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Explainable Artificial Intelligence (XAI) is essential for the transparency and clinical adoption of Clinical Decision Support Systems (CDSS). However, the real-world effectiveness of existing XAI methods remains limited and is…

Machine Learning · Computer Science 2026-01-26 Alessandro Gambetti , Qiwei Han , Hong Shen , Claudia Soares

This paper explores the significant impact of AI-based medical devices, including wearables, telemedicine, large language models, and digital twins, on clinical decision support systems. It emphasizes the importance of producing outcomes…

Artificial Intelligence · Computer Science 2024-04-11 Elham Nasarian , Roohallah Alizadehsani , U. Rajendra Acharya , Kwok-Leung Tsui

High predictive performance and ease of use and interpretability are important requirements for the applicability of a computer-aided diagnosis (CAD) to human reading studies. We propose a CAD system specifically designed to be more…

Machine Learning · Statistics 2016-06-28 Cristina Gallego-Ortiz , Anne L. Martel

Artificial intelligence (AI) is expected to significantly enhance radio resource management (RRM) in sixth-generation (6G) networks. However, the lack of explainability in complex deep learning (DL) models poses a challenge for practical…

Signal Processing · Electrical Eng. & Systems 2025-01-24 Nasir Khan , Asmaa Abdallah , Abdulkadir Celik , Ahmed M. Eltawil , Sinem Coleri

Machine learning is frequently used in affective computing, but presents challenges due the opacity of state-of-the-art machine learning methods. Because of the impact affective machine learning systems may have on an individual's life, it…

Machine Learning · Computer Science 2025-10-07 David S. Johnson , Olya Hakobyan , Hanna Drimalla

In response to the COVID-19 pandemic, the integration of interpretable machine learning techniques has garnered significant attention, offering transparent and understandable insights crucial for informed clinical decision making. This…

Machine Learning · Computer Science 2024-09-10 Jinzhi Shen , Ke Ma

The rapid evolution of artificial intelligence, especially in large language models (LLMs), has significantly impacted various domains, including healthcare. In chest X-ray (CXR) analysis, previous studies have employed LLMs, but with…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Jonggwon Park , Soobum Kim , Byungmu Yoon , Jihun Hyun , Kyoyun Choi

Breast cancer is the most common cancers and early detection from mammography screening is crucial in improving patient outcomes. Assessing mammographic breast density is clinically important as the denser breasts have higher risk and are…

Image and Video Processing · Electrical Eng. & Systems 2022-06-27 Charles Lu , Ken Chang , Praveer Singh , Jayashree Kalpathy-Cramer

Artificial intelligence (AI) has increasingly transformed medical prognostics by enabling rapid and accurate analysis across imaging and pathology. However, the investigation of machine learning predictions applied to prospectively…

Understanding model predictions is critical in healthcare, to facilitate rapid verification of model correctness and to guard against use of models that exploit confounding variables. We introduce the challenging new task of explainable…

Image and Video Processing · Electrical Eng. & Systems 2022-08-23 Rachel Lea Draelos , Lawrence Carin

We present ReXVQA, the largest and most comprehensive benchmark for visual question answering (VQA) in chest radiology, comprising approximately 696,000 questions paired with 160,000 chest X-rays studies across training, validation, and…

Computer Vision and Pattern Recognition · Computer Science 2025-06-06 Ankit Pal , Jung-Oh Lee , Xiaoman Zhang , Malaikannan Sankarasubbu , Seunghyeon Roh , Won Jung Kim , Meesun Lee , Pranav Rajpurkar

In this study, a novel computer aided diagnosis (CADx) framework is devised to investigate interpretability for classifying breast masses. Recently, a deep learning technology has been successfully applied to medical image analysis…

Computer Vision and Pattern Recognition · Computer Science 2018-05-24 Seong Tae Kim , Hakmin Lee , Hak Gu Kim , Yong Man Ro

Automatic radiology report generation is a promising application of multimodal deep learning, aiming to reduce reporting workload and improve consistency. However, current state-of-the-art (SOTA) systems - such as Multimodal AI for…

Foundation models leveraging vision-language pretraining have shown promise in chest X-ray (CXR) interpretation, yet their real-world performance across diverse populations and diagnostic tasks remains insufficiently evaluated. This study…

A major obstacle to the integration of deep learning models for chest x-ray interpretation into clinical settings is the lack of understanding of their failure modes. In this work, we first investigate whether there are patient subgroups…

Computer Vision and Pattern Recognition · Computer Science 2021-07-21 Emma Chen , Andy Kim , Rayan Krishnan , Jin Long , Andrew Y. Ng , Pranav Rajpurkar

Objective. This paper presents an overview of generalizable and explainable artificial intelligence (XAI) in deep learning (DL) for medical imaging, aimed at addressing the urgent need for transparency and explainability in clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-03-12 Ahmad Chaddad , Yan Hu , Yihang Wu , Binbin Wen , Reem Kateb

Recent advancements in artificial intelligence (AI) have facilitated its widespread adoption in primary medical services, addressing the demand-supply imbalance in healthcare. Vision Transformers (ViT) have emerged as state-of-the-art…

Computer Vision and Pattern Recognition · Computer Science 2023-09-04 Tin Lai

Staging of liver fibrosis is important in the diagnosis and treatment planning of patients suffering from liver diseases. Current deep learning-based methods using abdominal magnetic resonance imaging (MRI) usually take a sub-region of the…

Computer Vision and Pattern Recognition · Computer Science 2023-06-22 Zheyao Gao , Yuanye Liu , Fuping Wu , NanNan Shi , Yuxin Shi , Xiahai Zhuang

Convolutional Neural Networks (CNNs) are frequently and successfully used in medical prediction tasks. They are often used in combination with transfer learning, leading to improved performance when training data for the task are scarce.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-22 Marta Oliveira , Rick Wilming , Benedict Clark , Céline Budding , Fabian Eitel , Kerstin Ritter , Stefan Haufe

The lack of transparency of data-driven Artificial Intelligence techniques limits their interpretability and acceptance into healthcare decision-making processes. We propose an attribution-based approach to improve the interpretability of…

Artificial Intelligence · Computer Science 2025-07-09 Alessandro Umbrico , Guido Bologna , Luca Coraci , Francesca Fracasso , Silvia Gola , Gabriella Cortellessa