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Recently, persistent homology has had tremendous success in biomolecular data analysis. It works by examining the topological relationship or connectivity of a group of atoms in a molecule at a variety of scales, then rendering a family of…

Biomolecules · Quantitative Biology 2019-03-27 David Bramer , Guo-Wei Wei

In this study, we present a novel molecular fingerprint generation method based on multiparameter persistent homology. This approach reveals the latent structures and relationships within molecular geometry, and detects topological features…

Biomolecules · Quantitative Biology 2023-11-21 Andac Demir , Bulent Kiziltan

The protein folding problem must ultimately be solved on all length scales from the atomic up through a hierarchy of complicated structures. By analyzing the stability of the folding process using physics and mathematics, this paper shows…

Biological Physics · Physics 2015-05-28 Walter Simmons , Joel L. Weiner

Art is a deeply personal and expressive medium, where each artist brings their own style, technique, and cultural background into their work. Traditionally, identifying artistic styles has been the job of art historians or critics, relying…

Computer Vision and Pattern Recognition · Computer Science 2025-11-24 Reetikaa Reddy Munnangi , Barbara Giunti

The persistent homology transform (PHT) represents a shape with a multiset of persistence diagrams parameterized by the sphere of directions in the ambient space. In this work, we describe a finite set of diagrams that discretize the PHT…

Computational Geometry · Computer Science 2026-05-26 Brittany Terese Fasy , Samuel Micka , David L. Millman , Anna Schenfisch , Lucia Williams

High-accuracy prediction of the physical properties of amorphous materials is challenging in condensed-matter physics. A promising method to achieve this is machine-learning potentials, which is an alternative to computationally demanding…

Machine Learning · Computer Science 2023-05-23 Emi Minamitani , Ippei Obayashi , Koji Shimizu , Satoshi Watanabe

We propose a unified framework based on persistent homology (PH) to characterize both local and global structures in disordered systems. It can simultaneously generate local and global descriptors using the same algorithm and data…

Disordered Systems and Neural Networks · Physics 2025-11-03 An Wang , Li Zou

The Persistent Homology Transform (PHT) summarizes a shape in $\mathbb{R}^m$ by collecting persistence diagrams obtained from linear height filtrations in all directions on $\mathbb{S}^{m-1}$. It enjoys strong theoretical guarantees,…

Computational Geometry · Computer Science 2026-04-10 Michael Kerber , Elena Xinyi Wang

High-quality training data is the foundation of machine learning and artificial intelligence, shaping how models learn and perform. Although much is known about what types of data are effective for training, the impact of the data's…

Machine Learning · Computer Science 2025-10-21 Yang Ba , Mohammad Sadeq Abolhasani , Rong Pan

Machine learning model development in chemistry and materials science often grapples with the challenge of small scale, unbalanced labelled datasets, a common limitation in scientific experiments. These dataset imbalances can precipitate…

Chemical Physics · Physics 2026-05-19 Yuze Liu , Xi Yu

Persistent homology is a relatively new tool often used for \emph{qualitative} analysis of intrinsic topological features in images and data originated from scientific and engineering applications. In this paper, we report novel…

Biomolecules · Quantitative Biology 2014-12-09 Kelin Xia , Xin Feng , Yiying Tong , Guo Wei We

Prediction and discovery of new materials with desired properties are at the forefront of quantum science and technology research. A major bottleneck in this field is the computational resources and time complexity related to finding new…

In this study, we present a novel computational method for generating molecular fingerprints using multiparameter persistent homology (MPPH). This technique holds considerable significance for drug discovery and materials science, where…

Machine Learning · Computer Science 2023-12-14 Andac Demir , Francis Prael , Bulent Kiziltan

In this paper, we introduce a novel framework for memory-efficient and privacy-preserving continual learning in 3D object classification. Unlike conventional memory-based approaches in continual learning that require storing numerous…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Hossein Resani , Behrooz Nasihatkon

Tumor segmentation in whole-slide images of histology slides is an important step towards computer-assisted diagnosis. In this work, we propose a tumor segmentation framework based on the novel concept of persistent homology profiles…

Computer Vision and Pattern Recognition · Computer Science 2018-05-11 Talha Qaiser , Yee-Wah Tsang , Daiki Taniyama , Naoya Sakamoto , Kazuaki Nakane , David Epstein , Nasir Rajpoot

A topological shape analysis is proposed and utilized to learn concepts that reflect shape commonalities. Our approach is two-fold: i) a spatial topology analysis of point cloud segment constellations within objects. Therein constellations…

Computer Vision and Pattern Recognition · Computer Science 2018-11-22 Christian A. Mueller , Andreas Birk

Persistent homology (PH) is an approach to topological data analysis (TDA) that computes multi-scale topologically invariant properties of high-dimensional data that are robust to noise. While PH has revealed useful patterns across various…

Machine Learning · Computer Science 2021-03-23 Manu Aggarwal , Vipul Periwal

Biomolecular structure comparison not only reveals evolutionary relationships, but also sheds light on biological functional properties. However, traditional definitions of structure or sequence similarity always involve superposition or…

Quantitative Methods · Quantitative Biology 2017-07-13 Kelin Xia

Persistent homology (PH) is a popular tool for topological data analysis that has found applications across diverse areas of research. It provides a rigorous method to compute robust topological features in discrete experimental…

Machine Learning · Computer Science 2023-07-19 Manu Aggarwal , Vipul Periwal

Hyperuniformity, the suppression of density fluctuations at large length scales, is observed across a wide variety of domains, from cosmology to condensed matter and biological systems. Although the standard definition of hyperuniformity…

Statistical Mechanics · Physics 2024-05-07 Marco Salvalaglio , Dominic J. Skinner , Jörn Dunkel , Axel Voigt