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Reference-guided DNA sequencing and alignment is an important process in computational molecular biology. The amount of DNA data grows very fast, and many new genomes are waiting to be sequenced while millions of private genomes need to be…

DNA sequencing allows for the determination of the genetic code of an organism, and therefore is an indispensable tool that has applications in Medicine, Life Sciences, Evolutionary Biology, Food Sciences and Technology, and Agriculture. In…

Quantum Physics · Physics 2023-04-24 Nouhaila Innan , Muhammad Al-Zafar Khan

Computing the similarity between two DNA sequences is of vital importance in bioscience, yet it can be computationally expensive on classical hardware. For example, the edit distance with move operations (EDM), a DNA similarity measure of…

Quantum Physics · Physics 2025-12-03 Chenyu Shi , Gabriele Leoni , Mauro Petrillo , Antonio Puertas Gallardo , Hao Wang

Genetic algorithms are heuristic optimization techniques inspired by Darwinian evolution. Quantum computation is a new computational paradigm which exploits quantum resources to speed up information processing tasks. Therefore, it is…

Quantum Physics · Physics 2023-02-20 Rubén Ibarrondo , Giancarlo Gatti , Mikel Sanz

Drug discovery has become a main challenge in our society, following the Covid-19 pandemic. Even pharmaceutical companies are already using computing to accelerate drug discovery. They are increasingly interested in Quantum Computing with a…

Quantum Physics · Physics 2024-02-16 Anthony Chagneau , Yousra Massaoudi , Imene Derbali , Linda Yahiaoui

Replication of DNA and synthesis of proteins are studied from the view-point of quantum database search. Identification of a base-pairing with a quantum query gives a natural (and first ever) explanation of why living organisms have 4…

Quantum Physics · Physics 2009-11-06 Apoorva Patel

String matching algorithm plays the vital role in the Computational Biology. The functional and structural relationship of the biological sequence is determined by similarities on that sequence. For that, the researcher is supposed to aware…

Data Structures and Algorithms · Computer Science 2014-01-30 Pandiselvam. P , Marimuthu. T , Lawrance. R

Sequence Alignment is the process of aligning biological sequences in order to identify similarities between multiple sequences. In this paper, a Quantum Algorithm for finding the optimal alignment between DNA sequences has been…

Data Structures and Algorithms · Computer Science 2025-09-05 Md. Rabiul Islam Khan , Shadman Shahriar , Shaikh Farhan Rafid

Biological sequence comparison is a key step in inferring the relatedness of various organisms and the functional similarity of their components. Thanks to the Next Generation Sequencing efforts, an abundance of sequence data is now…

Machine Learning · Computer Science 2016-09-13 Dhananjay Kimothi , Akshay Soni , Pravesh Biyani , James M. Hogan

We propose a modified MSA algorithm on quantum annealers with applications in areas of bioinformatics and genetic sequencing. To understand the human genome, researchers compare extensive sets of these genetic sequences -- or their protein…

Quantum Physics · Physics 2024-03-28 Melody Lee

The search for meaningful structure in biological data has relied on cutting-edge advances in computational technology and data science methods. However, challenges arise as we push the limits of scale and complexity in biological problems.…

We consider the problem of distinguishing two vectors (visualized as images or barcodes) and learning if they are related to one another. For this, we develop a geometric quantum machine learning (GQML) approach with embedded symmetries…

Quantum Physics · Physics 2024-09-04 Chukwudubem Umeano , Stefano Scali , Oleksandr Kyriienko

Computational complexity is a key limitation of genomic analyses. Thus, over the last 30 years, researchers have proposed numerous fast heuristic methods that provide computational relief. Comparing genomic sequences is one of the most…

The rapid development of reliable Quantum Processing Units (QPU) opens up novel computational opportunities for machine learning. Here, we introduce a procedure for measuring the similarity between graph-structured data, based on the…

Quantum Physics · Physics 2021-09-29 Louis-Paul Henry , Slimane Thabet , Constantin Dalyac , Loïc Henriet

In the context of evolutionary quantum computing in the literal meaning, a quantum crossover operation has not been introduced so far. Here, we introduce a novel quantum genetic algorithm which has a quantum crossover procedure performing…

Neural and Evolutionary Computing · Computer Science 2014-02-05 Akira SaiToh , Robabeh Rahimi , Mikio Nakahara

Computational methods are the most effective tools we have besides scientific experiments to explore the properties of complex biological systems. Progress is slowing because digital silicon computers have reached their limits in terms of…

Quantum Physics · Physics 2020-04-03 Viv Kendon

In genomics, pattern matching against a sequence of nucleotides plays a pivotal role for DNA sequence alignment and comparing genomes. This helps tackling some diseases, such as cancer in humans. The complexity of searching biological…

Quantitative Methods · Quantitative Biology 2017-10-04 Fereshte Mozafari , Hossein Babashah , Somayyeh Koohi , Zahra Kavehvash

Solving linear systems of equations is ubiquitous in all areas of science and engineering. With rapidly growing data sets, such a task can be intractable for classical computers, as the best known classical algorithms require a time…

DNA sequencing to identify genetic variants is becoming increasingly valuable in clinical settings. Assessment of variants in such sequencing data is commonly implemented through Bayesian heuristic algorithms. Machine learning has shown…

We report an algorithm, based on quantum optics formulation, where a coherent state is used as the elementary quantum resource for the image representation. We provide an architecture with constituent optical elements in linear order with…

Quantum Physics · Physics 2024-10-01 Vivek Mehta , Sonali Jana , Utpal Roy
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