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Histopathology image analysis plays a crucial role in cancer diagnosis. However, training a clinically applicable segmentation algorithm requires pathologists to engage in labour-intensive labelling. In contrast, weakly supervised learning…

Computer Vision and Pattern Recognition · Computer Science 2024-05-28 Gang Xu , Shuhao Wang , Lingyu Zhao , Xiao Chen , Tongwei Wang , Lang Wang , Zhenwei Luo , Dahan Wang , Zewen Zhang , Aijun Liu , Wei Ba , Zhigang Song , Huaiyin Shi , Dingrong Zhong , Jianpeng Ma

Accurate and robust cell nuclei classification is the cornerstone for a wider range of tasks in digital and Computational Pathology. However, most machine learning systems require extensive labeling from expert pathologists for each…

Quantitative Methods · Quantitative Biology 2016-12-05 Stefan Bauer , Nicolas Carion , Peter Schüffler , Thomas Fuchs , Peter Wild , Joachim M. Buhmann

This work contributes to breast cancer sub-type classification using histopathological images. We utilize masked autoencoders (MAEs) to learn a self-supervised embedding tailored for computer vision tasks in this domain. This embedding…

Computer Vision and Pattern Recognition · Computer Science 2025-06-10 Annalisa Chiocchetti , Marco Dossena , Christopher Irwin , Luigi Portinale

Histopathology Whole-Slide Images (WSIs) provide an important tool to assess cancer prognosis in computational pathology (CPATH). While existing survival analysis (SA) approaches have made exciting progress, they are generally limited to…

Computer Vision and Pattern Recognition · Computer Science 2025-02-12 Pei Liu , Luping Ji , Jiaxiang Gou , Bo Fu , Mao Ye

Forensic pathology is critical in analyzing death manner and time from the microscopic aspect to assist in the establishment of reliable factual bases for criminal investigation. In practice, even the manual differentiation between…

Computer Vision and Pattern Recognition · Computer Science 2023-08-29 Chen Shen , Jun Zhang , Xinggong Liang , Zeyi Hao , Kehan Li , Fan Wang , Zhenyuan Wang , Chunfeng Lian

Breast cancer cell lines are indispensable tools for unraveling disease mechanisms, enabling drug discovery, and developing personalized treatments, yet their heterogeneity and inconsistent classification pose significant challenges in…

In histopathological image analysis, feature extraction for classification is a challenging task due to the diversity of histology features suitable for each problem as well as presence of rich geometrical structure. In this paper, we…

Computer Vision and Pattern Recognition · Computer Science 2016-11-18 Tiep H. Vu , Hojjat S. Mousavi , Vishal Monga , UK Arvind Rao , Ganesh Rao

Since real-world machine systems are running in non-stationary environments, Continual Test-Time Adaptation (CTTA) task is proposed to adapt the pre-trained model to continually changing target domains. Recently, existing methods mainly…

Computer Vision and Pattern Recognition · Computer Science 2024-03-28 Jiaming Liu , Senqiao Yang , Peidong Jia , Renrui Zhang , Ming Lu , Yandong Guo , Wei Xue , Shanghang Zhang

Histological subtype of papillary (p) renal cell carcinoma (RCC), type 1 vs. type 2, is an essential prognostic factor. The two subtypes of pRCC have a similar pattern, i.e., the papillary architecture, yet some subtle differences,…

Computer Vision and Pattern Recognition · Computer Science 2021-06-24 Zeyu Gao , Bangyang Hong , Xianli Zhang , Yang Li , Chang Jia , Jialun Wu , Chunbao Wang , Deyu Meng , Chen Li

Computational pathology (CoPath) leverages histopathology images to enhance diagnostic precision and reproducibility in clinical pathology. However, publicly available datasets for CoPath that are annotated with extensive histological…

Digitization of histopathology slides has led to several advances, from easy data sharing and collaborations to the development of digital diagnostic tools. Deep learning (DL) methods for classification and detection have shown great…

Image and Video Processing · Electrical Eng. & Systems 2020-05-25 Apostolia Tsirikoglou , Karin Stacke , Gabriel Eilertsen , Martin Lindvall , Jonas Unger

Convolutional neural networks (CNNs) have been recently used for a variety of histology image analysis. However, availability of a large dataset is a major prerequisite for training a CNN which limits its use by the computational pathology…

Computer Vision and Pattern Recognition · Computer Science 2018-03-07 Ruqayya Awan , Navid Alemi Koohbanani , Muhammad Shaban , Anna Lisowska , Nasir Rajpoot

Supervised learning method requires a large volume of annotated datasets. Collecting such datasets is time-consuming and expensive. Until now, very few annotated COVID-19 imaging datasets are available. Although self-supervised learning…

Image and Video Processing · Electrical Eng. & Systems 2020-12-14 Li Sun , Ke Yu , Kayhan Batmanghelich

Recently, deep neural networks have greatly advanced histopathology image segmentation but usually require abundant annotated data. However, due to the gigapixel scale of whole slide images and pathologists' heavy daily workload, obtaining…

Computer Vision and Pattern Recognition · Computer Science 2023-03-13 Wentao Pan , Jiangpeng Yan , Hanbo Chen , Jiawei Yang , Zhe Xu , Xiu Li , Jianhua Yao

Artificial intelligence has made significant strides in medical visual question answering (Med-VQA), yet prevalent studies often interpret images holistically, overlooking the visual regions of interest that may contain crucial information,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Xupeng Chen , Zhixin Lai , Kangrui Ruan , Shichu Chen , Jiaxiang Liu , Zuozhu Liu

Histopathology images are gigapixel-sized and include features and information at different resolutions. Collecting annotations in histopathology requires highly specialized pathologists, making it expensive and time-consuming.…

Computer Vision and Pattern Recognition · Computer Science 2022-11-16 Jin Li , Deepta Rajan , Chintan Shah , Dinkar Juyal , Shreya Chakraborty , Chandan Akiti , Filip Kos , Janani Iyer , Anand Sampat , Ali Behrooz

Cell detection, segmentation and classification are essential for analyzing tumor microenvironments (TME) on hematoxylin and eosin (H&E) slides. Existing methods suffer from poor performance on understudied cell types (rare or not present…

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

Quantitative Methods · Quantitative Biology 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He

Multimodal pathology-genomic analysis has become increasingly prominent in cancer survival prediction. However, existing studies mainly utilize multi-instance learning to aggregate patch-level features, neglecting the information loss of…

Computer Vision and Pattern Recognition · Computer Science 2025-05-21 Mingcheng Qu , Guang Yang , Donglin Di , Tonghua Su , Yue Gao , Yang Song , Lei Fan

For personalized medicines, very crucial intrinsic information is present in high dimensional omics data which is difficult to capture due to the large number of molecular features and small number of available samples. Different types of…

Machine Learning · Computer Science 2022-02-04 Sayed Hashim , Muhammad Ali , Karthik Nandakumar , Mohammad Yaqub