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Previous foundation models for fundus images were pre-trained with limited disease categories and knowledge base. Here we introduce a knowledge-rich vision-language model (RetiZero) that leverages knowledge from more than 400 fundus…

Classification algorithms have been widely adopted to detect anomalies for various systems, e.g., IoT, cloud and face recognition, under the common assumption that the data source is clean, i.e., features and labels are correctly set.…

Machine Learning · Computer Science 2021-03-22 Zilong Zhao , Robert Birke , Rui Han , Bogdan Robu , Sara Bouchenak , Sonia Ben Mokhtar , Lydia Y. Chen

The application of supervised models to clinical screening tasks is challenging due to the need for annotated data for each considered pathology. Unsupervised Anomaly Detection (UAD) is an alternative approach that aims to identify any…

Image and Video Processing · Electrical Eng. & Systems 2025-01-24 Finn Behrendt , Debayan Bhattacharya , Robin Mieling , Lennart Maack , Julia Krüger , Roland Opfer , Alexander Schlaefer

Automatic clinical diagnosis of retinal diseases has emerged as a promising approach to facilitate discovery in areas with limited access to specialists. Based on the fact that fundus structure and vascular disorders are the main…

Computer Vision and Pattern Recognition · Computer Science 2018-11-05 C. -H. Huck Yang , Fangyu Liu , Jia-Hong Huang , Meng Tian , Hiromasa Morikawa , I-Hung Lin , Yi-Chieh Liu , Hao-Hsiang Yang , Jesper Tegner

Existing multi-modal learning methods on fundus and OCT images mostly require both modalities to be available and strictly paired for training and testing, which appears less practical in clinical scenarios. To expand the scope of clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Lehan Wang , Chongchong Qi , Chubin Ou , Lin An , Mei Jin , Xiangbin Kong , Xiaomeng Li

We introduce a novel framework for AI-generated image detection through epistemic uncertainty, aiming to address critical security concerns in the era of generative models. Our key insight stems from the observation that distributional…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Jun Nie , Yonggang Zhang , Tongliang Liu , Yiu-ming Cheung , Bo Han , Xinmei Tian

In order to estimate a registration model of eye fundus images made of an affinity and two radial distortions, we introduce an estimation criterion based on an error between the vessels. In [1], we estimated this model by minimising the…

Medical Physics · Physics 2019-07-22 Guillaume Noyel , R Thomas , S Iles , G Bhakta , A Crowder , D. Owens , P. Boyle

Artificial intelligence (AI) systems accelerate medical workflows and improve diagnostic accuracy in healthcare, serving as second-opinion systems. However, the unpredictability of AI errors poses a significant challenge, particularly in…

Deep learning models have the capacity to fundamentally revolutionize medical imaging analysis, and they have particularly interesting applications in computer-aided diagnosis. We attempt to use deep learning neural networks to diagnose…

Machine Learning · Computer Science 2020-02-24 Rohit Jammula , Vishnu Rajan Tejus , Shreya Shankar

Diabetic Retinopathy (DR) is a leading cause of vision loss globally. Yet despite its prevalence, the majority of affected people lack access to the specialized ophthalmologists and equipment required for assessing their condition. This can…

Computer Vision and Pattern Recognition · Computer Science 2021-10-22 Alexandros Papadopoulos , Fotis Topouzis , Anastasios Delopoulos

There has been a growing interest in deep learning-based prognostic and health management (PHM) for building end-to-end maintenance decision support systems, especially due to the rapid development of autonomous systems. However, the low…

Machine Learning · Computer Science 2021-11-02 Taotao Zhou , Enrique Lopez Droguett , Ali Mosleh , Felix T. S. Chan

Retinal fundus photography offers a non-invasive way to diagnose and monitor a variety of retinal diseases, but is prone to inherent quality glitches arising from systemic imperfections or operator/patient-related factors. However,…

Image and Video Processing · Electrical Eng. & Systems 2024-09-13 Vamsi Krishna Vasa , Peijie Qiu , Wenhui Zhu , Yujian Xiong , Oana Dumitrascu , Yalin Wang

Traditional machine learning follows a close-set assumption that the training and test set share the same label space. While in many practical scenarios, it is inevitable that some test samples belong to unknown classes (open-set). To fix…

Machine Learning · Computer Science 2023-02-23 Zitai Wang , Qianqian Xu , Zhiyong Yang , Yuan He , Xiaochun Cao , Qingming Huang

From uncertainty quantification to real-world object detection, we recognize the importance of machine learning algorithms, particularly in safety-critical domains such as autonomous driving or medical diagnostics. In machine learning,…

Computer Vision and Pattern Recognition · Computer Science 2025-05-29 Carina Newen , Luca Hinkamp , Maria Ntonti , Emmanuel Müller

WHO has declared that more than 2.2 billion people worldwide are suffering from visual disorders, such as media haze, glaucoma, and drusen. At least 1 billion of these cases could have been either prevented or successfully treated, yet they…

Image and Video Processing · Electrical Eng. & Systems 2024-05-30 Yavuz Selim Inan

Diabetic retinopathy (DR) grading is crucial in determining the adequate treatment and follow up of patients, but the screening process can be tiresome and prone to errors. Deep learning approaches have shown promising performance as…

Image and Video Processing · Electrical Eng. & Systems 2020-06-01 Teresa Araújo , Guilherme Aresta , Luís Mendonça , Susana Penas , Carolina Maia , Ângela Carneiro , Ana Maria Mendonça , Aurélio Campilho

Machine-learned diagnosis models have shown promise as medical aides but are trained under a closed-set assumption, i.e. that models will only encounter conditions on which they have been trained. However, it is practically infeasible to…

Machine Learning · Computer Science 2019-10-08 Viraj Prabhu , Anitha Kannan , Geoffrey J. Tso , Namit Katariya , Manish Chablani , David Sontag , Xavier Amatriain

Retinal imaging has emerged as a powerful, non-invasive modality for detecting and quantifying biomarkers of systemic diseases-ranging from diabetes and hypertension to Alzheimer's disease and cardiovascular disorders but current insights…

Image and Video Processing · Electrical Eng. & Systems 2025-05-28 Tariq M Khan , Toufique Ahmed Soomro , Imran Razzak

The operating environment of a highly automated vehicle is subject to change, e.g., weather, illumination, or the scenario containing different objects and other participants in which the highly automated vehicle has to navigate its…

Computer Vision and Pattern Recognition · Computer Science 2024-04-18 Florian Heidecker , Ahmad El-Khateeb , Maarten Bieshaar , Bernhard Sick

Traditionally, medical discoveries are made by observing associations and then designing experiments to test these hypotheses. However, observing and quantifying associations in images can be difficult because of the wide variety of…

Computer Vision and Pattern Recognition · Computer Science 2020-06-19 Ryan Poplin , Avinash V. Varadarajan , Katy Blumer , Yun Liu , Michael V. McConnell , Greg S. Corrado , Lily Peng , Dale R. Webster
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