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Deformable templates are essential to large-scale medical image registration, segmentation, and population analysis. Current conventional and deep network-based methods for template construction use only regularized registration objectives…

Computer Vision and Pattern Recognition · Computer Science 2022-03-21 Neel Dey , Mengwei Ren , Adrian V. Dalca , Guido Gerig

Deep learning based methods provide efficient solutions to medical image registration, including the challenging problem of diffeomorphic image registration. However, most methods register normal image pairs, facing difficulty handling…

Image and Video Processing · Electrical Eng. & Systems 2023-03-17 Ankita Joshi , Yi Hong

We introduce HyperMorph, a framework that facilitates efficient hyperparameter tuning in learning-based deformable image registration. Classical registration algorithms perform an iterative pair-wise optimization to compute a deformation…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Andrew Hoopes , Malte Hoffmann , Douglas N. Greve , Bruce Fischl , John Guttag , Adrian V. Dalca

Medical image registration is a critical component of clinical imaging workflows, enabling accurate longitudinal assessment, multi-modal data fusion, and image-guided interventions. Intensity-based approaches often struggle with…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Eytan Kats , Mattias P. Heinrich

Nonrigid registration is vital to medical image analysis but remains challenging for diffusion MRI (dMRI) due to its high-dimensional, orientation-dependent nature. While classical methods are accurate, they are computationally demanding,…

Image and Video Processing · Electrical Eng. & Systems 2025-01-13 Gianfranco Cortes , Xiaoda Qu , Baba C. Vemuri

The majority of deep learning (DL) based deformable image registration methods use convolutional neural networks (CNNs) to estimate displacement fields from pairs of moving and fixed images. This, however, requires the convolutional kernels…

Image and Video Processing · Electrical Eng. & Systems 2022-08-02 Yihao Liu , Lianrui Zuo , Shuo Han , Yuan Xue , Jerry L. Prince , Aaron Carass

Image registration is a core task in computational anatomy that establishes correspondences between images. Invertible deformable registration, which computes a deformation field and handles complex, non-linear transformations, is essential…

Computer Vision and Pattern Recognition · Computer Science 2025-07-08 Krithika Iyer , Shireen Elhabian , Sarang Joshi

Image registration is a process of aligning two or more images of same objects using geometric transformation. Most of the existing approaches work on the assumption of location invariance. These approaches require object-centric images to…

Computer Vision and Pattern Recognition · Computer Science 2019-01-14 Deepak Mishra , Rajeev Ranjan , Santanu Chaudhury , Mukul Sarkar , Arvinder Singh Soin

Deep-learning-based registration methods emerged as a fast alternative to conventional registration methods. However, these methods often still cannot achieve the same performance as conventional registration methods because they are either…

Computer Vision and Pattern Recognition · Computer Science 2021-06-15 Alessa Hering , Stephanie Häger , Jan Moltz , Nikolas Lessmann , Stefan Heldmann , Bram van Ginneken

Deformable image registration is a standard engineering problem used to determine the distortion experienced by a body by comparing two images of it in different states. This study introduces two new DIR methods designed to capture…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Daniel E. Hurtado , Axel Osses , Rodrigo Quezada

Deformable image registration (alignment) is highly sought after in numerous clinical applications, such as computer aided diagnosis and disease progression analysis. Deep Convolutional Neural Network (DCNN)-based image registration methods…

Image and Video Processing · Electrical Eng. & Systems 2024-05-17 Ruizhe Li , Grazziela Figueredo , Dorothee Auer , Christian Wagner , Xin Chen

Registration of brain MRI images requires to solve a deformation field, which is extremely difficult in aligning intricate brain tissues, e.g., subcortical nuclei, etc. Existing efforts resort to decomposing the target deformation field…

Image and Video Processing · Electrical Eng. & Systems 2022-04-27 Jinxin Lv , Zhiwei Wang , Hongkuan Shi , Haobo Zhang , Sheng Wang , Yilang Wang , Qiang Li

Recent advances in deep learning-based medical image registration have shown that training deep neural networks~(DNNs) does not necessarily require medical images. Previous work showed that DNNs trained on randomly generated images with…

Computer Vision and Pattern Recognition · Computer Science 2025-06-02 Junyu Chen , Shuwen Wei , Yihao Liu , Aaron Carass , Yong Du

Image registration is a crucial task in signal processing, but it often encounters issues with stability and efficiency. Non-learning registration approaches rely on optimizing similarity metrics between fixed and moving images, which can…

Computer Vision and Pattern Recognition · Computer Science 2023-03-28 Zihao Wang , Hervé Delingette

The recent application of deep learning technologies in medical image registration has exponentially decreased the registration time and gradually increased registration accuracy when compared to their traditional counterparts. Most of the…

Image and Video Processing · Electrical Eng. & Systems 2020-02-19 Abdullah Nazib , Clinton Fookes , Olivier Salvado , Dimitri Perrin

Deep learning has revolutionized image registration by its ability to handle diverse tasks while achieving significant speed advantages over conventional approaches. Current approaches, however, often employ globally uniform smoothness…

Computer Vision and Pattern Recognition · Computer Science 2025-09-22 Xiang Chen , Fengting Zhang , Qinghao Liu , Min Liu , Kun Wu , Yaonan Wang , Hang Zhang

This paper aims to create a deep learning framework that can estimate the deformation vector field (DVF) for directly registering abdominal MRI-CT images. The proposed method assumed a diffeomorphic deformation. By using topology-preserved…

Computer Vision and Pattern Recognition · Computer Science 2024-05-07 Yang Lei , Luke A. Matkovic , Justin Roper , Tonghe Wang , Jun Zhou , Beth Ghavidel , Mark McDonald , Pretesh Patel , Xiaofeng Yang

Multi-contrast image registration is a challenging task due to the complex intensity relationships between different imaging contrasts. Conventional image registration methods are typically based on iterative optimizations for each input…

Computer Vision and Pattern Recognition · Computer Science 2024-08-13 Yinsong Wang , Siyi Du , Shaoming Zheng , Xinzhe Luo , Chen Qin

Accurate registration of medical images is vital for doctor's diagnosis and quantitative analysis. In this paper, we propose a new deformable medical image registration method based on average geometric transformations and VoxelMorph CNN…

Computer Vision and Pattern Recognition · Computer Science 2019-07-24 Yongpei Zhu , Zicong Zhou , Guojun Liao , Kehong Yuan

Deformable medical image registration is a fundamental task in medical image analysis with applications in disease diagnosis, treatment planning, and image-guided interventions. Despite significant advances in deep learning based…

Machine Learning · Computer Science 2026-02-10 Muhammad Zafar Iqbal , Ghazanfar Farooq Siddiqui , Anwar Ul Haq , Imran Razzak