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Model interpretability has become an important problem in machine learning (ML) due to the increased effect that algorithmic decisions have on humans. Counterfactual explanations can help users understand not only why ML models make certain…

Machine Learning · Computer Science 2021-12-20 Ana Lucic , Harrie Oosterhuis , Hinda Haned , Maarten de Rijke

Counterfactual reasoning, a cornerstone of human cognition and decision-making, is often seen as the 'holy grail' of causal learning, with applications ranging from interpreting machine learning models to promoting algorithmic fairness.…

Machine Learning · Computer Science 2025-04-11 Yahya Aalaila , Gerrit Großmann , Sumantrak Mukherjee , Jonas Wahl , Sebastian Vollmer

Negative controls are increasingly used to evaluate the presence of potential unmeasured confounding in observational studies. Beyond the use of negative controls to detect the presence of residual confounding, proximal causal inference…

Methodology · Statistics 2024-06-06 Jiewen Liu , Chan Park , Kendrick Li , Eric J. Tchetgen Tchetgen

Estimating long-term causal effects by combining long-term observational and short-term experimental data is a crucial but challenging problem in many real-world scenarios. In existing methods, several ideal assumptions, e.g. latent…

Machine Learning · Computer Science 2025-05-12 Ruichu Cai , Junjie Wan , Weilin Chen , Zeqin Yang , Zijian Li , Peng Zhen , Jiecheng Guo

Algorithms are commonly used to predict outcomes under a particular decision or intervention, such as predicting whether an offender will succeed on parole if placed under minimal supervision. Generally, to learn such counterfactual…

Machine Learning · Statistics 2021-04-19 Amanda Coston , Edward H. Kennedy , Alexandra Chouldechova

We present methods for causally interpretable meta-analyses that combine information from multiple randomized trials to estimate potential (counterfactual) outcome means and average treatment effects in a target population. We consider…

Causal inference quantifies cause-effect relationships by estimating counterfactual parameters from data. This entails using \emph{identification theory} to establish a link between counterfactual parameters of interest and distributions…

Machine Learning · Statistics 2020-04-17 Jaron J. R. Lee , Ilya Shpitser

This paper clarifies how and why structural demand models (Berry and Haile, 2014, 2024) predict unit-level counterfactual outcomes. We do so by casting structural assumptions equivalently as restrictions on the joint distribution of…

Econometrics · Economics 2025-11-07 Jiafeng Chen

Political scientists are increasingly interested in assessing causal mechanisms, or determining not just if a causal effect exists but also why it occurs. Even so, many researchers avoid formal causal mediation analyses due to their…

Applications · Statistics 2024-11-21 Matthew Blackwell , Ruofan Ma , Aleksei Opacic

Recent work by Chatzi et al. and Ravfogel et al. has developed, for the first time, a method for generating counterfactuals of probabilistic Large Language Models. Such counterfactuals tell us what would - or might - have been the output of…

Artificial Intelligence · Computer Science 2026-04-21 Sander Beckers

Transparency is a fundamental requirement for decision making systems when these should be deployed in the real world. It is usually achieved by providing explanations of the system's behavior. A prominent and intuitive type of explanations…

Machine Learning · Computer Science 2021-07-23 André Artelt , Valerie Vaquet , Riza Velioglu , Fabian Hinder , Johannes Brinkrolf , Malte Schilling , Barbara Hammer

With the evolution of single-cell RNA sequencing techniques into a standard approach in genomics, it has become possible to conduct cohort-level causal inferences based on single-cell-level measurements. However, the individual gene…

Methodology · Statistics 2025-04-23 Jin-Hong Du , Zhenghao Zeng , Edward H. Kennedy , Larry Wasserman , Kathryn Roeder

Machine learning can impact people with legal or ethical consequences when it is used to automate decisions in areas such as insurance, lending, hiring, and predictive policing. In many of these scenarios, previous decisions have been made…

Machine Learning · Statistics 2018-03-09 Matt J. Kusner , Joshua R. Loftus , Chris Russell , Ricardo Silva

Recent proposal for counterfactual computation [Hosten et al., Nature, 439, 949 (2006)] is analyzed. It is argued that the method does not provide counterfactual computation for all possible outcomes. The explanation involves a novel…

Quantum Physics · Physics 2015-06-26 Lev Vaidman

Unobserved confounding is a central barrier to drawing causal inferences from observational data. Several authors have recently proposed that this barrier can be overcome in the case where one attempts to infer the effects of several…

Machine Learning · Statistics 2019-03-20 Alexander D'Amour

Counterfactuals operationalised through algorithmic recourse have become a powerful tool to make artificial intelligence systems explainable. Conceptually, given an individual classified as y -- the factual -- we seek actions such that…

Instrumental variable (IV) methods play a central role in causal inference, particularly in settings where treatment assignment is confounded by unobserved variables. IV methods have been extensively developed in recent years and applied…

Applied researchers in biomedicine and related fields are often interested in estimating the causal effect of a treatment or intervention. Although randomized clinical trials are considered the gold standard for establishing causal effects,…

Counterfactuals are widely used to explain ML model predictions by providing alternative scenarios for obtaining the more desired predictions. They can be generated by a variety of methods that optimize different, sometimes conflicting,…

Machine Learning · Computer Science 2024-08-05 Ignacy Stępka , Mateusz Lango , Jerzy Stefanowski

Causal effects are usually studied in terms of the means of counterfactual distributions, which may be insufficient in many scenarios. Given a class of densities known up to normalizing constants, we propose to model counterfactual…

Methodology · Statistics 2024-02-20 Diego Martinez-Taboada , Edward H. Kennedy
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