Veeraraghavan

Age-related macular degeneration (AMD) is the most common cause of blindness in developed countries, especially in people over 60 years of age. The workload of specialists and the healthcare system in this field has increased in recent…

Image and Video Processing · Electrical Eng. & Systems 2022-02-07 Saman Sotoudeh-Paima , Ata Jodeiri , Fedra Hajizadeh , Hamid Soltanian-Zadeh

Deep learning has enabled breakthroughs in automated diagnosis from medical imaging, with many successful applications in ophthalmology. However, standard medical image classification approaches only assess disease presence at the time of…

Computer Vision and Pattern Recognition · Computer Science 2024-07-31 Gregory Holste , Mingquan Lin , Ruiwen Zhou , Fei Wang , Lei Liu , Qi Yan , Sarah H. Van Tassel , Kyle Kovacs , Emily Y. Chew , Zhiyong Lu , Zhangyang Wang , Yifan Peng

Longitudinal imaging is capable of capturing the static ana\-to\-mi\-cal structures and the dynamic changes of the morphology resulting from aging or disease progression. Self-supervised learning allows to learn new representation from…

Image and Video Processing · Electrical Eng. & Systems 2019-10-25 Antoine Rivail , Ursula Schmidt-Erfurth , Wolf-Dieter Vogl , Sebastian M. Waldstein , Sophie Riedl , Christoph Grechenig , Zhichao Wu , Hrvoje Bogunović

Diseases are currently managed by grading systems, where patients are stratified by grading systems into stages that indicate patient risk and guide clinical management. However, these broad categories typically lack prognostic value, and…

Self-Supervised Learning (SSL) has emerged as a powerful paradigm to mitigate the reliance on large, annotated datasets, a common bottleneck in medical image analysis. However, standard SSL methods, which rely on simple geometric and color…

Computer Vision and Pattern Recognition · Computer Science 2026-05-27 Joao Batista Florindo

Contrastive, self-supervised learning (SSL) is used to train a model that predicts cancer type from miRNA, mRNA or RPPA expression data. This model, a pretrained FT-Transformer, is shown to outperform XGBoost and CatBoost, standard…

Machine Learning · Computer Science 2023-11-17 Christian John Hurry , Emma Slade

Longitudinal imaging is able to capture both static anatomical structures and dynamic changes in disease progression towards earlier and better patient-specific pathology management. However, conventional approaches for detecting diabetic…

Computer Vision and Pattern Recognition · Computer Science 2024-03-26 Rachid Zeghlache , Pierre-Henri Conze , Mostafa El Habib Daho , Ramin Tadayoni , Pascal Massin , Béatrice Cochener , Gwenolé Quellec , Mathieu Lamard

Self-supervised learning (SSL) methods such as masked language modeling have shown massive performance gains by pretraining transformer models for a variety of natural language processing tasks. The follow-up research adapted similar…

Computer Vision and Pattern Recognition · Computer Science 2022-05-12 Gokul Karthik Kumar , Sahal Shaji Mullappilly , Abhishek Singh Gehlot

Age-related Macular Degeneration (AMD) is a leading cause of blindness. Although the Age-Related Eye Disease Study group previously developed a 9-step AMD severity scale for manual classification of AMD severity from color fundus images,…

Machine Learning · Computer Science 2018-12-04 Qingyu Chen , Yifan Peng , Tiarnan Keenan , Shazia Dharssi , Elvira Agron , Wai T. Wong , Emily Y. Chew , Zhiyong Lu

Self-supervised learning (SSL) has enabled Vision Transformers (ViTs) to learn robust representations from large-scale natural image datasets, enhancing their generalization across domains. In retinal imaging, foundation models pretrained…

Image and Video Processing · Electrical Eng. & Systems 2025-05-23 Benjamin A. Cohen , Jonathan Fhima , Meishar Meisel , Baskin Meital , Luis Filipe Nakayama , Eran Berkowitz , Joachim A. Behar
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