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In this paper, we highlight three issues that limit performance of machine learning on biomedical images, and tackle them through 3 case studies: 1) Interactive Machine Learning (IML): we show how IML can drastically improve exploration…

Computer Vision and Pattern Recognition · Computer Science 2019-02-18 Naimul Mefraz Khan , Nabila Abraham , Ling Guan

Current state-of-the-art instance segmentation methods are not suited for real-time applications like autonomous driving, which require fast execution times at high accuracy. Although the currently dominant proposal-based methods have high…

Computer Vision and Pattern Recognition · Computer Science 2019-08-05 Davy Neven , Bert De Brabandere , Marc Proesmans , Luc Van Gool

Brain lesions, including stroke and tumours, have a high degree of variability in terms of location, size, intensity and form, making automatic segmentation difficult. We propose an improvement to existing segmentation methods by exploiting…

Image and Video Processing · Electrical Eng. & Systems 2019-07-22 Kevin Raina , Uladzimir Yahorau , Tanya Schmah

Imaging mass cytometry (IMC) is a relatively new technique for imaging biological tissue at subcellular resolution. In recent years, learning-based segmentation methods have enabled precise quantification of cell type and morphology, but…

Image and Video Processing · Electrical Eng. & Systems 2025-06-06 Kimberley M. Bird , Xujiong Ye , Alan M. Race , James M. Brown

Albeit the Dice loss is one of the dominant loss functions in medical image segmentation, most research omits a closer look at its derivative, i.e. the real motor of the optimization when using gradient descent. In this paper, we highlight…

Computer Vision and Pattern Recognition · Computer Science 2022-11-10 Sofie Tilborghs , Jeroen Bertels , David Robben , Dirk Vandermeulen , Frederik Maes

Medical image segmentation aims to delineate the anatomical or pathological structures of interest, playing a crucial role in clinical diagnosis. A substantial amount of high-quality annotated data is crucial for constructing high-precision…

Computer Vision and Pattern Recognition · Computer Science 2024-02-28 Zhongnuo Yan , Tong Han , Yuhao Huang , Lian Liu , Han Zhou , Jiongquan Chen , Wenlong Shi , Yan Cao , Xin Yang , Dong Ni

Deep learning methods have been shown to be effective for the automatic segmentation of structures and pathologies in medical imaging. However, they require large annotated datasets, whose manual segmentation is a tedious and time-consuming…

Image and Video Processing · Electrical Eng. & Systems 2022-09-27 Bella Specktor Fadida , Daphna Link Sourani , Liat Ben Sira Elka Miller , Dafna Ben Bashat , Leo Joskowicz

Segmenting curvilinear structures in medical images is essential for analyzing morphological patterns in clinical applications. Integrating topological properties, such as connectivity, improves segmentation accuracy and consistency.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Zhuangzhi Gao , Feixiang Zhou , He Zhao , Xiuju Chen , Xiaoxin Li , Qinkai Yu , Yitian Zhao , Alena Shantsila , Gregory Y. H. Lip , Eduard Shantsila , Yalin Zheng

Instance segmentation aims to delineate each individual object of interest in an image. State-of-the-art approaches achieve this goal by either partitioning semantic segmentations or refining coarse representations of detected objects. In…

Computer Vision and Pattern Recognition · Computer Science 2022-10-10 Long Chen , Yuli Wu , Dorit Merhof

We present a weakly supervised deep learning method to perform instance segmentation of cells present in microscopy images. Annotation of biomedical images in the lab can be scarce, incomplete, and inaccurate. This is of concern when…

Computer Vision and Pattern Recognition · Computer Science 2019-08-28 Fidel A. Guerrero-Peña , Pedro D. Marrero Fernandez , Tsang Ing Ren , Alexandre Cunha

Magnetic resonance imaging (MRI) is a central modality for stroke imaging. It is used upon patient admission to make treatment decisions such as selecting patients for intravenous thrombolysis or endovascular therapy. MRI is later used in…

Medical image segmentation remains challenging due to the vast diversity of anatomical structures, imaging modalities, and segmentation tasks. While deep learning has made significant advances, current approaches struggle to generalize as…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Yunhe Gao , Di Liu , Zhuowei Li , Yunsheng Li , Dongdong Chen , Mu Zhou , Dimitris N. Metaxas

Loss functions play a crucial role in deep metric learning thus a variety of them have been proposed. Some supervise the learning process by pairwise or tripletwise similarity constraints while others take advantage of structured similarity…

Machine Learning · Computer Science 2019-11-25 Xinshao Wang , Elyor Kodirov , Yang Hua , Neil Robertson

Spatial Independent Components Analysis (ICA) is increasingly used in the context of functional Magnetic Resonance Imaging (fMRI) to study cognition and brain pathologies. Salient features present in some of the extracted Independent…

Rapid infarct assessment on non-contrast CT (NCCT) is essential for acute ischemic stroke management. Most deep learning methods perform pixel-wise segmentation without modeling the structured anatomical reasoning underlying ASPECTS…

Image and Video Processing · Electrical Eng. & Systems 2026-03-02 Hiba Azeem , Behraj Khan , Tahir Qasim Syed

Annotating medical images demands significant time and expertise, often requiring pathologists to invest hundreds of hours in labeling mammary epithelial nuclei datasets. We address this critical challenge by achieving 95.5% Dice score…

Artificial Intelligence · Computer Science 2025-12-03 Varun Kumar Dasoju , Qingsu Cheng , Zeyun Yu

Stroke is the second leading cause of mortality worldwide. Immediate attention and diagnosis play a crucial role regarding patient prognosis. The key to diagnosis consists in localizing and delineating brain lesions. Standard stroke…

Image and Video Processing · Electrical Eng. & Systems 2024-09-05 Santiago Gómez , Daniel Mantilla , Gustavo Garzón , Edgar Rangel , Andrés Ortiz , Franklin Sierra-Jerez , Fabio Martínez

Stroke is among the top three causes of death worldwide, and accurate identification of ischemic stroke lesion boundaries from imaging is critical for diagnosis and treatment. The main imaging modalities used include magnetic resonance…

Image and Video Processing · Electrical Eng. & Systems 2025-08-25 Juampablo E. Heras Rivera , Hitender Oswal , Tianyi Ren , Yutong Pan , William Henry , Caitlin M. Neher , Mehmet Kurt

There are many clinical contexts which require accurate detection and segmentation of all focal pathologies (e.g. lesions, tumours) in patient images. In cases where there are a mix of small and large lesions, standard binary cross entropy…

Image and Video Processing · Electrical Eng. & Systems 2022-05-19 Brennan Nichyporuk , Justin Szeto , Douglas L. Arnold , Tal Arbel

In response to the growing importance of geospatial data, its analysis including semantic segmentation becomes an increasingly popular task in computer vision today. Convolutional neural networks are powerful visual models that yield…

Computer Vision and Pattern Recognition · Computer Science 2019-05-21 Alexey Bokhovkin , Evgeny Burnaev