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Deep learning has revolutionized medical image segmentation, but it relies heavily on high-quality annotations. The time, cost and expertise required to label images at the pixel-level for each new task has slowed down widespread adoption…

Computer Vision and Pattern Recognition · Computer Science 2024-07-31 Maxime Seince , Loic Le Folgoc , Luiz Augusto Facury de Souza , Elsa Angelini

Hematoxylin and Eosin (H&E) staining of whole slide images (WSIs) is considered the gold standard for pathologists and medical practitioners for tumor diagnosis, surgical planning, and post-operative assessment. With the rapid advancement…

Computer Vision and Pattern Recognition · Computer Science 2024-11-08 Liangrui Pan , Mao Huang , Lian Wang , Pinle Qin , Shaoliang Peng

Whole Slide Images (WSIs) are giga-pixel in scale and are typically partitioned into small instances in WSI classification pipelines for computational feasibility. However, obtaining extensive instance level annotations is costly, making…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Jayanie Bogahawatte , Sachith Seneviratne , Saman Halgamuge

Delineation of cancerous regions in gigapixel whole slide images (WSIs) is a crucial diagnostic procedure in digital pathology. This process is time-consuming because of the large search space in the gigapixel WSIs, causing chances of…

Image and Video Processing · Electrical Eng. & Systems 2020-07-21 Hsien-Tzu Cheng , Chun-Fu Yeh , Po-Chen Kuo , Andy Wei , Keng-Chi Liu , Mong-Chi Ko , Kuan-Hua Chao , Yu-Ching Peng , Tyng-Luh Liu

Despite the success of deep learning based models in medical image segmentation, most state-of-the-art (SOTA) methods perform fully-supervised learning, which commonly rely on large scale annotated training datasets. However, medical image…

Computer Vision and Pattern Recognition · Computer Science 2025-12-15 Zhendi Gong , Xin Chen

Whole Slide Images (WSIs) or histopathology images are used in digital pathology. WSIs pose great challenges to deep learning models for clinical diagnosis, owing to their size and lack of pixel-level annotations. With the recent…

Computer Vision and Pattern Recognition · Computer Science 2024-02-14 Soham Rohit Chitnis , Sidong Liu , Tirtharaj Dash , Tanmay Tulsidas Verlekar , Antonio Di Ieva , Shlomo Berkovsky , Lovekesh Vig , Ashwin Srinivasan

Whole slide images (WSIs) are gigapixel-scale digital images of H\&E-stained tissue samples widely used in pathology. The substantial size and complexity of WSIs pose unique analytical challenges. Multiple Instance Learning (MIL) has…

Computer Vision and Pattern Recognition · Computer Science 2024-08-20 Jun Wang , Yu Mao , Nan Guan , Chun Jason Xue

Pathology whole-slide images (WSIs) are widely used for cancer survival analysis because of their comprehensive histopathological information at both cellular and tissue levels, enabling quantitative, large-scale, and prognostically rich…

Image and Video Processing · Electrical Eng. & Systems 2025-10-02 Yucheng Xing , Ling Huang , Jingying Ma , Ruping Hong , Jiangdong Qiu , Pei Liu , Kai He , Huazhu Fu , Mengling Feng

In the era of information explosion, efficiently leveraging large-scale unlabeled data while minimizing the reliance on high-quality pixel-level annotations remains a critical challenge in the field of medical imaging. Semi-supervised…

Computer Vision and Pattern Recognition · Computer Science 2025-06-11 Hongjie Zhu , Xiwei Liu , Rundong Xue , Zeyu Zhang , Yong Xu , Daji Ergu , Ying Cai , Yang Zhao

Biomedical image segmentation plays a significant role in computer-aided diagnosis. However, existing CNN based methods rely heavily on massive manual annotations, which are very expensive and require huge human resources. In this work, we…

Computer Vision and Pattern Recognition · Computer Science 2023-01-13 Ruifei Zhang , Sishuo Liu , Yizhou Yu , Guanbin Li

Accurate identification of breast masses is crucial in diagnosing breast cancer; however, it can be challenging due to their small size and being camouflaged in surrounding normal glands. Worse still, it is also expensive in clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Xinyu Xiong , Churan Wang , Wenxue Li , Guanbin Li

A key requirement for the success of supervised deep learning is a large labeled dataset - a condition that is difficult to meet in medical image analysis. Self-supervised learning (SSL) can help in this regard by providing a strategy to…

Computer Vision and Pattern Recognition · Computer Science 2020-11-02 Krishna Chaitanya , Ertunc Erdil , Neerav Karani , Ender Konukoglu

While Multiple Instance Learning (MIL) has shown promising results in digital Pathology Whole Slide Image (WSI) classification, such a paradigm still faces performance and generalization problems due to challenges in high computational…

Computer Vision and Pattern Recognition · Computer Science 2023-03-16 Honglin Li , Chenglu Zhu , Yunlong Zhang , Yuxuan Sun , Zhongyi Shui , Wenwei Kuang , Sunyi Zheng , Lin Yang

Semi-supervised learning (SSL) aims to help reduce the cost of the manual labelling process by leveraging a substantial pool of unlabelled data alongside a limited set of labelled data during the training phase. Since pixel-level manual…

Computer Vision and Pattern Recognition · Computer Science 2025-05-26 Wanli Ma , Oktay Karakus , Paul L. Rosin

Self-supervised learning (SSL) has emerged as a powerful paradigm for medical image representation learning, particularly in settings with limited labeled data. However, existing SSL methods often rely on complex architectures,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Azad Singh , Deepak Mishra

Task-specific deep learning models in histopathology offer promising opportunities for improving diagnosis, clinical research, and precision medicine. However, development of such models is often limited by availability of high-quality…

We propose a segmentation framework that uses deep neural networks and introduce two innovations. First, we describe a biophysics-based domain adaptation method. Second, we propose an automatic method to segment white and gray matter, and…

Computer Vision and Pattern Recognition · Computer Science 2018-10-16 Amir Gholami , Shashank Subramanian , Varun Shenoy , Naveen Himthani , Xiangyu Yue , Sicheng Zhao , Peter Jin , George Biros , Kurt Keutzer

We propose a Deep learning-based weak label learning method for analyzing whole slide images (WSIs) of Hematoxylin and Eosin (H&E) stained tumor tissue not requiring pixel-level or tile-level annotations using Self-supervised pre-training…

Image and Video Processing · Electrical Eng. & Systems 2023-06-29 Yoni Schirris , Efstratios Gavves , Iris Nederlof , Hugo Mark Horlings , Jonas Teuwen

For brain tumour segmentation, deep learning models can achieve human expert-level performance given a large amount of data and pixel-level annotations. However, the expensive exercise of obtaining pixel-level annotations for large amounts…

Computer Vision and Pattern Recognition · Computer Science 2023-10-11 Xiao Liu , Antanas Kascenas , Hannah Watson , Sotirios A. Tsaftaris , Alison Q. O'Neil

Breast cancer is one of the leading causes of female mortality in the world. This can be reduced when diagnoses are performed at the early stages of progression. Further, the efficiency of the process can be significantly improved with…

Image and Video Processing · Electrical Eng. & Systems 2022-02-15 Aravind Ravi