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We analyze a class of network motifs in which a short, two-node positive feed- back motif is inserted in a three-node negative feedback loop. We demonstrate that such networks can undergo a bifurcation to a state where a stable fixed point…

Molecular Networks · Quantitative Biology 2012-09-10 Weihan Li , Sandeep Krishna , Simone Pigolotti , Namiko Mitarai , Mogens H. Jensen

In oscillatory reaction-diffusion systems, time-delay feedback can lead to the instability of uniform oscillations with respect to formation of standing waves. Here, we investigate how the presence of additive, Gaussian white noise can…

Statistical Mechanics · Physics 2016-08-17 Michael Stich , Amit K Chattopadhyay

In weakly nonlinear dispersive wave systems, long-time dynamics are typically governed by time resonances, where wave phases evolve coherently due to exact frequency matching. Recent advances in spatio-temporal spectrum measurements,…

Pattern Formation and Solitons · Physics 2025-12-09 Michal Shavit , Fabio Pusateri , Zhou Zhang , Yulin Pan , Davide Maestrini , Miguel Onorato , Jalal Shatah

The cyanobacterium Synechococcus elongatus uses both a protein phosphorylation cycle and a transcription-translation cycle to generate circadian rhythms that are highly robust against biochemical noise. We use stochastic simulations to…

Molecular Networks · Quantitative Biology 2012-02-16 David Zwicker , David K. Lubensky , Pieter Rein ten Wolde

We demonstrate that strongly asymmetric limit cycles can be observed in the system of three identical ring oscillators (3-gene networks known as Repressilators) globally coupled by signal molecule diffusion added to the model in a way like…

Adaptation and Self-Organizing Systems · Physics 2022-11-18 N. Stankevich , E. Volkov

Bioreactors are widely used in many industries to generate a range of products using various host cells e.g., yeast, insect, and mammalian cells. Depending on the process, product, and host cell, some bioreactors exhibit sustained periodic…

Quantitative Methods · Quantitative Biology 2023-06-29 Pavan Inguva , Krystian Ganko , Alexis B. Dubs , Richard D. Braatz

DNA methylation is a primary layer of epigenetic modification that plays a pivotal role in the regulation of development, aging, and cancer. The concurrent activity of opposing enzymes that mediate DNA methylation and demethylation gives…

Biological Physics · Physics 2026-02-10 Fabrizio Olmeda , Misha Gupta , Onurcan Bektas , Steffen Rulands

We study theoretically the nonstationary circuit QED system in which the artificial atom transition frequency, or the atom-cavity coupling, have a small periodic time modulation, prescribed externally. The system formed by the atom coupled…

Quantum Physics · Physics 2009-06-17 A. V. Dodonov

Reaction-diffusion equations are widely used as the governing evolution equations for modeling many physical, chemical, and biological processes. Here we derive reaction-diffusion equations to model transport with reactions on a…

Statistical Mechanics · Physics 2020-09-16 E. Abad , C. N. Angstmann , B. I. Henry , A. V. McGann , F. Le Vot , S. B. Yuste

We propose a new mechanism for pattern formation based on the global alternation of two dynamics neither of which exhibits patterns. When driven by either one of the separate dynamics, the system goes to a spatially homogeneous state…

Statistical Mechanics · Physics 2009-11-07 J. Buceta , Katja Lindenberg , J. M. R. Parrondo

We study a system of phase oscillators with nonlocal coupling in a ring that supports self-organized patterns of coherence and incoherence, called chimera states. Introducing a global feedback loop, connecting the phase lag to the order…

Chaotic Dynamics · Physics 2015-08-03 Matthias Wolfrum , Oleh Omel'chenko , Jan Sieber

Biological oscillators are very diverse but can be classified based on dynamical motifs such as the types of feedback loops present. The S. Elongatus circadian clock is a remarkable phosphorylation-based oscillator that can be reconstituted…

Molecular Networks · Quantitative Biology 2018-06-06 Alexander D. Golden , Joris Paijmans , David K. Lubensky

Biological systems are majorly dependent on their property of bistability in order to exhibit nongenetic heterogeneity in terms of cellular morphology and physiology. Spatial patterns of phenotypically heterogeneous cells, arising due to…

Quantitative Methods · Quantitative Biology 2023-01-25 Priya Chakraborty , Ushasi Roy , Mohit K. Jolly , Sayantari Ghosh

Spatiotemporal chaos in the form of defect-mediated turbulence is known for oscillators coupled by diffusion. Here we explore the same conditions that produce defect turbulence, in an array of oscillators that are coupled through the…

Chaotic Dynamics · Physics 2018-09-27 Igal Berenstein

We analyze the origin and properties of the chaotic dynamics of two atomic ensembles in a driven-dissipative experimental setup, where they are collectively damped by a bad cavity mode and incoherently pumped by a Raman laser. Starting from…

Chaotic Dynamics · Physics 2020-10-06 Aniket Patra , Boris L. Altshuler , Emil A. Yuzbashyan

Rotating spiral waves with a central core composed of phase-randomized oscillators can arise in reaction-diffusion systems if some of the chemical components involved are diffusion-free. This peculiar phenomenon is demonstrated for a…

Pattern Formation and Solitons · Physics 2009-11-10 Shin-ichiro Shima , Yoshiki Kuramoto

A novel mechanism of reaction-induced active molecular motion, not involving any kind of self-propulsion, is proposed and analyzed. Because of the momentum exchange with the surrounding solvent, conformational transitions in…

Soft Condensed Matter · Physics 2023-04-19 Hiroyuki Kitahata , Alexander S. Mikhailov

Propagation of solitary waves in the presence of autocatalysis, diffusion, and symmetry breaking (differential) advection, is being studied. The focus is on drifting (propagating with advection) pulses that form via a convective instability…

Pattern Formation and Solitons · Physics 2010-02-08 Arik Yochelis , Moshe Sheintuch

We consider the motion of a particle in a periodic two dimensional flow perturbed by small (molecular) diffusion. The flow is generated by a divergence free zero mean vector field. The long time behavior corresponds to the behavior of the…

Probability · Mathematics 2009-03-04 L. Koralov

A molecule traveling in a realistic propagation environment can experience stochastic interactions with other molecules and the environment boundary. The statistical behavior of some isolated phenomena, such as dilute unbounded molecular…

Chemical Physics · Physics 2015-05-20 Adam Noel , Karen C. Cheung , Robert Schober