Related papers: Effectiveness of iNTS vaccination in Sub-Saharan A…
Malaria is the leading cause of death globally, especially in sub-Saharan African countries claiming over 400,000 deaths globally each year, underscoring the critical need for continued efforts to combat this preventable and treatable…
The WHO 2021 malaria report revealed that its Global Technical Strategy (GTS) 2020 milestones for morbidity and mortality, based on the 2015 baseline, have not been achieved globally -- the world is off-track by 42% and, can be extended up…
We model the impact of local vaccine mandates on the spread of vaccine-preventable infectious diseases, which in the absence of vaccines will mainly affect children. Examples of such diseases are measles, rubella, mumps and pertussis. To…
According to the WHO, in 2021, about 32% of pregnant women in sub-Saharan Africa were infected with malaria during pregnancy. Malaria infection during pregnancy can cause various adverse birth outcomes such as low birthweight. Over the past…
Recently developed vaccines provide a new way of controlling rotavirus in sub-Saharan Africa. Models for the transmission dynamics of rotavirus are critical both for estimating current burden from imperfect surveillance and for assessing…
This study aims to statistically assess the effectiveness of vaccination against SARS-CoV-2. It is indispensable to investigate the relationship between Covid-19 deadliness and vaccination in order to study the impact of vaccine in…
In a study of the heterogeneity in malaria infection rates among children Smith et al.1 fitted several mathematical models to data from community studies in Africa. They concluded that 20% of children receive 80% of infections, that…
Measles is a significant source of global disease burden and child mortality. Measles vaccination through routine immunization (RI) programs in high-burden settings remains a challenge due to poor health care infrastructure and access.…
Mass campaigns with antimalarial drugs are potentially a powerful tool for local elimination of malaria, yet current diagnostic technologies are insufficiently sensitive to identify all individuals who harbor infections. At the same time,…
Malaria is one of the deadliest infectious diseases globally, causing hundreds of thousands of deaths each year. It disproportionately affects young children, with two-thirds of fatalities occurring in under-fives. Individuals acquire…
South Africa has more people infected with HIV but, by providing access to anti-retroviral therapy (ART), has kept more people alive than any other country. The effectiveness, availability and affordability of potent anti-retroviral therapy…
The latest WHO report showed that the number of malaria cases climbed to 219 million last year, two million higher than last year. The global efforts to fight malaria have hit a plateau and the most significant underlying reason is…
This is an epidemiological SIRV model based study that is designed to analyze the impact of vaccination in containing infection spread, in a 4-tiered population compartment comprised of susceptible, infected, recovered and vaccinated…
We develop a variable population age-structured ODE model to investigate the role of Intermittent Preventive Treatment (IPT) in averting malaria-induced mortalities in children, as well as its related cost in promoting the spread of…
This study estimates the overall effect of two influenza vaccination programs consecutively administered in a cluster-randomized trial in western Senegal over the course of two influenza seasons from 2009-2011. We apply cutting-edge…
This study assesses the impact of COVID-19 vaccines through an epidemiological model that quantifies their role in pandemic control. We analyze an SIR-based model incorporating vaccination effects and calculate the basic reproduction…
Malaria, childhood acute respiratory infection, and child undernutrition together account for over two million deaths annually in children under five, with the burden concentrated in low and middle-income countries where climate variability…
Malaria is a life threatening disease, entirely preventable and treatable, provided the currently recommended interventions are properly implemented. These interventions include vector control through the use of insecticide-treated nets…
The Susceptible-Infected-Susceptible (SIS) model is a widely used model for the spread of information and infectious diseases, particularly non-immunizing ones, on a graph. Given a highly contagious disease, a natural question is how to…
Malaria can be prevented, diagnosed, and treated; however, every year, there are more than 200 million cases and 200.000 preventable deaths. Malaria remains a pressing public health concern in low- and middle-income countries, especially in…