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Motility is an essential factor for an organism's survival and diversification. With the advent of novel single-cell technologies, analytical frameworks and theoretical methods, we can begin to probe the complex lives of microscopic motile…

In this work, we report a direct measurement of the forces exerted by a tubulin/kinesin active nematic gel as well as its complete rheological characterization, including the quantification of its shear viscosity, {\eta}, and its activity…

Soft Condensed Matter · Physics 2024-04-22 Ignasi Vélez-Cerón , Pau Guillamat , Francesc Sagués , Jordi Ignés-Mullol

Active matter consumes energy from the environment and transforms it into mechanical work. Notable examples from biology include cell division, bacterial swarms, and muscle contraction. In this work, we investigate the nature of active…

Soft Condensed Matter · Physics 2023-09-28 Michael J. Landry

In this review we summarize theoretical progress in the field of active matter, placing it in the context of recent experiments. Our approach offers a unified framework for the mechanical and statistical properties of living matter:…

Soft Condensed Matter · Physics 2012-07-13 M. C. Marchetti , J. -F. Joanny , S. Ramaswamy , T. B. Liverpool , J. Prost , Madan Rao , R. Aditi Simha

We analyse a generic motility model, with the motility mechanism arising by contractile stress due to the interaction of myosin and actin. A hydrodynamic active polar gel theory is used to model the cytoplasm of a cell and is combined with…

Cell Behavior · Quantitative Biology 2015-07-06 Wieland Marth , Simon Praetorius , Axel Voigt

Complex interactions between cellular systems and their surrounding extracellular matrices are emerging as important mechanical regulators of cell functions such as proliferation, motility, and cell death, and such cellular systems are…

Soft Condensed Matter · Physics 2021-04-16 Emmanuel L. C. VI M. Plan , Julia M. Yeomans , Amin Doostmohammadi

We study a model of an active gel of cross-linked semiflexible filaments with additional active linkers such as myosin II clusters. We show that the coupling of the elasticity of the semiflexible filaments to the mechanical properties of…

Soft Condensed Matter · Physics 2009-11-13 T. B. Liverpool , M. C. Marchetti , J. -F. Joanny , J. Prost

Mesoscopic active systems exhibit various unique behaviours - absent in passive systems - due to the forces generated by the corresponding constituents by converting their available free energies. However, estimating these forces - which…

Active contributions to fluctuations are a direct consequence of metabolic energy consumption in living cells. Such metabolic processes continuously create active forces, which deform the membrane to control motility, proliferation as well…

Biological Physics · Physics 2018-10-02 Hervé Turlier , Timo Betz

Animal cells are active, contractile objects. While bioassays address the molecular characterization of cell contractility, the mechanical characterization of the active forces in cells remains challenging. Here by confronting theoretical…

Cell Behavior · Quantitative Biology 2022-09-14 Hélène Delanoë-Ayari , Nicolas Bouchonville , Marie Courçon , Alice Nicolas

We use Langevin dynamics simulations to study dynamical behaviour of a dense planar layer of active semi-flexible filaments. Using the strength of active force and the thermal persistence length as parameters, we map a detailed phase…

Soft Condensed Matter · Physics 2018-02-21 K. R. Prathyusha , Silke Henkes , Rastko Sknepnek

Growth patterns generated by filamentous organisms (e.g. actinomycetes and fungi) involve spatial and temporal dynamics at different length scales. Several mathematical models have been proposed in the last thirty years to address these…

Populations and Evolution · Quantitative Biology 2007-05-23 Michele Bezzi , Andrea Ciliberto

The study of cells' dynamical properties is essential to a better understanding of several physiological processes. These properties are directly associated with cells' mechanical parameters experimentally achieved through physical stress.…

Soft Condensed Matter · Physics 2022-01-26 G. Ourique , E. F. Teixeira , L. G. Brunnet

The production of mechanical stresses in living organisms largely relies on localized, force-generating active units embedded in filamentous matrices. Numerical simulations of discrete fiber networks with fixed boundaries have shown that…

Biological Physics · Physics 2018-05-10 Pierre Ronceray , Chase Broedersz , Martin Lenz

Developing tissues need to pattern themselves in space and time. A prevalent mechanism to achieve this are pulsatile active stresses generated by the actin cytoskeleton. Active gel theory is a powerful tool to model the dynamics of…

Biological Physics · Physics 2023-02-21 Eloy Merlijn de Kinkelder , Elisabeth Fischer-Friedrich , Sebastian Aland

Many active materials and biological systems are driven far from equilibrium by embedded agents that spontaneously generate forces and distort the surrounding material. Probing and characterizing these athermal fluctuations is essential for…

Materials Science · Physics 2015-05-18 D. A. Head , D. Mizuno

The dynamics of active viscoelastic surfaces plays an important role in biological systems. One prominent example is the actin cortex, a thin bio-polymer sheet underneath the outer membrane of biological cells which combines active…

Activity and autonomous motion are fundamental in living and engineering systems. This has stimulated the new field of active matter in recent years, which focuses on the physical aspects of propulsion mechanisms, and on motility-induced…

High-throughput characterization of architected materials across a wide range of length scales enables rapid screening of topologies for engineering applications. Scaled-down specimens manufactured and evaluated in laboratory environments…

Materials Science · Physics 2026-05-05 Vatsa Gandhi , Rishi Kommalapati , Carlos M. Portela , Vikram Deshpande

The symmetry breaking of the actin network from radial to longitudinal symmetry has been identified as the major mechanism for keratocytes (fish cells) motility on solid substrate. For strong friction coefficient, the two dimensional actin…

Soft Condensed Matter · Physics 2011-02-16 M. Ben Amar , O. V. Manyuhina , G. Napoli