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Digital pathology has become a standard in the pathology workflow due to its many benefits. These include the level of detail of the whole slide images generated and the potential immediate sharing of cases between hospitals. Recent…

Human-Computer Interaction · Computer Science 2023-07-18 Cristian Camilo Pulgarín-Ospina , Rocío del Amor , Adrián Colomera , Julio Silva-Rodríguez , Valery Naranjo

The development of computational pathology lies in the consensus that pathological characteristics of tumors are significant guidance for cancer diagnostics. Most existing research focuses on the inner-contextual information within each WSI…

Computer Vision and Pattern Recognition · Computer Science 2024-10-15 Jun Shi , Tong Shu , Zhiguo Jiang , Wei Wang , Haibo Wu , Yushan Zheng

Histopathological assessments, including surgical resection and core needle biopsy, are the standard procedures in the diagnosis of the prostate cancer. Current interpretation of the histopathology images includes the determination of the…

Computer Vision and Pattern Recognition · Computer Science 2017-05-12 Naiyun Zhou , Andrey Fedorov , Fiona Fennessy , Ron Kikinis , Yi Gao

The emergence of foundation models in computational pathology has transformed histopathological image analysis, with whole slide imaging (WSI) diagnosis being a core application. Traditionally, weakly supervised fine-tuning via multiple…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Jiawen Li , Jiali Hu , Qiehe Sun , Renao Yan , Minxi Ouyang , Tian Guan , Anjia Han , Chao He , Yonghong He

Digital whole slides images contain an enormous amount of information providing a strong motivation for the development of automated image analysis tools. Particularly deep neural networks show high potential with respect to various tasks…

Computer Vision and Pattern Recognition · Computer Science 2023-12-07 Michael Gadermayr , Maximilian Tschuchnig

Recent years witnessed remarkable progress in computational histopathology, largely fueled by deep learning. This brought the clinical adoption of deep learning-based tools within reach, promising significant benefits to healthcare,…

Image and Video Processing · Electrical Eng. & Systems 2024-10-29 Ahmad Obeid , Said Boumaraf , Anabia Sohail , Taimur Hassan , Sajid Javed , Jorge Dias , Mohammed Bennamoun , Naoufel Werghi

Deep convolutional neural networks (CNNs) are the current state-of-the-art for digital analysis of histopathological images. The large size of whole-slide microscopy images (WSIs) requires advanced memory handling to read, display and…

Machine Learning · Computer Science 2020-11-13 André Pedersen , Marit Valla , Anna M. Bofin , Javier Pérez de Frutos , Ingerid Reinertsen , Erik Smistad

Poor performance of quantitative analysis in histopathological Whole Slide Images (WSI) has been a significant obstacle in clinical practice. Annotating large-scale WSIs manually is a demanding and time-consuming task, unlikely to yield the…

Computer Vision and Pattern Recognition · Computer Science 2023-08-08 Sarah Cechnicka , James Ball , Hadrien Reynaud , Callum Arthurs , Candice Roufosse , Bernhard Kainz

Whole Slide Images (WSIs) play a crucial role in accurate cancer diagnosis and prognosis, as they provide tissue details at the cellular level. However, the rapid growth of computational tasks involving WSIs poses significant challenges.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-30 Doanh C. Bui , Hoai Luan Pham , Vu Trung Duong Le , Tuan Hai Vu , Van Duy Tran , Khang Nguyen , Yasuhiko Nakashima

Microscopic interpretation of histopathology images underlies many important diagnostic and treatment decisions. While advances in vision-language modeling raise new opportunities for analysis of such images, the gigapixel-scale size of…

In recent years, the use of deep learning (DL) methods, including convolutional neural networks (CNNs) and vision transformers (ViTs), has significantly advanced computational pathology, enhancing both diagnostic accuracy and efficiency.…

Conventional histopathology has long been essential for disease diagnosis, relying on visual inspection of tissue sections. Immunohistochemistry aids in detecting specific biomarkers but is limited by its single-marker approach, restricting…

Pathology deals with the practice of discovering the reasons for disease by analyzing the body samples. The most used way in this field, is to use histology which is basically studying and viewing microscopic structures of cell and tissues.…

Image and Video Processing · Electrical Eng. & Systems 2021-11-08 Virender Ranga , Shivam Gupta , Priyansh Agrawal , Jyoti Meena

Pathology, the microscopic examination of diseased tissue, is critical for diagnosing various medical conditions, particularly cancers. Traditional methods are labor-intensive and prone to human error. Digital pathology, which converts…

Image and Video Processing · Electrical Eng. & Systems 2024-08-21 Dmitry Nechaev , Alexey Pchelnikov , Ekaterina Ivanova

Histopathological characterization of colorectal polyps is an important principle for determining the risk of colorectal cancer and future rates of surveillance for patients. This characterization is time-intensive, requires years of…

Computer Vision and Pattern Recognition · Computer Science 2017-04-14 Bruno Korbar , Andrea M. Olofson , Allen P. Miraflor , Katherine M. Nicka , Matthew A. Suriawinata , Lorenzo Torresani , Arief A. Suriawinata , Saeed Hassanpour

Tissue segmentation is an important pre-requisite for efficient and accurate diagnostics in digital pathology. However, it is well known that whole-slide scanners can fail in detecting all tissue regions, for example due to the tissue type,…

Computer Vision and Pattern Recognition · Computer Science 2017-04-04 Péter Bándi , Rob van de Loo , Milad Intezar , Daan Geijs , Francesco Ciompi , Bram van Ginneken , Jeroen van der Laak , Geert Litjens

State-of-the-art deep learning systems such as TensorFlow and PyTorch tightly couple the model with the underlying hardware. This coupling requires the user to modify application logic in order to run the same job across a different set of…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-05-13 Andrew Or , Haoyu Zhang , Michael J. Freedman

Artificial intelligence (AI) has transformed digital pathology by enabling biomarker prediction from high-resolution whole-slide images (WSIs). However, current methods are computationally inefficient, processing thousands of redundant…

Deep learning methods are widely used for medical applications to assist medical doctors in their daily routines. While performances reach expert's level, interpretability (highlight how and what a trained model learned and why it makes a…

Computer Vision and Pattern Recognition · Computer Science 2020-09-30 Antoine Pirovano , Hippolyte Heuberger , Sylvain Berlemont , Saïd Ladjal , Isabelle Bloch

Histopathology plays a pivotal role in medical diagnostics. In contrast to preparing permanent sections for histopathology, a time-consuming process, preparing frozen sections is significantly faster and can be performed during surgery,…

Image and Video Processing · Electrical Eng. & Systems 2023-10-18 Elad Yoshai , Gil Goldinger , Miki Haifler , Natan T. Shaked