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The accurate diagnosis and molecular profiling of colorectal cancers are critical for planning the best treatment options for patients. Microsatellite instability (MSI) or mismatch repair (MMR) status plays a vital role in appropriate…

Quantitative Methods · Quantitative Biology 2022-04-27 Ruqayya Awan , Mohammed Nimir , Shan E Ahmed Raza , Mohsin Bilal , Johannes Lotz , David Snead , Andrew Robinson , Nasir Rajpoot

Microsatellite instability-high (MSI-H) is a tumor agnostic biomarker for immune checkpoint inhibitor therapy. However, MSI status is not routinely tested in prostate cancer, in part due to low prevalence and assay cost. As such, prediction…

Microsatellite instability (MSI) is a tumor phenotype whose diagnosis largely impacts patient care in colorectal cancers (CRC), and is associated with response to immunotherapy in all solid tumors. Deep learning models detecting MSI tumors…

Image and Video Processing · Electrical Eng. & Systems 2022-03-23 Charlie Saillard , Olivier Dehaene , Tanguy Marchand , Olivier Moindrot , Aurélie Kamoun , Benoit Schmauch , Simon Jegou

In this work, a modified ResNet model is proposed for the classification of Microsatellite instability(MSI) and Microsatellite stability(MSS) of gastrointestinal cancer. The performance of this model is analyzed and compared with existing…

Image and Video Processing · Electrical Eng. & Systems 2022-02-07 CH Sai Venkatesh , Caleb Meriga , M. G. V. L Geethika , T Lakshmi Gayatri , V. B. K. L Aruna

Microsatellite instability (MSI) is associated with several tumor types and its status has become increasingly vital in guiding patient treatment decisions. However, in clinical practice, distinguishing MSI from its counterpart is…

Machine Learning · Statistics 2020-10-08 Jin Zhu , Wangwei Wu , Yuting Zhang , Shiyun Lin , Yukang Jiang , Ruixian Liu , Xueqin Wang

The prediction of microsatellite instability (MSI) and microsatellite stability (MSS) is essential in predicting both the treatment response and prognosis of gastrointestinal cancer. In clinical practice, a universal MSI testing is…

Image and Video Processing · Electrical Eng. & Systems 2022-01-14 Kaifeng Pang , Zuhayr Asad , Shilin Zhao , Yuankai Huo

Assessing microsatellite stability status of a patient's colorectal cancer is crucial in personalizing treatment regime. Recently, convolutional-neural-networks (CNN) combined with transfer-learning approaches were proposed to circumvent…

Computer Vision and Pattern Recognition · Computer Science 2022-08-23 Daniel Shats , Hadar Hezi , Guy Shani , Yosef E. Maruvka , Moti Freiman

Based on global genomic status, the cancer tumor is classified as Microsatellite Instable (MSI) and Microsatellite Stable (MSS). Immunotherapy is used to diagnose MSI, whereas radiation and chemotherapy are used for MSS. Therefore, it is…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Sai Venkatesh Chilukoti , Imran Hossen Md , Liqun Shan , Vijay Srinivas Tida , Xiali Hei

We present a system for the prediction of microsatellite instability (MSI) from H&E images of colorectal cancer using deep learning (DL) techniques customized for tissue microarrays (TMAs). The system incorporates an end-to-end image…

Computer Vision and Pattern Recognition · Computer Science 2021-10-29 Aurelia Bustos , Artemio Payá , Andres Torrubia , Rodrigo Jover , Xavier Llor , Xavier Bessa , Antoni Castells , Cristina Alenda

Mass spectrometry imaging (MSI) as an analytical tool for bio-molecular and bio-medical research targets, accurate compound localization and identification. In terms of dedicated instrumentation, this translates into the demand for more…

Instrumentation and Detectors · Physics 2013-05-24 Julia H. Jungmann , Ron M. A. Heeren

Colorectal cancer (CRC) micro-satellite instability (MSI) prediction on histopathology images is a challenging weakly supervised learning task that involves multi-instance learning on gigapixel images. To date, radiology images have proven…

Computer Vision and Pattern Recognition · Computer Science 2024-01-17 Quan Liu , Jiawen Yao , Lisha Yao , Xin Chen , Jingren Zhou , Le Lu , Ling Zhang , Zaiyi Liu , Yuankai Huo

Artificial intelligence (AI) models have been developed for predicting clinically relevant biomarkers, including microsatellite instability (MSI), for colorectal cancers (CRC). However, the current deep-learning networks are data-hungry and…

Quantitative Methods · Quantitative Biology 2024-12-24 Bangwei Guo , Xingyu Li , Jitendra Jonnagaddala , Hong Zhang , Xu Steven Xu

Considering the profound transformation affecting pathology practice, we aimed to develop a scalable artificial intelligence (AI) system to diagnose colorectal cancer from whole-slide images (WSI). For this, we propose a deep learning (DL)…

Mass spectrometry imaging (MSI) enables label-free visualization of molecular distributions across tissue samples but generates large and complex datasets that require effective peak picking to reduce data size while preserving meaningful…

Computer Vision and Pattern Recognition · Computer Science 2026-03-12 Philipp Weigand , Nikolas Ebert , Shad A. Mohammed , Denis Abu Sammour , Carsten Hopf , Oliver Wasenmüller

With the recent development of technology, wireless sensor networks (WSN) are becoming an important part of many applications. Knowing the exact location of each sensor in the network is very important issue. Therefore, the localization…

Networking and Internet Architecture · Computer Science 2016-06-27 Biljana Risteska Stojkoska , Vesna Kirandziska

Multispectral imaging (MSI) plays a critical role in material classification, environmental monitoring, and remote sensing. However, MSI sensors typically have wavelength-dependent resolution, which limits downstream analysis. MSI…

Image and Video Processing · Electrical Eng. & Systems 2026-03-10 Haley Duba-Sullivan , Emma J. Reid , Sophie Voisin , Charles A. Bouman , Gregery T. Buzzard

Bi-parametric magnetic resonance imaging (bpMRI) has become a pivotal modality in the detection and diagnosis of clinically significant prostate cancer (csPCa). Developing AI-based systems to identify csPCa using bpMRI can transform PCa…

Image and Video Processing · Electrical Eng. & Systems 2024-09-24 Yuan Yuan , Euijoon Ahn , Dagan Feng , Mohamad Khadra , Jinman Kim

Recently, hyperspectral imaging (HSI) has attracted increasing research attention, especially for the ones based on a coded aperture snapshot spectral imaging (CASSI) system. Existing deep HSI reconstruction models are generally trained on…

Image and Video Processing · Electrical Eng. & Systems 2022-09-27 Jiamian Wang , Yulun Zhang , Xin Yuan , Ziyi Meng , Zhiqiang Tao

Isochronous mass spectrometry (IMS) in storage rings is a successful technique for accurate mass measurements of short-lived nuclides with relative precision of about $10^{-5}-10^{-7}$. Instabilities of the magnetic fields in storage rings…

The Laser Interferometer Space Antenna (LISA) is expected to simultaneously detect many thousands of low frequency gravitational wave signals. This presents a data analysis challenge that is very different to the one encountered in ground…

General Relativity and Quantum Cosmology · Physics 2009-11-11 Neil J. Cornish , Jeff Crowder
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