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Multivariate linear mixed models (mvLMMs) have been widely used in many areas of genetics, and have attracted considerable recent interest in genome-wide association studies (GWASs). However, fitting mvLMMs is computationally non-trivial,…

Quantitative Methods · Quantitative Biology 2013-09-13 Xiang Zhou , Matthew Stephens

Gaussian Mixture Models (GMMs) range among the most frequently used models in machine learning. However, training large, general GMMs becomes computationally prohibitive for datasets that have many data points $N$ of high-dimensionality…

Machine Learning · Statistics 2025-12-12 Sebastian Salwig , Till Kahlke , Florian Hirschberger , Dennis Forster , Jörg Lücke

Over the last decades, the challenges in applied regression and in predictive modeling have been changing considerably: (1) More flexible model specifications are needed as big(ger) data become available, facilitated by more powerful…

Computation · Statistics 2025-10-07 Nikolaus Umlauf , Nadja Klein , Thorsten Simon , Achim Zeileis

Background: Current nomogram can only be created for regression algorithm. Providing nomogram for any machine learning (ML) algorithms may accelerate model deployment in clinical settings or improve model availability. We developed an R…

Machine Learning · Computer Science 2025-01-13 Herdiantri Sufriyana , Emily Chia-Yu Su

Researchers would often like to leverage data from a collection of sources (e.g., primary studies in a meta-analysis) to estimate causal effects in a target population of interest. However, traditional meta-analytic methods do not produce…

Methodology · Statistics 2025-05-15 Guanbo Wang , Sean McGrath , Yi Lian

The EM algorithm is a popular tool for maximum likelihood estimation but has not been used much for high-dimensional regularization problems in linear mixed-effects models. In this paper, we introduce the EMLMLasso algorithm, which combines…

Methodology · Statistics 2023-08-04 Daniela C. R. Oliveira , Fernanda L. Schumacher , Victor H. Lachos

We present a method to integrate Large Language Models (LLMs) and traditional tabular data classification techniques, addressing LLMs challenges like data serialization sensitivity and biases. We introduce two strategies utilizing LLMs for…

Machine Learning · Computer Science 2023-11-21 Max Zhu , Siniša Stanivuk , Andrija Petrovic , Mladen Nikolic , Pietro Lio

Latent factor models that integrate data from multiple sources/studies or modalities have garnered considerable attention across various disciplines. However, existing methods predominantly focus either on multi-study integration or…

Methodology · Statistics 2025-07-15 Wei Liu , Qingzhi Zhong

In Generalized Linear Models (GLMs) it is assumed that there is a linear effect of the predictor variables on the outcome. However, this assumption is often too strict, because in many applications predictors have a nonlinear relation with…

Methodology · Statistics 2023-09-04 S. J. W. Willems , A. J. van der Kooij , J. J. Meulman

A connection between the General Linear Model (GLM) in combination with classical statistical inference and the machine learning (MLE)-based inference is described in this paper. Firstly, the estimation of the GLM parameters is expressed as…

Machine Learning · Statistics 2022-02-10 Juan Manuel Gorriz , SIPBA group , John Suckling

This paper presents a simulation study comparing the performance of generalized joint regression models (GJRM) with generalized linear mixed models (GLMM) and generalized estimating equations (GEE) for regression of longitudinal data with…

Methodology · Statistics 2025-11-07 Aydin Sareff-Hibbert , Gillian Z. Heller

Generalised planning (GP) refers to the task of synthesising programs that solve families of related planning problems. We introduce a novel, yet simple method for GP: given a set of training problems, for each problem, compute an optimal…

Artificial Intelligence · Computer Science 2025-11-17 Dillon Z. Chen , Till Hofmann , Toryn Q. Klassen , Sheila A. McIlraith

We show herein that a pattern based on FGLM techniques can be used for computing Gr\"obner bases, or related structures, associated to linear codes. This Gr\"obner bases setting turns out to be strongly related to the combinatorics of the…

Commutative Algebra · Mathematics 2007-05-23 M. Borges-Quintana , M. A. Borges-Trenard , E. Martinez-Moro

The composite likelihood (CL) is amongst the computational methods used for estimation of the generalized linear mixed model (GLMM) in the context of bivariate meta-analysis of diagnostic test accuracy studies. Its advantage is that the…

Methodology · Statistics 2018-07-12 Aristidis K. Nikoloulopoulos

Generalized autoregressive score (GAS) models are a class of observation-driven time series models that employ the score to dynamically update time-varying parameters of the underlying probability distribution. GAS models have been…

Computation · Statistics 2024-05-09 Vladimír Holý

We describe the R package EstemPMM, which implements the Polynomial Maximization Method (PMM) for parameter estimation under non-Gaussian errors. PMM exploits higher-order cumulants of the error distribution -- specifically the third…

Methodology · Statistics 2026-05-05 Serhii Zabolotnii

The generalized linear model (GLM) plays a key role in regression analyses. In high-dimensional data, the sparse GLM has been used but it is not robust against outliers. Recently, the robust methods have been proposed for the specific…

Machine Learning · Statistics 2026-05-15 Takayuki Kawashima , Hironori Fujisawa

Clustering of longitudinal data is used to explore common trends among subjects over time for a numeric measurement of interest. Various R packages have been introduced throughout the years for identifying clusters of longitudinal patterns,…

Machine Learning · Computer Science 2024-02-23 Niek Den Teuling , Steffen Pauws , Edwin van den Heuvel

Foundation models update slowly due to resource-intensive training, whereas domain-specific models evolve rapidly between releases. Model merging seeks to combine multiple expert models into a single, more capable model, reducing storage…

Artificial Intelligence · Computer Science 2026-03-04 Yongxian Wei , Runxi Cheng , Weike Jin , Enneng Yang , Li Shen , Lu Hou , Sinan Du , Chun Yuan , Xiaochun Cao , Dacheng Tao

Generalized linear models (GLMs) arise in high-dimensional machine learning, statistics, communications and signal processing. In this paper we analyze GLMs when the data matrix is random, as relevant in problems such as compressed sensing,…

Information Theory · Computer Science 2019-04-01 Jean Barbier , Florent Krzakala , Nicolas Macris , Léo Miolane , Lenka Zdeborová