Related papers: A comprehensive mathematical model for cardiac per…
We present a new computational model for the numerical simulation of blood flow in the human left heart. To this aim, we use the Navier-Stokes equations in an Arbitrary Lagrangian Eulerian formulation to account for the endocardium motion…
We propose a mathematical and numerical model for the simulation of the heart function that couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and includes reduced models for cardiac valves and the circulatory…
Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin, flexible valve leaflets. There has been longstanding scientific, engineering,…
We introduce a Darcy-scale model to describe compressible multi-component flow in a fully saturated porous medium. In order to capture cross-diffusive effects between the different species correctly, we make use of the Maxwell--Stefan…
The circulatory system, comprising the heart and blood vessels, is vital for nutrient transport, waste removal, and homeostasis. Traditional computational models often treat cardiac electromechanics and blood flow dynamics separately,…
In this paper, we are concerned with the simulation of blood flow in microvascular networks and the surrounding tissue. To reduce the computational complexity of this issue, the network structures are modeled by a one-dimensional graph,…
We introduce a multiphysics and geometric multiscale computational model, suitable to describe the hemodynamics of the whole human heart, driven by a four-chamber electromechanical model. We first present a study on the calibration of the…
We propose an integrated electromechanical model of the human heart, with focus on the left ventricle, wherein biophysically detailed models describe the different physical phenomena concurring to the cardiac function. We model the…
This brief article accompanies a fluid dynamics video presenting the results of a large-eddy simulation of the flow in a realistic left heart. The left heart geometry, from the pulmonary veins to the aortic root, is extracted from medical…
Numerical simulations of real-world phenomena require a computational scheme and a computational domain. In the context of haemodynamics, the computational domain is the blood vessel network through which blood flows. Such networks contain…
Computational fluid dynamics (CFD) is increasingly used to study blood flows in patient-specific arteries for understanding certain cardiovascular diseases. The techniques work quite well for relatively simple problems, but need…
Intracardiac flow patterns are shaped by the coupled motion of the cardiac chambers and heart valves and provide important information about cardiac function. However, clinical flow imaging remains limited by exam times, noise, resolution,…
Arrhythmias are potentially fatal disruptions to the normal heart rhythm, but their underlying dynamics is still poorly understood. Theoretical modeling is an important tool to fill this gap. Typical studies often employ detailed…
Computer modeling can provide quantitative insight into cardiac fluid dynamics phenomena that are not evident from standard imaging tools. We propose a new approach to modeling left ventricle fluid dynamics based on an image-driven…
In this paper we will address the problem of developing mathematical models for the numerical simulation of the human circulatory system. In particular, we will focus our attention on the problem of haemodynamics in large human arteries.
We present a Lagrangian analysis of turbulent blood flow in the human left heart using high-fidelity simulations based on a patient-specific anatomical model. Leveraging a fully coupled fluid-structure-electrophysiology interaction (FSEI)…
Numerical simulations to evaluate thoracic aortic hemodynamics include a computational fluid dynamic (CFD) approach or fluid-structure interaction (FSI) approach. While CFD neglects the arterial deformation along the cardiac cycle by…
Purpose: Tracer-kinetic models can be used for the quantitative assessment of contrast-enhanced MRI data. However, the model-fitting can produce unreliable results due to the limited data acquired and the high noise levels. Such problems…
This work presents a biventricular electromechanical human heart model that is comprehensive and clinically relevant, integrating a realistic 3D heart geometry with both systemic and pulmonary hemodynamics. The model uses a two-way…
In this study, we present a comprehensive numerical analysis of blood flow within human left ventricle models, with particular emphasis on optimizing simulation conditions to enhance the realism and computational efficiency of heart flow…