Related papers: MigraR: an open-source, R-based application for an…
Cell movement, for example during embryogenesis or tumor metastasis, is a complex dynamical process resulting from an intricate interplay of multiple components of the cellular migration machinery. At first sight, the paths of migrating…
Gene expression consists in the synthesis of proteins from the information encoded on DNA. One of the two main steps of gene expression is the translation of messenger RNA (mRNA) into polypeptide sequences of amino acids. Here, by taking…
The menstrual cycle influences numerous physiological and psychological outcomes, yet standardised, open-source statistical methods for quantifying these cyclic effects remain lacking. We developed mcanalysis, an open-source package in R…
For large software systems, refactoring activities can be a challenging task, since for keeping component complexity under control the overall architecture as well as many details of each component have to be considered. Product metrics are…
In the study of complex physical and biological systems represented by multivariate stochastic processes, an issue of great relevance is the description of the system dynamics spanning multiple temporal scales. While methods to assess the…
During migration cells exhibit a rich variety of seemingly random migration patterns, which makes unraveling the underlying mechanisms that control cell migration a daunting challenge. For efficient migration cells require a mechanism for…
The motility of eukaryotic cells is strongly influenced by their environment, with confined cells often developing qualitatively different motility patterns from those migrating on simple two-dimensional substrates. Recent experiments,…
A growing number of visual computing applications depend on the analysis of large video collections. The challenge is that scaling applications to operate on these datasets requires efficient systems for pixel data access and parallel…
User mobility in extended reality (XR) can have a major impact on millimeter-wave (mmWave) links and may require dedicated mitigation strategies to ensure reliable connections and avoid outage. The available prior art has predominantly…
In medicine, reference curves serve as an important tool for everyday clinical practice. Pediatricians assess the growth process of children with the help of percentile curves serving as norm references. The mathematical methods for the…
Data modeling and graphing skill sets are foundational to science learning and careers, yet students regularly struggle to master these basic competencies. Further, although educational researchers have uncovered numerous approaches to…
Cell polarity and movement are fundamental to many biological functions. Experimental and theoretically studies have indicated that interactions of certain proteins lead to the cell polarization which plays a key role in controlling the…
Migrating cells choose their preferential direction of motion in response to different signals and stimuli sensed by spanning their external environment. However, the presence of dense fibrous regions, lack of proper substrate, and cell…
The moveEZ (pronounced move easy) R package provides tools for constructing animated PCA biplots that reveal how multivariate structure evolves across the ordered levels of a categorical variable. Built as an extension to the biplotEZ…
Gait disorders are commonly observed in older adults, who frequently experience various issues related to walking. Additionally, researchers and clinicians extensively investigate mobility related to gait in typically and atypically…
The ability of eukaryotic cells to squeeze through constrictions is limited by the stiffness of their large and rigid nucleus. However, migrating cells are often able to overcome this limitation and pass through constrictions much smaller…
Cell-to-cell variability is inherent to numerous biological processes, including cell migration. Quantifying and characterizing the variability of migrating cells is challenging, as it requires monitoring many cells for long time windows…
In chemotaxis, cells are modulating their migration patterns in response to concentration gradients of a guiding substance. Immune cells are believed to use such chemotactic sensing for remotely detecting and homing in on pathogens.…
Background and Objective: Variables collected over time, or longitudinally, such as biologic measurements in electronic health records data, are not simple to summarize with a single time-point, and thus can be more holistically…
R is a language and environment for statistical computing and graphics, which provides a wide variety of statistical tools (modeling, statistical testing, time series analysis, classification problems, machine learning, ...), together with…