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Cluster analysis is an unsupervised learning strategy that can be employed to identify subgroups of observations in data sets of unknown structure. This strategy is particularly useful for analyzing high-dimensional data such as microarray…

Methodology · Statistics 2016-10-07 Erika S. Helgeson , Eric Bair

Flow-based deep generative models learn data distributions by transforming a simple base distribution into a complex distribution via a set of invertible transformations. Due to the invertibility, such models can score unseen data samples…

Machine Learning · Computer Science 2019-06-18 Maximilian Schmidt , Marko Simic

Change detection typically involves identifying regions with changes between bitemporal images taken at the same location. Besides significant changes, slow changes in bitemporal images are also important in real-life scenarios. For…

Computer Vision and Pattern Recognition · Computer Science 2025-07-04 Haoxuan Li , Chenxu Wei , Haodong Wang , Xiaomeng Hu , Boyuan An , Lingyan Ran , Baosen Zhang , Jin Jin , Omirzhan Taukebayev , Amirkhan Temirbayev , Junrui Liu , Xiuwei Zhang

Coarse-grained (CG) molecular simulations have become a standard tool to study molecular processes on time- and length-scales inaccessible to all-atom simulations. Parameterizing CG force fields to match all-atom simulations has mainly…

Computational Physics · Physics 2023-02-07 Jonas Köhler , Yaoyi Chen , Andreas Krämer , Cecilia Clementi , Frank Noé

Microfluidic devices offer numerous advantages in medical applications, including the capture of single cells in microwell-based platforms for genomic analysis. As the cost of sequencing decreases, the demand for high-throughput single-cell…

Computational Engineering, Finance, and Science · Computer Science 2024-09-13 Xueying Zhao , Yan Chen , Yuefu Jiang , Amie Radenbaugh , Jamie Moskwa , Devon Jensen

The expression levels of many thousands of genes can be measured simultaneously by DNA microarrays (chips). This novel experimental tool has revolutionized research in molecular biology and generated considerable excitement. A typical…

Biological Physics · Physics 2007-05-23 Eytan Domany

The performance of optical flow algorithms greatly depends on the specifics of the content and the application for which it is used. Existing and well established optical flow datasets are limited to rather particular contents from which…

Computer Vision and Pattern Recognition · Computer Science 2018-11-20 Gregory Schröder , Tobias Senst , Erik Bochinski , Thomas Sikora

Network management and security is currently one of the most vibrant research areas, among which, research on detecting and identifying anomalies has attracted a lot of interest. Researchers are still struggling to find an effective and…

Networking and Internet Architecture · Computer Science 2010-07-09 Huy Nguyen , Tam Van Nguyen , Dong Il Kim , Deokjai Choi

We demonstrate novel instrumentation for spontaneous Raman spectroscopy in biofluids, enabling development of a portable, automated, reliable diagnostics technique requiring minimal operator expertise to quantify disease markers. Label-free…

Biological Physics · Physics 2021-05-27 Emily E. Storey , Duxuan Wu , Amr S. Helmy

Feature identification is an important task in many fluid dynamics applications and diverse methods have been developed for this purpose. These methods are based on a physical understanding of the underlying behavior of the flow in the…

Fluid Dynamics · Physics 2019-01-07 Carlos Michelén Ströfer , Jinlong Wu , Heng Xiao , Eric Paterson

Research into mechanisms of hematogenous metastasis has largely become genetic in focus, attempting to understand the molecular basis of `seed-soil' relationships. Preceeding this biological mechanism is the physical process of…

Tissues and Organs · Quantitative Biology 2013-09-20 Jacob G. Scott , Alexander G. Fletcher , Philip K. Maini , Alexander R. A. Anderson , Philip Gerlee

We combine confocal imaging, microfluidics and image analysis to record 3D-images of cells in flow. This enables us to recover the full 3D representation of several hundred living cells per minute. Whereas 3D confocal imaging has thus far…

Fluid Dynamics · Physics 2017-09-19 S. Quint , A. F. Christ , A. Guckenberger , S. Himbert , L. Kaestner , S. Gekle , C. Wagner

In today's data-driven digital era, the amount as well as complexity, such as multi-view, non-Euclidean, and multi-relational, of the collected data are growing exponentially or even faster. Clustering, which unsupervisely extracts valid…

Machine Learning · Computer Science 2025-01-10 Zhao Kang , Xuanting Xie , Bingheng Li , Erlin Pan

Diffuse Reflectance Spectroscopy has demonstrated a strong aptitude for identifying and differentiating biological tissues. However, the broadband and smooth nature of these signals require algorithmic processing, as they are often…

Image and Video Processing · Electrical Eng. & Systems 2025-03-06 Nicola Rossberg , Celina L. Li , Simone Innocente , Stefan Andersson-Engels , Katarzyna Komolibus , Barry O'Sullivan , Andrea Visentin

Due to recent advances in data collection techniques, massive amounts of data are being collected at an extremely fast pace. Also, these data are potentially unbounded. Boundless streams of data collected from sensors, equipments, and other…

Databases · Computer Science 2012-03-12 T Soni Madhulatha

We formulate a novel technique for the detection of functional clusters in discrete event data. The advantage of this algorithm is that no prior knowledge of the number of functional groups is needed, as our procedure progressively combines…

Neurons and Cognition · Quantitative Biology 2015-05-13 S. Feldt , J. Waddell , V. L. Hetrick , J. D. Berke , M. Zochowski

We propose a machine learning framework based on Flow Matching (FM) to identify critical properties in many-body systems efficiently. Using the 2D XY model as a benchmark, we demonstrate that a single network, trained only on configurations…

Statistical Mechanics · Physics 2026-01-06 Qian-Rui Lee , Daw-Wei Wang

Data flow analysis and optimization is considered for homogeneous rectangular mesh networks. We propose a flow matrix equation which allows a closed-form characterization of the nature of the minimal time solution, speedup and a simple…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-12-30 Junwei Zhang , Yang Liu , Li Shi , Thomas G. Robertazzi

Currently, data-driven discovery in biological sciences resides in finding segmentation strategies in multivariate data that produce sensible descriptions of the data. Clustering is but one of several approaches and sometimes falls short…

Quantitative Methods · Quantitative Biology 2022-08-12 Richard Tjörnhammar

Flow models are a cornerstone of modern machine learning. They are generative models that progressively transform probability distributions according to learned dynamics. Specifically, they learn a continuous-time Markov process that…

Quantum Physics · Physics 2025-10-10 David Layden , Ryan Sweke , Vojtěch Havlíček , Anirban Chowdhury , Kirill Neklyudov