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We develop a stochastic framework for viral population dynamics at the cellular level that explicitly incorporates the replication cycle with random stage durations. The model is formulated as a structured birth-death process coupled with a…

Populations and Evolution · Quantitative Biology 2026-05-13 Seong Jun Park

As Large Language Models (LLMs) continue to exhibit increasingly human-like capabilities, aligning them with human values has become critically important. Contemporary advanced techniques, such as prompt learning and reinforcement learning,…

Computation and Language · Computer Science 2025-06-06 Bangde Du , Ziyi Ye , Zhijing Wu , Jankowska Monika , Shuqi Zhu , Qingyao Ai , Yujia Zhou , Yiqun Liu

A holobiont is made up of a host organism together with its microbiota. In the context of animal breeding, the holobiont can be viewed as the single unit upon which selection operates. Therefore, integrating microbiota data into genomic…

Methodology · Statistics 2026-01-14 Solène Pety , Ingrid David , Andrea Rau , Mahendra Mariadassou

Over the past years, many applications aim to assess the causal effect of treatments assigned at the community level, while data are still collected at the individual level among individuals of the community. In many cases, one wants to…

Applications · Statistics 2020-06-16 Chi Zhang , Jennifer Ahern , Mark J. van der Laan , Oleg Sofrygin

As an alternative to using administrative areas for the evaluation of small-area health inequalities, Sauzet et al. suggested to take an ego-centred approach and model the spatial correlation structure of health outcomes at the individual…

Computation · Statistics 2024-05-14 Julia Dyck , Jan-Ole Koslik , Odile Sauzet

We propose RecSim, a configurable platform for authoring simulation environments for recommender systems (RSs) that naturally supports sequential interaction with users. RecSim allows the creation of new environments that reflect particular…

Machine Learning · Computer Science 2019-09-27 Eugene Ie , Chih-wei Hsu , Martin Mladenov , Vihan Jain , Sanmit Narvekar , Jing Wang , Rui Wu , Craig Boutilier

Knowledge of population distribution is critical for building infrastructure, distributing resources, and monitoring the progress of sustainable development goals. Although censuses can provide this information, they are typically conducted…

Machine Learning · Computer Science 2021-10-07 Isaac Neal , Sohan Seth , Gary Watmough , Mamadou S. Diallo

The concept of "tidy data" offers a powerful framework for structuring data to ease manipulation, modeling and visualization. However, most R functions, both those built-in and those found in third-party packages, produce output that is not…

Computation · Statistics 2014-12-22 David Robinson

Integrating population genetics into community ecology theory is a major goal in ecology and evolution, but analyzing the resulting models is computationally daunting. Here we describe sPEGG ($\underline{\textrm{s}}\textrm{imulating}$…

Quantitative Methods · Quantitative Biology 2016-03-31 Kenichi W. Okamoto , Priyanga Amarasekare

A representation of heterogeneous stochastic populations that are composed of sub-populations with different levels of distinguishability is introduced together with an analysis of its properties. It is demonstrated that any instance of…

Probability · Mathematics 2019-12-02 Jeremie Houssineau , Daniel E. Clark

Our purpose is to estimate the posterior distribution of the parameters of interest for controlled branching processes (CBPs) without prior knowledge of the maximum number of offspring that an individual can give birth to and without…

Methodology · Statistics 2021-08-10 Miguel González , Carmen Minuesa , Inés del Puerto

Large networks of queueing systems model important real-world systems such as MapReduce clusters, web-servers, hospitals, call centers and airport passenger terminals. To model such systems accurately, we must infer queueing parameters from…

Computation · Statistics 2021-04-20 Anthony Ebert , Paul Wu , Kerrie Mengersen , Fabrizio Ruggeri

Reaction diffusion equations have been used to model a wide range of biological phenomenon related to population spread and proliferation from ecology to cancer. It is commonly assumed that individuals in a population have homogeneous…

Dynamical Systems · Mathematics 2023-04-14 Kyle Nguyen , Erica M. Rutter , Kevin Flores

The dynamics of contact networks and epidemics of infectious diseases often occur on comparable time scales. Ignoring one of these time scales may provide an incomplete understanding of the population dynamics of the infection process. We…

Populations and Evolution · Quantitative Biology 2021-02-09 Luis E C Rocha , Naoki Masuda

Tissues are often heterogeneous in their single-cell molecular expression, and this can govern the regulation of cell fate. For the understanding of development and disease, it is important to quantify heterogeneity in a given tissue. We…

Applications · Statistics 2020-04-21 Lisa Amrhein , Christiane Fuchs

This letter introduced a new R package 'coexist' which can perform species coexistence simulation and analysis. The package was initially developed for understanding the role of different combinations of varying species growth rates,…

Populations and Evolution · Quantitative Biology 2014-04-11 Youhua Chen

This exposition presents nimblewomble, a software package to perform wombling, or boundary analysis, using the nimble Bayesian hierarchical modeling language in the R statistical computing environment. Wombling is used widely to track…

Computation · Statistics 2025-04-11 Aritra Halder , Sudipto Banerjee

Personalized models are essential in digital health because individuals exhibit substantial physiological and behavioral heterogeneity. Yet personalization is limited by scarce and noisy user-specific data. Most existing methods rely on…

Artificial Intelligence · Computer Science 2026-05-15 Zhongqi Yang , Mahkameh Rasouli , Neda Mohseni , Yong Huang , Iman Azimi , Amir M. Rahmani

Systems that rely on forecasts to make decisions, e.g. control or energy trading systems, require frequent updates of the forecasts. Usually, the forecasts are updated whenever new observations become available, hence in an online setting.…

This article introduces GuessCompx which is an R package that performs an empirical estimation on the time and memory complexities of an algorithm or a function. It tests multiple increasing-sizes samples of the user's data and attempts to…

Data Structures and Algorithms · Computer Science 2020-10-22 Marc Agenis-Nevers , Neeraj Dhanraj Bokde , Zaher Mundher Yaseen , Mayur Shende