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Near-term quantum computers are expected to work in an environment where each operation is noisy, with no error correction. Therefore, quantum-circuit optimizers are applied to minimize the number of noisy operations. Today, physicists are…

Programming Languages · Computer Science 2023-05-12 Amanda Xu , Abtin Molavi , Lauren Pick , Swamit Tannu , Aws Albarghouthi

Background: A classical problem in metabolic design is to maximize the production of desired compound in a given chemical reaction network by appropriately directing the mass flow through the network. Computationally, this problem is…

Molecular Networks · Quantitative Biology 2011-10-28 Jakob L. Andersen , Christoph Flamm , Daniel Merkle , Peter F. Stadler

This work introduces an integrative approach based on Q-analysis with machine learning. The new approach, called Neural Hypernetwork, has been applied to a case study of pulmonary embolism diagnosis. The objective of the application of…

Quantum adiabatic optimization seeks to solve combinatorial problems using quantum dynamics, requiring the Hamiltonian of the system to align with the problem of interest. However, these Hamiltonians are often incompatible with the native…

Combinatorial optimization on near-term quantum devices is a promising path to demonstrating quantum advantage. However, the capabilities of these devices are constrained by high noise or error rates. In this paper, we propose an iterative…

Quantum Physics · Physics 2022-05-12 Xiaoyuan Liu , Anthony Angone , Ruslan Shaydulin , Ilya Safro , Yuri Alexeev , Lukasz Cincio

In this paper, we propose a quantum computing oriented benchmark for combinatorial optimization. This benchmark, coined as QOPTLib, is composed of 40 instances equally distributed over four well-known problems: Traveling Salesman Problem,…

Quantum Physics · Physics 2024-04-25 Eneko Osaba , Esther Villar-Rodriguez

Quantum approximate optimization algorithm (QAOA) is one of the popular quantum algorithms that are used to solve combinatorial optimization problems via approximations. QAOA is able to be evaluated on both physical and virtual quantum…

Quantum Physics · Physics 2023-12-07 Yu-Cheng Lin , Chuan-Chi Wang , Chia-Heng Tu , Shih-Hao Hung

Nuclear quantum phenomena beyond the Born-Oppenheimer approximation are known to play an important role in a growing number of chemical and biological processes. While there exists no unique consensus on a rigorous and efficient…

Quantum computing is expected to provide exponential speedup in machine learning. However, optimizing the data loading process, commonly referred to as quantum data embedding, to maximize classification performance remains a critical…

This work explores the integration of Quantum Machine Learning (QML) and Quantum-Inspired (QI) techniques for optimizing end-to-end (E2E) network services in telecommunication systems, particularly focusing on 5G networks and beyond. The…

Networking and Internet Architecture · Computer Science 2025-09-03 Fatma Chaouech , Javier Villegas , António Pereira , Carlos Baena , Sergio Fortes , Raquel Barco , Dominic Gribben , Mohammad Dib , Alba Villarino , Aser Cortines , Román Orús

NP-hard problems are not believed to be exactly solvable through general polynomial time algorithms. Hybrid quantum-classical algorithms to address such combinatorial problems have been of great interest in the past few years. Such…

Quantum Physics · Physics 2024-01-15 Yagnik Chatterjee , Eric Bourreau , Marko J. Rančić

The effects of molecularly targeted drug perturbations on cellular activities and fates are difficult to predict using intuition alone because of the complex behaviors of cellular regulatory networks. An approach to overcoming this problem…

Systems and Control · Computer Science 2019-01-15 Afroza Shirin , Isaac Klickstein , Song Feng , Yen Ting Lin , William S. Hlavacek , Francesco Sorrentino

Quantum computation appears to offer significant advantages over classical computation and this has generated a tremendous interest in the field. In this thesis we consider the application of quantum computers to scientific computing and…

Quantum Physics · Physics 2018-05-10 Stuart Hadfield

Quantum-classical Hybrid Machine Learning (QHML) models are recognized for their robust performance and high generalization ability even for relatively small datasets. These qualities offer unique advantages for anti-cancer drug response…

Machine Learning · Computer Science 2025-05-16 Takafumi Ito , Lysenko Artem , Tatsuhiko Tsunoda

Conventional classical solvers are commonly used for solving matrix equation systems resulting from the discretization of SIEs in computational electromagnetics (CEM). However, the memory requirement would become a bottleneck for classical…

Quantum Physics · Physics 2025-12-04 Rui Chen , Teng-Yang Ma , Meng-Han Dou , Chao-Fu Wang

Quantum computing is a computational paradigm with the potential to outperform classical methods for a variety of problems. Proposed recently, the Quantum Approximate Optimization Algorithm (QAOA) is considered as one of the leading…

Machine Learning · Computer Science 2022-06-16 Sami Khairy , Ruslan Shaydulin , Lukasz Cincio , Yuri Alexeev , Prasanna Balaprakash

Recent advances in quantum technologies pave the way for noisy intermediate-scale quantum (NISQ) devices, where quantum approximation optimization algorithms (QAOAs) constitute promising candidates for demonstrating tangible quantum…

Information Theory · Computer Science 2021-07-13 Jingjing Cui , Yifeng Xiong , Soon Xin Ng , Lajos Hanzo

Challenging combinatorial optimization problems are ubiquitous in science and engineering. Several quantum methods for optimization have recently been developed, in different settings including both exact and approximate solvers. Addressing…

Quantum Physics · Physics 2023-09-20 Nicolas PD Sawaya , Albert T Schmitz , Stuart Hadfield

Flux balance analysis has proven an effective tool for analyzing metabolic networks. In flux balance analysis, reaction rates and optimal pathways are ascertained by solving a linear program, in which the growth rate is maximized subject to…

Optimization and Control · Mathematics 2018-04-10 Amir Akbari , Paul I. Barton

Cancer is one of the leading causes of death worldwide. It is caused by a variety of genetic mutations, which makes every instance of the disease unique. Since chemotherapy can have extremely severe side effects, each patient requires a…