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Machine learning has significantly advanced healthcare by aiding in disease prevention and treatment identification. However, accessing patient data can be challenging due to privacy concerns and strict regulations. Generating synthetic,…

The scarcity of well-annotated diverse medical images is a major hurdle for developing reliable AI models in healthcare. Substantial technical advances have been made in generative foundation models for natural images. Here we develop…

Computer Vision and Pattern Recognition · Computer Science 2025-09-05 Yuanfeng Ji , Dan Lin , Xiyue Wang , Lu Zhang , Wenhui Zhou , Chongjian Ge , Ruihang Chu , Xiaoli Yang , Junhan Zhao , Junsong Chen , Xiangde Luo , Sen Yang , Jin Fang , Ping Luo , Ruijiang Li

The availability of large-scale chest X-ray datasets is a requirement for developing well-performing deep learning-based algorithms in thoracic abnormality detection and classification. However, biometric identifiers in chest radiographs…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Kai Packhäuser , Lukas Folle , Florian Thamm , Andreas Maier

This work introduces a new latent diffusion model to generate high-quality 3D chest CT scans conditioned on 3D anatomical masks. The method synthesizes volumetric images of size 256x256x256 at 1 mm isotropic resolution using a single…

Computer Vision and Pattern Recognition · Computer Science 2025-10-22 Anna Oliveras , Roger Marí , Rafael Redondo , Oriol Guardià , Ana Tost , Bhalaji Nagarajan , Carolina Migliorelli , Vicent Ribas , Petia Radeva

Purpose: To explore best-practice approaches for generating synthetic chest X-ray images and augmenting medical imaging datasets to optimize the performance of deep learning models in downstream tasks like classification and segmentation.…

Latent Diffusion Models have shown remarkable results in text-guided image synthesis in recent years. In the domain of natural (RGB) images, recent works have shown that such models can be adapted to various vision-language downstream tasks…

Computer Vision and Pattern Recognition · Computer Science 2025-06-13 Konstantinos Vilouras , Ilias Stogiannidis , Junyu Yan , Alison Q. O'Neil , Sotirios A. Tsaftaris

Chest x-rays are a vital tool in the workup of many patients. Similar to most medical imaging modalities, they are profoundly multi-modal and are capable of visualising a variety of combinations of conditions. There is an ever pressing need…

Image and Video Processing · Electrical Eng. & Systems 2021-06-08 Bradley Segal , David M. Rubin , Grace Rubin , Adam Pantanowitz

Text-to-image generation has important implications for generation of diverse and controllable images. Several attempts have been made to adapt Stable Diffusion (SD) to the medical domain. However, the large distribution difference between…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Peng Huang , Xue Gao , Lihong Huang , Jing Jiao , Xiaokang Li , Yuanyuan Wang , Yi Guo

Chest X-ray (CXR) is an important diagnostic tool widely used in hospitals to assess patient conditions and monitor changes over time. Recently, generative models, specifically diffusion-based models, have shown promise in generating…

Image and Video Processing · Electrical Eng. & Systems 2025-05-07 Daeun Kyung , Junu Kim , Tackeun Kim , Edward Choi

Deep learning-based automated diagnosis of lung cancer has emerged as a crucial advancement that enables healthcare professionals to detect and initiate treatment earlier. However, these models require extensive training datasets with…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Aryan Goyal , Ashish Mittal , Pranav Rao , Manoj Tadepalli , Preetham Putha

In this paper, we explore the feasibility of using generative models, specifically Progressive Growing GANs (PG-GANs) and Stable Diffusion fine-tuning, to generate synthetic chest X-ray images for medical diagnosis purposes. Due to ethical…

Image and Video Processing · Electrical Eng. & Systems 2023-05-31 Muhammad Danyal Malik , Danish Humair

Large-scale generative models have demonstrated impressive capabilities in producing visually compelling images, with increasing applications in medical imaging. However, they continue to grapple with hallucination challenges and the…

Image and Video Processing · Electrical Eng. & Systems 2024-10-24 Anees Ur Rehman Hashmi , Ibrahim Almakky , Mohammad Areeb Qazi , Santosh Sanjeev , Vijay Ram Papineni , Jagalpathy Jagdish , Mohammad Yaqub

We propose a cascaded 3D diffusion model framework to synthesize high-fidelity 3D PET/CT volumes directly from demographic variables, addressing the growing need for realistic digital twins in oncologic imaging, virtual trials, and…

Image and Video Processing · Electrical Eng. & Systems 2025-05-29 Siyeop Yoon , Sifan Song , Pengfei Jin , Matthew Tivnan , Yujin Oh , Sekeun Kim , Dufan Wu , Xiang Li , Quanzheng Li

Multimodal models trained on large natural image-text pair datasets have exhibited astounding abilities in generating high-quality images. Medical imaging data is fundamentally different to natural images, and the language used to…

Medical image synthesis plays a crucial role in clinical workflows, addressing the common issue of missing imaging modalities due to factors such as extended scan times, scan corruption, artifacts, patient motion, and intolerance to…

Image and Video Processing · Electrical Eng. & Systems 2025-07-23 Xiaojiao Xiao , Qinmin Vivian Hu , Guanghui Wang

Anatomy shape modeling is a fundamental problem in medical data analysis. However, the geometric complexity and topological variability of anatomical structures pose significant challenges to accurate anatomical shape generation. In this…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Guoqing Zhang , Jingyun Yang , Siqi Chen , Anping Zhang , Yang Li

We present a one-shot text-to-image diffusion model that can generate high-resolution images from natural language descriptions. Our model employs a layered U-Net architecture that simultaneously synthesizes images at multiple resolution…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Emaad Khwaja , Abdullah Rashwan , Ting Chen , Oliver Wang , Suraj Kothawade , Yeqing Li

Despite recent progress, medical foundation models still struggle to unify visual understanding and generation, as these tasks have inherently conflicting goals: semantic abstraction versus pixel-level reconstruction. Existing approaches,…

Computer Vision and Pattern Recognition · Computer Science 2026-01-19 Ruiheng Zhang , Jingfeng Yao , Huangxuan Zhao , Hao Yan , Xiao He , Lei Chen , Zhou Wei , Yong Luo , Zengmao Wang , Lefei Zhang , Dacheng Tao , Bo Du

The development of successful artificial intelligence models for chest X-ray analysis relies on large, diverse datasets with high-quality annotations. While several databases of chest X-ray images have been released, most include disease…

Image and Video Processing · Electrical Eng. & Systems 2024-05-21 Nicolás Gaggion , Candelaria Mosquera , Lucas Mansilla , Julia Mariel Saidman , Martina Aineseder , Diego H. Milone , Enzo Ferrante

We introduce CheXGenBench, a rigorous and multifaceted evaluation framework for synthetic chest radiograph generation that simultaneously assesses fidelity, privacy risks, and clinical utility across state-of-the-art text-to-image…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Raman Dutt , Pedro Sanchez , Yongchen Yao , Steven McDonagh , Sotirios A. Tsaftaris , Timothy Hospedales
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