Related papers: Associating Frailty and Dynamic Dysregulation betw…
Background: Aortic stenosis (AS) is the most common acquired valvar disease and is associated with increased risk for frailty. Frailty as a geriatric syndrome is associated with muscle weakness and a compromised autonomic nervous system…
Frailty and functional decline strongly influence treatment tolerance and outcomes in older patients with cancer, yet assessment is typically limited to infrequent clinic visits. We propose a multimodal wearable framework to estimate…
To better understand mortality change with age capturing the variability in individuals' rates of aging, we performed comprehensive analysis of statistical properties of a cumulative index of age-associated disorders (deficits), called a…
Background: Frailty, a state of increased vulnerability to adverse health outcomes, has garnered significant attention in research and clinical practice. Existing constructs aggregate clinical features or health deficits into a single…
Cardiovascular diseases are best diagnosed using multiple modalities that assess both the heart's electrical and mechanical functions. While effective, imaging techniques like echocardiography and nuclear imaging are costly and not widely…
We predict the Fried physical frailty phenotype health deficits (FPFP5: slow gait, weakness, weight loss, low activity, and exhaustion) using two measures of frailty: frailty index (FI) or frailty phenotype (FP). The FP theorizes that the…
The overarching goal of the present work is to contribute to the understanding of the relations between fetal heart rate (FHR) temporal dynamics and the well-being of the fetus, notably in terms of predicting cardiovascular decompensation…
Identifying frail older adults in an ageing population is essential for improving healthcare services. This study proposes a composite indicator to assess individual frailty levels using administrative healthcare data. Given the complex and…
Frailty is a common and critical condition in elderly adults, which may lead to further deterioration of health. However, difficulties and complexities exist in traditional frailty assessments based on activity-related questionnaires. These…
Objective: We aimed to determine the relationship between day-to-day sleep efficiency variability and cognitive function among older adults using accelerometer data and three cognitive tests. Methods: Older adults aged 65+ with 5 days of…
To explore the mechanistic relationships between ageing, frailty and mortality, we developed a computational model in which possible health attributes are represented by the nodes of a complex network. Each node can be either damaged (i.e.…
Physical activity during hip fracture rehabilitation is essential for mitigating long-term functional decline in geriatric patients. However, it is rarely quantified in clinical practice. Existing continuous monitoring systems with…
This study addresses the challenge of predicting post-stroke rigidity by emphasizing feature interactions through graph-based explainable AI. Post-stroke rigidity, characterized by increased muscle tone and stiffness, significantly affects…
Heart failure (HF) affects 11.8% of adults aged 65 and older, reducing quality of life and longevity. Preventing HF can reduce morbidity and mortality. We hypothesized that artificial intelligence (AI) applied to 24-hour single-lead…
The growing global elderly population is expected to increase the prevalence of frailty, posing significant challenges to healthcare systems. Frailty, a syndrome associated with ageing, is characterised by progressive health decline,…
In many countries life expectancy gains have been substantially higher than predicted by even recent forecasts. This is primarily due to increasing rates of improvement in old-age mortality not captured by existing models. In this paper we…
The fractality of human gait, namely, the long-range correlation that characterizes scale-free fluctuations of gait descriptors, such as the stride intervals during steady-state walking, depends on the well-tuned organization of the…
In this work we study the characteristics of the heart rate variability (HRV) as a function of age and gender. The analyzed data include previous results reported in the literature. The data obtained in this work expand the range of age…
Frailty is a condition in aging medicine characterized by diminished physiological reserve and increased vulnerability to stressors. However, frailty assessment remains subjective, heterogeneous, and difficult to scale in clinical practice.…
Background: The relative contribution of different aging-associated processes to the age phenotype may differ among individuals, creating variability in aging manifestations among age-peers. Capturing this variability can significantly…