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Stereotactic body radiotherapy (SBRT) is characterized by delivering a high amount of dose in a short period of time. In SBRT the dose is delivered using open fields (e.g., beam's-eye-view) known as "apertures". Mathematical methods can be…
Tuneable retarder arrays, such as spatially patterned liquid crystal devices, have given rise to impressive photonic functionality, fuelling diverse applications ranging from microscopy and holography to encryption and communications.…
The increasing interest in FLASH-RT has lead to the conversion of linear accelerators to enable ultra-high dose rate (UHDR) beams for preclinical research. Dosimetry hereof remains challenging with several crucial aspects missing. This work…
Background and Purpose: Voxel-based analysis (VBA) helps to identify dose-sensitive regions by aligning individual dose distributions within a common coordinate system (CCS). Accurate deformable image registration (DIR) is essential for…
Proton Computed Tomography (pCT) provides a promising solution to enhance the accuracy of Relative Stopping Power (RSP) required for proton therapy planning. This research introduces a novel high-granularity pCT architecture that…
Accurate dose calculation on cone beam computed tomography (CBCT) images is essential for modern proton treatment planning workflows, particularly when accounting for inter-fractional anatomical changes in adaptive treatment scenarios.…
Stereotactic body radiation therapy allows for a precise and accurate dose delivery. Organ motion during treatment bears the risk of undetected high dose healthy tissue exposure. An organ very susceptible to high dose is the oesophagus. Its…
The first purpose of this paper is to shed some new light on the old question of selecting the number of beams in intensity-modulated radiation therapy (IMRT). The second purpose is to illuminate the related issue of discrete static beam…
Predictive dosimetry is central to enabling personalized radiopharmaceutical therapy (RPT), particularly in prostate specific membrane antigen (PSMA) targeted theranostics. In this work, we develop a three layer computational framework that…
Background: Whereas filtered back projection algorithms for voxel-based CT image reconstruction have noise properties defined by the filter, iterative algorithms must stop at some point in their convergence and do not necessarily produce…
We propose a fast beam orientation selection method, based on deep neural networks (DNN), capable of developing a plan comparable to those by the state-of-the-art column generation method. The novelty of Our model lies in its supervised…
Purpose: Beam angle selection is critical in proton therapy treatment planning, yet automated approaches remain underexplored. This study presents and evaluates GAMBAS, a novel, fast machine learning model for automatic beam angle…
Purpose: This study aims to optimize and characterize the response of a mPSD for in vivo dosimetry in HDR brachytherapy. Methods: An exhaustive analysis was carried out in order to obtain an optimized mPSD design that maximize the…
Customization techniques for text-to-image models have paved the way for a wide range of previously unattainable applications, enabling the generation of specific concepts across diverse contexts and styles. While existing methods…
This paper presents the design of a rapid cycling synchrotron (RCS) featuring a longitudinal localized kick driven fast extraction system for three-dimensional (3D) pencil beam scanning (PBS) proton FLASH delivery. The extraction method is…
This paper presents the results of a comprehensive study on the optimization of the optical system for independent amplitude and phase wavefront manipulation, which is based on a digital micromirror device implementation. The parameters of…
Proper X-ray radiation design (via dynamic fluence field modulation, FFM) allows to reduce effective radiation dose in computed tomography without compromising image quality. It takes into account patient anatomy, radiation sensitivity of…
Techniques for preclinical intensity modulated radiation therapy are being developed to improve translation by replicating the clinical paradigm. This study presents the first treatment planning comparison between small animal IMRT…
Radiotherapy is used to treat cancer patients by damaging DNA of tumor cells using ionizing radiation. Photons are the most widely used radiation type for therapy, having been put into use soon after the first discovery of X-rays in 1895.…
Purpose: Commercial UHDR platforms deliver Ultra-High Dose Rate (UHDR) doses at discrete combinations of pulse parameters including pulse width (PW), pulse repetition frequency (PRF) and number of pulses (N), which dictate unique…