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We introduce a fingerprint representation of molecules based on a Fourier series of atomic radial distribution functions. This fingerprint is unique (except for chirality), continuous, and differentiable with respect to atomic coordinates…

Chemical Physics · Physics 2015-03-18 O. Anatole von Lilienfeld , Raghunathan Ramakrishnan , Matthias Rupp , Aaron Knoll

Quantum machine learning (QML) has attracted growing interest with the rapid parallel advances in large-scale classical machine learning and quantum technologies. Similar to classical machine learning, QML models also face challenges…

Chemical compound space (CCS), the set of all theoretically conceivable combinations of chemical elements and (meta-)stable geometries that make up matter, is colossal. The first principles based virtual sampling of this space, for example…

Chemical Physics · Physics 2021-06-23 Bing Huang , O. Anatole von Lilienfeld

Molecular dynamics (MD) simulations allow atomistic insights into chemical and biological processes. Accurate MD simulations require computationally demanding quantum-mechanical calculations, being practically limited to short timescales…

Quantum machine learning (QML) is a discipline that seeks to transfer the advantages of quantum computing to data-driven tasks. However, many studies rely on toy datasets or heavy feature reduction, raising concerns about their scalability.…

Quantum Physics · Physics 2025-04-16 Federico Tiblias , Anna Schroeder , Yue Zhang , Mariami Gachechiladze , Iryna Gurevych

Highly accurate force fields are a mandatory requirement to generate predictive simulations. In this regard, Machine Learning Force Fields (MLFFs) have emerged as a revolutionary approach in computational chemistry and materials science,…

Materials Science · Physics 2025-03-11 Carlos A. Vital , Román J. Armenta-Rico , Huziel E. Sauceda

Multiple kernel learning (MKL) algorithms combine different base kernels to obtain a more efficient representation in the feature space. Focusing on discriminative tasks, MKL has been used successfully for feature selection and finding the…

Machine Learning · Computer Science 2019-03-14 Babak Hosseini , Barbara Hammer

Quantum federated learning (QFL) can facilitate collaborative learning across multiple clients using quantum machine learning (QML) models, while preserving data privacy. Although recent advances in QFL span different tasks like…

Machine Learning · Computer Science 2023-12-25 Mahdi Chehimi , Samuel Yen-Chi Chen , Walid Saad , Shinjae Yoo

Binding free energies are a key element in understanding and predicting the strength of protein--drug interactions. While classical free energy simulations yield good results for many purely organic ligands, drugs including transition metal…

The representations of a compound, called "descriptors" or "features", play an essential role in constructing a machine-learning model of its physical properties. In this study, we adopt a procedure for generating a systematic set of…

Materials Science · Physics 2017-04-26 Atsuto Seko , Hiroyuki Hayashi , Keita Nakayama , Akira Takahashi , Isao Tanaka

Density-functional theory (DFT) has become the workhorse of modern computational chemistry, with dispersion corrections such as the exchange-hole dipole moment (XDM) model playing a key role in high-accuracy modelling of large-scale…

Chemical Physics · Physics 2026-05-22 Kyle R. Bryenton , Erin R. Johnson

The abundant demand for deep learning compute resources has created a renaissance in low precision hardware. Going forward, it will be essential for simulation software to run on this new generation of machines without sacrificing…

Chemical Physics · Physics 2024-10-23 William Dawson , Katsuhisa Ozaki , Jens Domke , Takahito Nakajima

Molecular dynamics (MD) simulates the time evolution of atomic systems governed by interatomic forces, and the fidelity of these simulations depends critically on the underlying force model. Classical force fields (CFFs) rely on fixed…

Performance · Computer Science 2026-03-05 Udari De Alwis , Benjamin E. Mayer , Tom J. Ashby , Maria Barrera , Timon Evenblij , Joyjit Kundu

Learning from data has led to paradigm shifts in a multitude of disciplines, including web, text, and image search, speech recognition, as well as bioinformatics. Can machine learning enable similar breakthroughs in understanding quantum…

A state-of-the-art method that combines a quantum computational algorithm and machine learning, so-called quantum machine learning, can be a powerful approach for solving quantum many-body problems. However, the research scope in the field…

Computational Physics · Physics 2023-04-04 Shu Kanno , Tomofumi Tada

Multi-task learning (MTL) improves generalization and data efficiency by jointly learning related tasks through shared representations. In the widely used hard-parameter-sharing setting, a shared backbone is combined with task-specific…

Machine Learning · Computer Science 2026-04-16 Hevish Cowlessur , Chandra Thapa , Tansu Alpcan , Seyit Camtepe

In recent years, quantum machine learning has emerged as a promising intersection between quantum physics and artificial intelligence, particularly in domains requiring advanced pattern recognition such as healthcare. This study…

Quantum Physics · Physics 2025-06-05 My Youssef El Hafidi , Achraf Toufah , Mohamed Achraf Kadim

Accurate and efficient prediction of electronic wavefunctions is central to ab initio molecular dynamics (AIMD) and electronic structure theory. However, conventional ab initio methods require self-consistent optimization of electronic…

Chemical Physics · Physics 2025-11-12 Yanxian Tao , Lingyun Wan , Xiongzhi Zeng , Yingdi Jin , Jie Liu , Zhenyu Li , Jinlong Yang

We use a support vector regressor based on a projected quantum kernel method to predict the density structure of 1D fermionic systems of interest in quantum chemistry and quantum matter. The kernel is built on with the observables of a…

Quantum Physics · Physics 2025-09-01 Francesco Perciavalle , Francesco Plastina , Michele Pisarra , Nicola Lo Gullo

We propose a quantum feature mapping technique that leverages the quench dynamics of a quantum spin glass to extract complex data patterns at the quantum-advantage level for academic and industrial applications. We demonstrate that encoding…

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