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We introduce HyperMorph, a framework that facilitates efficient hyperparameter tuning in learning-based deformable image registration. Classical registration algorithms perform an iterative pair-wise optimization to compute a deformation…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Andrew Hoopes , Malte Hoffmann , Douglas N. Greve , Bruce Fischl , John Guttag , Adrian V. Dalca

Registration is a fundamental task in medical robotics and is often a crucial step for many downstream tasks such as motion analysis, intra-operative tracking and image segmentation. Popular registration methods such as ANTs and NiftyReg…

Computer Vision and Pattern Recognition · Computer Science 2021-03-26 Wentao Zhu , Yufang Huang , Daguang Xu , Zhen Qian , Wei Fan , Xiaohui Xie

The successful training of deep neural networks requires addressing challenges such as overfitting, numerical instabilities leading to divergence, and increasing variance in the residual stream. A common solution is to apply regularization…

Machine Learning · Computer Science 2025-11-20 Jörg K. H. Franke , Urs Spiegelhalter , Marianna Nezhurina , Jenia Jitsev , Frank Hutter , Michael Hefenbrock

We propose a registration algorithm for 2D CT/MRI medical images with a new unsupervised end-to-end strategy using convolutional neural networks. The contributions of our algorithm are threefold: (1) We transplant traditional image…

Computer Vision and Pattern Recognition · Computer Science 2018-01-23 Siyuan Shan , Wen Yan , Xiaoqing Guo , Eric I-Chao Chang , Yubo Fan , Yan Xu

In clinical practice, well-aligned multi-modal images, such as Magnetic Resonance (MR) and Computed Tomography (CT), together can provide complementary information for image-guided therapies. Multi-modal image registration is essential for…

Computer Vision and Pattern Recognition · Computer Science 2022-04-29 Zekang Chen , Jia Wei , Rui Li

Recent developments in deep learning have revolutionized the paradigm of image restoration. However, its applications on real image denoising are still limited, due to its sensitivity to training data and the complex nature of real image…

Computer Vision and Pattern Recognition · Computer Science 2019-05-06 Jin Zeng , Jiahao Pang , Wenxiu Sun , Gene Cheung

Deep convolutional neural networks for semantic segmentation achieve outstanding accuracy, however they also have a couple of major drawbacks: first, they do not generalize well to distributions slightly different from the one of the…

Computer Vision and Pattern Recognition · Computer Science 2021-07-08 Francesco Barbato , Marco Toldo , Umberto Michieli , Pietro Zanuttigh

Recent advances in deep learning-based medical image registration have shown that training deep neural networks~(DNNs) does not necessarily require medical images. Previous work showed that DNNs trained on randomly generated images with…

Computer Vision and Pattern Recognition · Computer Science 2025-06-02 Junyu Chen , Shuwen Wei , Yihao Liu , Aaron Carass , Yong Du

We propose a regularization scheme for image reconstruction that leverages the power of deep learning while hinging on classic sparsity-promoting models. Many deep-learning-based models are hard to interpret and cumbersome to analyze…

Image and Video Processing · Electrical Eng. & Systems 2024-07-10 Mehrsa Pourya , Sebastian Neumayer , Michael Unser

Deformable image registration between Computed Tomography (CT) images and Magnetic Resonance (MR) imaging is essential for many image-guided therapies. In this paper, we propose a novel translation-based unsupervised deformable image…

Image and Video Processing · Electrical Eng. & Systems 2020-09-22 Zhe Xu , Jie Luo , Jiangpeng Yan , Ritvik Pulya , Xiu Li , William Wells , Jayender Jagadeesan

Self-supervised learning has shown great potentials in improving the deep learning model in an unsupervised manner by constructing surrogate supervision signals directly from the unlabeled data. Different from existing works, we present a…

Computer Vision and Pattern Recognition · Computer Science 2020-08-06 Jinpeng Wang , Yiqi Lin , Andy J. Ma

In this paper we propose a new approach for tomographic reconstruction with spatially varying regularization parameter. Our work is based on the SA-TV image restoration model proposed in [3] where an automated parameter selection rule for…

Numerical Analysis · Mathematics 2018-11-27 Yiqiu Dong , Carola-Bibiane Schönlieb

Diffeomorphic image registration, offering smooth transformation and topology preservation, is required in many medical image analysis tasks.Traditional methods impose certain modeling constraints on the space of admissible transformations…

Computer Vision and Pattern Recognition · Computer Science 2022-11-03 Kun Han , Shanlin sun , Xiangyi Yan , Chenyu You , Hao Tang , Junayed Naushad , Haoyu Ma , Deying Kong , Xiaohui Xie

State-of-the-art learned reconstruction methods often rely on black-box modules that, despite their strong performance, raise questions about their interpretability and robustness. Here, we build on a recently proposed image reconstruction…

Image and Video Processing · Electrical Eng. & Systems 2026-05-19 Joshua Schulz , David Schote , Christoph Kolbitsch , Kostas Papafitsoros , Andreas Kofler

In this study, the problem of computing a sparse representation of multi-dimensional visual data is considered. In general, such data e.g., hyperspectral images, color images or video data consists of signals that exhibit strong local…

Computer Vision and Pattern Recognition · Computer Science 2023-03-16 Alexandros Gkillas , Dimitris Ampeliotis , Kostas Berberidis

Regularization is essential in deformable image registration (DIR) to ensure that the estimated Deformation Vector Field (DVF) remains smooth, physically plausible, and anatomically consistent. However, fine-tuning regularization parameters…

Computer Vision and Pattern Recognition · Computer Science 2025-07-18 Sidaty El Hadramy , Oumeymah Cherkaoui , Philippe C. Cattin

We introduce a novel stochastic regularization technique for deep neural networks, which decomposes a layer into multiple branches with different parameters and merges stochastically sampled combinations of the outputs from the branches…

Machine Learning · Computer Science 2019-10-04 Wonpyo Park , Paul Hongsuck Seo , Bohyung Han , Minsu Cho

Recently, cross domain transfer has been applied for unsupervised image restoration tasks. However, directly applying existing frameworks would lead to domain-shift problems in translated images due to lack of effective supervision.…

Computer Vision and Pattern Recognition · Computer Science 2020-03-31 Wenchao Du , Hu Chen , Hongyu Yang

Deformable image registration is a fundamental task in medical image analysis, aiming to establish a dense and non-linear correspondence between a pair of images. Previous deep-learning studies usually employ supervised neural networks to…

Computer Vision and Pattern Recognition · Computer Science 2018-09-11 Jun Zhang

We describe an adversarial learning approach to constrain convolutional neural network training for image registration, replacing heuristic smoothness measures of displacement fields often used in these tasks. Using minimally-invasive…

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