Related papers: A comprehensive mathematical model for cardiac per…
CoronaryHemodynamics is a comprehensive simulation package developed on the OpenFOAM platform, designed specifically for coronary artery hemodynamics analysis. The package integrates a complete suite of tools for simulation preparation,…
Coronary Microvascular Dysfunction (CMD) is characterized by impaired vasodilation and can lead to insufficient blood flow to the myocardium during stress or exertion, affecting millions of people globally. Despite their diagnostic value,…
BACKGROUND: Most studies of CAD revascularization have been based on and reported according to angiographic criteria which don't consider the relation between the resulting effective flow distal to the stenosis and the demand of a…
The presented multi-scale, closed-loop blood circulation model includes arterial, venous, and portal venous systems, heart-pulmonary circulation, and micro-circulation in capillaries. One-dimensional models simulate large blood vessel flow,…
We performed numerical simulations of blood flow in arteries with a variable stiffness and cross-section at rest using a finite volume method coupled with a hydrostatic reconstruction of the variables at the interface of each mesh cell. The…
Background and Objective: This study aims to evaluate the dynamic effect of non-Newtonian cerebral arterial circulation on electrical conductivity distribution (ECD) in a realistic multi-compartment head model. It addresses the importance…
We study perfusion by a multiscale model coupling diffusion in the tissue and diffusion along the one-dimensional segments representing the vasculature. We propose a block-diagonal preconditioner for the model equations and demonstrate its…
This paper presents a nonlinear reaction-diffusion-fluid system that simulates radiofrequency ablation within cardiac tissue. The model conveys the dynamic evolution of temperature and electric potential in both the fluid and solid regions,…
Recent development of quantitative myocardial blood flow (MBF) mapping allows direct evaluation of absolute myocardial perfusion, by computing pixel-wise flow maps. Clinical studies suggest quantitative evaluation would be more desirable…
We propose four novel mathematical models, describing the microscopic mechanisms of force generation in the cardiac muscle tissue, which are suitable for multiscale numerical simulations of cardiac electromechanics. Such models are based on…
The field of cardiac electrophysiology tries to abstract, describe and finally model the electrical characteristics of a heartbeat. With recent advances in cardiac electrophysiology, models have become more powerful and descriptive as ever.…
Detection and monitoring of patients with pulmonary hypertension, defined as mean blood pressure in the main pulmonary artery above 25 mmHg, requires a combination of imaging and hemodynamic measurements. This study demonstrates how to…
The aortic valve is a three-leaflet passive structure that, driven by pressure differences between the left ventricle and the aorta, opens and closes during the heartbeat to ensure the correct stream direction and flow rate. In elderly…
We present a novel approach which aims at high-performance uncertainty quantification for cardiac electrophysiology simulations. Employing the monodomain equation to model the transmembrane potential inside the cardiac cells, we evaluate…
This study investigates the hemodynamic behavior of blood flow in the aortic arch across anemic, diabetic, and healthy conditions using computational fluid dynamics (CFD) simulations with a non-Newtonian Carreau viscosity model. Velocity…
Predictive modeling of blood flow and pressure have numerous applications ranging from non-invasive assessment of functional significance of disease to planning invasive procedures. While several such predictive modeling techniques have…
Motion free reconstruction of compressively sampled cardiac perfusion MR images is a challenging problem. It is due to the aliasing artifacts and the rapid contrast changes in the reconstructed perfusion images. In addition to the…
Magnetic Resonance cardiac diffusion tensor imaging (cDTI) and cardiac intravoxel incoherent motion imaging enables probing of in vivo myofiber architecture and myocardial perfusion surrogates. To study the impact of experimental parameters…
We study the impact of using fluid-structure interactions (FSI) to simulate blood flow in a large stenosed artery. We compare typical flow configurations using Navier-Stokes in a rigid geometry setting to a fully coupled FSI model. The…
We propose a hemodynamic reduced-order model bridging macroscopic and meso-scopic blood flow circulation scales from arteries to capillaries. In silico tree like vascular geometries, mathematically described by graphs, are synthetically…