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Quantum computing (QC) provides a promising avenue toward enabling quantum chemistry calculations, which are classically impossible due to a computational complexity that increases exponentially with system size. As fully fault-tolerant…

Bayesian network structure learning is an NP-hard problem that has been faced by a number of traditional approaches in recent decades. Currently, quantum technologies offer a wide range of advantages that can be exploited to solve…

Quantum Physics · Physics 2022-03-07 Vicente P. Soloviev , Concha Bielza , Pedro Larrañaga

Molecular docking plays a pivotal role in drug discovery and precision medicine, enabling us to understand protein functions and advance novel therapeutics. Here, we introduce a potential alternative solution to this problem, the…

Quantum Physics · Physics 2024-05-17 Qi-Ming Ding , Yi-Ming Huang , Xiao Yuan

The frequent interactions between quantum computing and machine learning revolutionize both fields. One prototypical achievement is the quantum auto-encoder (QAE), as the leading strategy to relieve the curse of dimensionality ubiquitous in…

Quantum Physics · Physics 2024-10-03 Yuxuan Du , Dacheng Tao

Variational Quantum Eigensolvers (VQEs) represent a promising approach to computing molecular ground states and energies on modern quantum computers. These approaches use a classical computer to optimize the parameters of a trial wave…

New computational strategies, such as molecular docking, are emerging to speed up the drug discovery process. This method predicts the activity of molecules at the binding site of proteins, helping to select the ones that exhibit desirable…

Quantum Physics · Physics 2024-02-13 Mathieu Garrigues , Victor Onofre , Noé Bosc-Haddad

Quantum embedding is a fundamental prerequisite for applying quantum machine learning techniques to classical data, and has substantial impacts on performance outcomes. In this study, we present Neural Quantum Embedding (NQE), a method that…

Quantum Physics · Physics 2024-08-12 Tak Hur , Israel F. Araujo , Daniel K. Park

This paper introduces a new method that combines Artificial Intelligence (AI) and quantum-inspired techniques to improve the efficiency of multi-variable optimization experiments. By using advanced software simulations, this approach…

We extend the family of problems that may be implemented on an adiabatic quantum optimizer (AQO). When a quadratic optimization problem has at least one set of discrete controls and the constraints are linear, we call this a quadratic…

Quantum Physics · Physics 2014-07-16 Rishabh Chandra , N. Tobias Jacobson , Jonathan E. Moussa , Steven H. Frankel , Sabre Kais

Quantum optimization has emerged as a promising frontier of quantum computing, providing novel numerical approaches to mathematical optimization problems. The main goal of this paper is to facilitate interdisciplinary research between the…

Optimization and Control · Mathematics 2025-09-05 Alexey Bochkarev , Raoul Heese , Sven Jäger , Philine Schiewe , Anita Schöbel

The maximal clique enumeration (MCE) problem has numerous applications in biology, chemistry, sociology, and graph modeling. Though this problem is well studied, most current research focuses on finding solutions in large sparse graphs or…

Data Structures and Algorithms · Computer Science 2018-01-03 Pablo San Segundo , Jorge Artieda , Darren Strash

Network Utility Maximisation (NUM) addresses the problem of allocating resources fairly within a network and explores the ways to achieve optimal allocation in real-world networks. Although extensively studied in classical networks, NUM is…

Networking and Internet Architecture · Computer Science 2024-07-25 Sounak Kar , Stephanie Wehner

We introduce a novel methodology that leverages the strength of Physics-Informed Neural Networks (PINNs) to address the counterdiabatic (CD) protocol in the optimization of quantum circuits comprised of systems with $N_{Q}$ qubits. The…

Optimization-based models have been used to predict cellular behavior for over 25 years. The constraints in these models are derived from genome annotations, measured macro-molecular composition of cells, and by measuring the cell's growth…

Quantitative Methods · Quantitative Biology 2019-05-21 Laurence Yang , Michael A. Saunders , Jean-Christophe Lachance , Bernhard O. Palsson , José Bento

Comparing with traditional learning criteria, such as mean square error (MSE), the minimum error entropy (MEE) criterion is superior in nonlinear and non-Gaussian signal processing and machine learning. The argument of the logarithm in…

Machine Learning · Statistics 2017-10-13 Badong Chen , Lei Xing , Nanning Zheng , Jose C. Príncipe

Genome sequencing is essential to decode genetic information, identify organisms, understand diseases and advance personalized medicine. A critical step in any genome sequencing technique is genome assembly. However, de novo genome…

Background: Beam angle optimization (BAO) is a critical component of radiation therapy (RT) treatment planning, where small changes in beam configuration can significantly impact treatment quality, especially for proton RT. Mathematically,…

Medical Physics · Physics 2025-09-08 Nimita Shinde , Ya-Nan Zhu , Haozheng Shen , Hao Gao

Determining the properties of molecules and materials is one of the premier applications of quantum computing. A major question in the field is how to use imperfect near-term quantum computers to solve problems of practical value. Inspired…

We deal with controlling the spread of an epidemic disease on a network by isolating one or multiple locations by banning people from leaving them. To this aim, we build on the susceptible-infected-susceptible and the…

Systems and Control · Electrical Eng. & Systems 2026-01-14 Lorenzo Zino , Mattia Boggio , Deborah Volpe , Giacomo Orlandi , Giovanna Turvani , Carlo Novara

Efficient entanglement distribution is the foundational challenge in realizing large-scale Quantum Networks. However, state-of-the-art solutions are frequently limited by restrictive operational assumptions, prohibitive computational…