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Adoption of recently developed methods from machine learning has given rise to creation of drug-discovery knowledge graphs (KG) that utilize the interconnected nature of the domain. Graph-based modelling of the data, combined with KG…

Machine Learning · Computer Science 2022-07-27 Stephen Bonner , Ufuk Kirik , Ola Engkvist , Jian Tang , Ian P Barrett

Integrating structured knowledge from Knowledge Graphs (KGs) into Large Language Models (LLMs) remains a key challenge for symbolic reasoning. Existing methods mainly rely on prompt engineering or fine-tuning, which lose structural fidelity…

Machine Learning · Computer Science 2025-05-13 Erica Coppolillo

Knowledge Graph Embedding (KGE) techniques play a pivotal role in transforming symbolic Knowledge Graphs (KGs) into numerical representations, thereby enhancing various deep learning models for knowledge-augmented applications. Unlike…

Machine Learning · Computer Science 2025-03-24 Guanglin Niu

Representation learning on a knowledge graph (KG) is to embed entities and relations of a KG into low-dimensional continuous vector spaces. Early KG embedding methods only pay attention to structured information encoded in triples, which…

Computation and Language · Computer Science 2020-01-01 Guanglin Niu , Yongfei Zhang , Bo Li , Peng Cui , Si Liu , Jingyang Li , Xiaowei Zhang

Knowledge graphs (KGs), as structured representations of real world facts, are intelligent databases incorporating human knowledge that can help machine imitate the way of human problem solving. However, KGs are usually huge and there are…

Machine Learning · Computer Science 2023-06-27 Haotian Li , Hongri Liu , Yao Wang , Guodong Xin , Yuliang Wei

Knowledge graphs are powerful tools for representing and organising complex biomedical data. Several knowledge graph embedding algorithms have been proposed to learn from and complete knowledge graphs. However, a recent study demonstrates…

Biomedical Knowledge Graphs (BKGs) integrate diverse datasets to elucidate complex relationships within the biomedical field. Effective link prediction on these graphs can uncover valuable connections, such as potential novel drug-disease…

Computation and Language · Computer Science 2025-07-01 Tien Dang , Viet Thanh Duy Nguyen , Minh Tuan Le , Truong-Son Hy

Currently, there is a rapidly increasing need for high-quality biomedical knowledge graphs (BioKG) that provide direct and precise biomedical knowledge. In the context of COVID-19, this issue is even more necessary to be highlighted.…

Artificial Intelligence · Computer Science 2020-12-03 Sendong Zhao , Bing Qin , Ting Liu , Fei Wang

Knowledge Graph Embedding (KGE) methods have gained enormous attention from a wide range of AI communities including Natural Language Processing (NLP) for text generation, classification and context induction. Embedding a huge number of…

Artificial Intelligence · Computer Science 2022-09-19 Mojtaba Moattari , Sahar Vahdati , Farhana Zulkernine

Knowledge Graphs (KG) and associated Knowledge Graph Embedding (KGE) models have recently begun to be explored in the context of drug discovery and have the potential to assist in key challenges such as target identification. In the drug…

Biomolecules · Quantitative Biology 2022-06-01 Stephen Bonner , Ian P Barrett , Cheng Ye , Rowan Swiers , Ola Engkvist , Charles Tapley Hoyt , William L Hamilton

The embedding of Biomedical Knowledge Graphs (BKGs) generates robust representations, valuable for a variety of artificial intelligence applications, including predicting drug combinations and reasoning disease-drug relationships.…

Databases · Computer Science 2023-10-17 Zhiguang Fan , Yuedong Yang , Mingyuan Xu , Hongming Chen

Knowledge Graphs have been one of the fundamental methods for integrating heterogeneous data sources. Integrating heterogeneous data sources is crucial, especially in the biomedical domain, where central data-driven tasks such as drug…

Machine Learning · Computer Science 2020-12-22 Islam Akef Ebeid , Majdi Hassan , Tingyi Wanyan , Jack Roper , Abhik Seal , Ying Ding

Knowledge Graph Embedding (KGE) aims to represent entities and relations of knowledge graph in a low-dimensional continuous vector space. Recent works focus on incorporating structural knowledge with additional information, such as entity…

Computation and Language · Computer Science 2018-08-14 Kai Wang , Yu Liu , Xiujuan Xu , Dan Lin

Most knowledge graph embedding (KGE) methods tailored for link prediction focus on the entities and relations in the graph, giving little attention to other literal values, which might encode important information. Therefore, some…

Machine Learning · Computer Science 2025-04-02 Antonis Klironomos , Baifan Zhou , Zhuoxun Zheng , Gad-Elrab Mohamed , Heiko Paulheim , Evgeny Kharlamov

Motivation: Biomedical knowledge graphs (KGs) are crucial for drug discovery and disease understanding, yet their completion and reasoning are challenging. Knowledge Embedding (KE) methods capture global semantics but struggle with dynamic…

Artificial Intelligence · Computer Science 2025-07-23 Yitong Lin , Jiaying He , Jiahe Chen , Xinnan Zhu , Jianwei Zheng , Tao Bo

Knowledge graph (KG) reasoning is an important problem for knowledge graphs. In this paper, we propose a novel and principled framework called \textbf{RulE} (stands for {Rul}e {E}mbedding) to effectively leverage logical rules to enhance KG…

Artificial Intelligence · Computer Science 2024-05-21 Xiaojuan Tang , Song-Chun Zhu , Yitao Liang , Muhan Zhang

As large language models (LLMs) continue to grow in size, their abilities to tackle complex tasks have significantly improved. However, issues such as hallucination and the lack of up-to-date knowledge largely remain unresolved. Knowledge…

Artificial Intelligence · Computer Science 2026-03-17 Lihui Liu

Knowledge graph embedding (KGE) is a technique that enhances knowledge graphs by addressing incompleteness and improving knowledge retrieval. A limitation of the existing KGE models is their underutilization of ontologies, specifically the…

Social and Information Networks · Computer Science 2025-04-07 Takanori Ugai

Recently, Hyper-relational Knowledge Graphs (HKGs) have been proposed as an extension of traditional Knowledge Graphs (KGs) to better represent real-world facts with additional qualifiers. As a result, researchers have attempted to adapt…

Machine Learning · Computer Science 2025-08-06 Yubo Wang , Shimin Di , Zhili Wang , Haoyang Li , Fei Teng , Hao Xin , Lei Chen

Knowledge graph embedding (KGE) that maps entities and relations into vector representations is essential for downstream applications. Conventional KGE methods require high-dimensional representations to learn the complex structure of…

Machine Learning · Computer Science 2024-09-04 Borui Cai , Yong Xiang , Longxiang Gao , Di Wu , He Zhang , Jiong Jin , Tom Luan
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