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This paper presents Orthogonal Subspace Clustering (OSC), an innovative method for high-dimensional data clustering. We first establish a theoretical theorem proving that high-dimensional data can be decomposed into orthogonal subspaces in…

Machine Learning · Computer Science 2026-03-17 Qing-Yuan Wen , Da-Qing Zhang

Randomized dimensionality reduction is a widely-used algorithmic technique for speeding up large-scale Euclidean optimization problems. In this paper, we study dimension reduction for a variety of maximization problems, including…

Data Structures and Algorithms · Computer Science 2025-06-03 Jie Gao , Rajesh Jayaram , Benedikt Kolbe , Shay Sapir , Chris Schwiegelshohn , Sandeep Silwal , Erik Waingarten

Sufficient dimension reduction [J. Amer. Statist. Assoc. 86 (1991) 316-342] has long been a prominent issue in multivariate nonparametric regression analysis. To uncover the central dimension reduction space, we propose in this paper an…

Statistics Theory · Mathematics 2014-08-15 Efang Kong , Yingcun Xia

Recent years have seen a surge of novel neural network architectures for the integration of multi-omics data for prediction. Most of the architectures include either encoders alone or encoders and decoders, i.e., autoencoders of various…

Machine Learning · Computer Science 2023-02-15 Tony Hauptmann , Stefan Kramer

Advances in molecular "omics'" technologies have motivated new methodology for the integration of multiple sources of high-content biomedical data. However, most statistical methods for integrating multiple data matrices only consider data…

Machine Learning · Statistics 2020-02-10 Jun Young Park , Eric F. Lock

In this survey, we present and compare different approaches to estimate Mutual Information (MI) from data to analyse general dependencies between variables of interest in a system. We demonstrate the performance difference of MI versus…

Machine Learning · Statistics 2015-06-18 D. Gencaga , N. K. Malakar , D. J. Lary

Given the increasing complexity of omics datasets, a key challenge is not only improving classification performance but also enhancing the transparency and reliability of model decisions. Effective model performance and feature selection…

Machine Learning · Computer Science 2025-05-07 Diego Perazzolo , Pietro Fanton , Ilaria Barison , Marny Fedrigo , Annalisa Angelini , Chiara Castellani , Enrico Grisan

The growing number of dimensionality reduction methods available for data visualization has recently inspired the development of quality assessment measures, in order to evaluate the resulting low-dimensional representation independently…

Machine Learning · Computer Science 2011-10-19 Wouter Lueks , Bassam Mokbel , Michael Biehl , Barbara Hammer

Dimensionality reduction is a common method for analyzing and visualizing high-dimensional data across domains. Dimensionality-reduction algorithms involve complex optimizations and the reduced dimensions computed by these algorithms…

Human-Computer Interaction · Computer Science 2017-08-16 Marco Cavallo , Çağatay Demiralp

The discovery of disease subtypes is an essential step for developing precision medicine, and disease subtyping via omics data has become a popular approach. While promising, subtypes obtained from existing approaches are not necessarily…

Quantitative Methods · Quantitative Biology 2022-03-01 Lingsong Meng , Dorina Avram , George Tseng , Zhiguang Huo

Modern high-throughput sequencing technologies have enabled us to profile multiple molecular modalities from the same single cell, providing unprecedented opportunities to assay celluar heterogeneity from multiple biological layers.…

Machine Learning · Statistics 2022-05-20 Pengcheng Zeng , Zhixiang Lin

Advanced metering infrastructure (AMI) has been widely used as an intelligent energy consumption measurement system. Electric power was the representative energy source that can be collected by AMI; most existing studies to detect abnormal…

Machine Learning · Computer Science 2023-05-05 Taehee Kim , Hyuk-Yoon Kwon

A method for dimension reduction with clustering, classification, or discriminant analysis is introduced. This mixture model-based approach is based on fitting generalized hyperbolic mixtures on a reduced subspace within the paradigm of…

Methodology · Statistics 2017-10-09 Katherine Morris , Paul D. McNicholas

This paper presents a novel theoretical framework for reducing the computational complexity of multi-model adaptive control/estimation systems through systematic transformation to controllable canonical form. While traditional multi-model…

Systems and Control · Electrical Eng. & Systems 2025-04-30 Farid Mafi , Ladan Khoshnevisan , Mohammad Pirani , Amir Khajepour

We explore linear and non-linear dimensionality reduction techniques for statistical inference of parameters in cosmology. Given the importance of compressing the increasingly complex data vectors used in cosmology, we address questions…

Cosmology and Nongalactic Astrophysics · Physics 2025-02-12 Minsu Park , Marco Gatti , Bhuvnesh Jain

Complex dynamical systems are prevalent in various domains, but their analysis and prediction are hindered by their high dimensionality and nonlinearity. Dimensionality reduction techniques can simplify the system dynamics by reducing the…

Dynamical Systems · Mathematics 2023-11-28 Chengyi Tu , Ying Fan , Tianyu Shi

We introduce a dimension reduction method for visualizing the clustering structure obtained from a finite mixture of Gaussian densities. Information on the dimension reduction subspace is obtained from the variation on group means and,…

Methodology · Statistics 2015-08-10 Luca Scrucca

High-confidence prediction of complex traits such as disease risk or drug response is an ultimate goal of personalized medicine. Although genome-wide association studies have discovered thousands of well-replicated polymorphisms associated…

High-dimensional big data appears in many research fields such as image recognition, biology and collaborative filtering. Often, the exploration of such data by classic algorithms is encountered with difficulties due to `curse of…

Machine Learning · Computer Science 2016-07-13 Amit Bermanis , Aviv Rotbart , Moshe Salhov , Amir Averbuch

Data-driven methods play an increasingly important role in discovering geometric, structural, and semantic relationships between 3D shapes in collections, and applying this analysis to support intelligent modeling, editing, and…

Graphics · Computer Science 2015-02-25 Kai Xu , Vladimir G. Kim , Qixing Huang , Evangelos Kalogerakis
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